A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression
The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 27, 2018 Category: Research Authors: Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti Jr, Christopher B. Mobley, Charlotte A. Peterson and John J. McCarthy Tags: Methodology Source Type: research
Myostatin and activin blockade by engineered follistatin results in hypertrophy and improves dystrophic pathology in mdx mouse more than myostatin blockade alone
Myostatin antagonists are being developed as therapies for Duchenne muscular dystrophy due to their strong hypertrophic effects on skeletal muscle. Engineered follistatin has the potential to combine the hyper... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 27, 2018 Category: Research Authors: Andrea Iskenderian, Nan Liu, Qingwei Deng, Yan Huang, Chuan Shen, Kathleen Palmieri, Robert Crooker, Dianna Lundberg, Niksa Kastrapeli, Brian Pescatore, Alla Romashko, John Dumas, Robert Comeau, Angela Norton, Jing Pan, Haojing Rong & hellip; Tags: Research Source Type: research
Automated muscle histopathology analysis using CellProfiler
Histological assessment of skeletal muscle sections is important for the research of muscle physiology and diseases. Quantifiable measures of skeletal muscle often include mean fiber diameter, fiber size distr... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 18, 2018 Category: Research Authors: Yeh Siang Lau, Li Xu, Yandi Gao and Renzhi Han Tags: Software Source Type: research
Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers
The scientific premise, design, and structure-function analysis of chemical-based muscle membrane stabilizing block copolymers are reviewed here for applications in striated muscle membrane injury. Synthetic b... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 10, 2018 Category: Research Authors: Evelyne M. Houang, Yuk Y. Sham, Frank S. Bates and Joseph M. Metzger Tags: Review Source Type: research
Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction
The skeletal muscle fiber has a specific and precise intracellular organization which is at the basis of an efficient muscle contraction. Microtubules are long known to play a major role in the function and or... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 19, 2018 Category: Research Authors: Muriel S ébastien, Benoit Giannesini, Perrine Aubin, Julie Brocard, Mathilde Chivet, Laura Pietrangelo, Simona Boncompagni, Christophe Bosc, Jacques Brocard, John Rendu, Sylvie Gory-Fauré, Annie Andrieux, Anne Fourest-Lieuvin, Julien Fauré and Isabelle Tags: Research Source Type: research
The effects of neuregulin-1 β on intrafusal muscle fiber formation in neuromuscular coculture of dorsal root ganglion explants and skeletal muscle cells
The formation of intrafusal muscle (IM) fibers and their contact with afferent proprioceptive axons is critical for construction, function, and maintenance of the stretch reflex. Many factors affect the format... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 15, 2018 Category: Research Authors: Yuan Qiao, Menglin Cong, Jianmin Li, Hao Li and Zhenzhong Li Tags: Research Source Type: research
Biochemical and pathological changes result from mutated Caveolin-3 in muscle
Caveolin-3 (CAV3) is a muscle-specific protein localized to the sarcolemma. It was suggested that CAV3 is involved in the connection between the extracellular matrix (ECM) and the cytoskeleton. Caveolinopathie... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 28, 2018 Category: Research Authors: Jos é Andrés González Coraspe, Joachim Weis, Mary E. Anderson, Ute Münchberg, Kristina Lorenz, Stephan Buchkremer, Stephanie Carr, René Peiman Zahedi, Eva Brauers, Hannah Michels, Yoshihide Sunada, Hanns Lochmüller, Kevin P. Campbell, Erik Freier, D Tags: Research Source Type: research
Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line
Satellite cells are residential muscle stem cells that express a paired box protein, PAX7. (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 24, 2018 Category: Research Authors: Yasuo Kitajima and Yusuke Ono Tags: Methodology Source Type: research
A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells
Pax7 is a transcription factor involved in the specification and maintenance of muscle stem cells (MuSCs). Upon injury, MuSCs leave their quiescent state, downregulate Pax7 and differentiate, contributing to s... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 24, 2018 Category: Research Authors: Elisia D. Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau and Foteini Mourkioti Tags: Research Source Type: research
MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool
Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immun... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 6, 2018 Category: Research Authors: Alicia Mayeuf-Louchart, David Hardy, Quentin Thorel, Pascal Roux, Lorna Gueniot, David Briand, Aur élien Mazeraud, Adrien Bouglé, Spencer L. Shorte, Bart Staels, Fabrice Chrétien, Hélène Duez and Anne Danckaert Tags: Methodology Source Type: research
Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage
SMCHD1 is a disease modifier and a causative gene for facioscapulohumeral muscular dystrophy (FSHD) type 1 and type 2, respectively. A large variety of different mutations in SMCHD1 have been identified as cau... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 2, 2018 Category: Research Authors: Yosuke Hiramuki and Stephen J. Tapscott Tags: Research Source Type: research
Detection of variants in dystroglycanopathy-associated genes through the application of targeted whole-exome sequencing analysis to a large cohort of patients with unexplained limb-girdle muscle weakness
Dystroglycanopathies are a clinically and genetically heterogeneous group of disorders that are typically characterised by limb-girdle muscle weakness. Mutations in 18 different genes have been associated with... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 30, 2018 Category: Research Authors: Katherine Johnson, Marta Bertoli, Lauren Phillips, Ana T öpf, Peter Van den Bergh, John Vissing, Nanna Witting, Shahriar Nafissi, Shirin Jamal-Omidi, Anna Łusakowska, Anna Kostera-Pruszczyk, Anna Potulska-Chromik, Nicolas Deconinck, Carina Wallgren-Pett Tags: Research Source Type: research
Whole-body clearing, staining and screening of calcium deposits in the mdx mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a fatal, X-linked genetic disorder. Although DMD is the most common form of muscular dystrophy, only two FDA-approved drugs were developed to delay its progression. In orde... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 19, 2018 Category: Research Authors: Lukasz Bozycki, Kacper Łukasiewicz, Paweł Matryba and Slawomir Pikula Tags: Methodology Source Type: research
Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?
The process by which muscle fiber electrical depolarization is linked to activation of muscle contraction is known as excitation-contraction coupling (ECC). Our understanding of ECC has increased enormously si... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 19, 2018 Category: Research Authors: Erick O. Hern ández-Ochoa and Martin F. Schneider Tags: Review Source Type: research
Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 4, 2018 Category: Research Authors: Hellen E. Ahrens, Judith Huettemeister, Manuel Schmidt, Christoph Kaether and Julia von Maltzahn Tags: Research Source Type: research
