Fragile X mental retardation protein regulates skeletal muscle stem cell activity by regulating the stability of Myf5 mRNA
Regeneration of adult tissues relies on adult stem cells that are primed to enter a differentiation program, while typically remaining quiescent. In mouse skeletal muscle, these features are reconciled by mult... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 7, 2017 Category: Research Authors: Ryo Fujita, Victoria Zismanov, Jean-Marie Jacob, Sol ène Jamet, Krum Asiev and Colin Crist Tags: Research Source Type: research
Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass
In contrast to the acute effects of growth hormone (GH) on skeletal muscle protein synthesis, long-term GH treatment appears to have negligible effects on muscle mass. Despite this knowledge, little is known r... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 4, 2017 Category: Research Authors: Leslie A. Consitt, Alicson Saneda, Gunjan Saxena, Edward O. List and John J. Kopchick Tags: Research Source Type: research
BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells
Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscl... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 4, 2017 Category: Research Authors: Amy E. Campbell, Jonathan Oliva, Matthew P. Yates, Jun Wen Zhong, Sean C. Shadle, Lauren Snider, Nikita Singh, Shannon Tai, Yosuke Hiramuki, Rabi Tawil, Silv ère M. van der Maarel, Stephen J. Tapscott and Francis M. Sverdrup Tags: Research Source Type: research
Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers
Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of inherited autosomal myopathies that preferentially affect voluntary muscles of the shoulders and hips. LGMD has been clinically described i... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 11, 2017 Category: Research Authors: Melissa L. Cox, Jacquelyn M. Evans, Alexander G. Davis, Ling T. Guo, Jennifer R. Levy, Alison N. Starr-Moss, Elina Salmela, Marjo K. Hyt önen, Hannes Lohi, Kevin P. Campbell, Leigh Anne Clark and G. Diane Shelton Source Type: research
Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice
Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the i... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 10, 2017 Category: Research Authors: Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy and Charlotte A. Peterson Source Type: research
Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures
Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 21, 2017 Category: Research Authors: Premi Haynes, Kelly Kernan, Suk-Lin Zhou and Daniel G. Miller Source Type: research
Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F
Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 6, 2017 Category: Research Authors: Angela K. Peter, Gaynor Miller, Joana Capote, Marino DiFranco, Alhondra Solares-P érez, Emily L. Wang, Jim Heighway, Ramón M. Coral-Vázquez, Julio Vergara and Rachelle H. Crosbie-Watson Source Type: research
SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes
Facioscapulohumeral muscular dystrophy (FSHD) is in most cases caused by a contraction of the D4Z4 macrosatellite repeat on chromosome 4 (FSHD1) or by mutations in the SMCHD1 or DNMT3B gene (FSHD2). Both situatio... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 6, 2017 Category: Research Authors: Amanda G. Mason, Roderick C. Slieker, Judit Balog, Richard J. L. F. Lemmers, Chao-Jen Wong, Zizhen Yao, Jong-Won Lim, Galina N. Filippova, Enrico Ne, Rabi Tawil, Bas T. Heijmans, Stephen J. Tapscott and Silv ère M. van der Maarel Source Type: research
Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through it... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 1, 2017 Category: Research Authors: Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff and Peter G. Noakes Source Type: research
The golden retriever model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin. The absence of dystrophin leads to myofiber membrane fragility and necrosis, with e... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 19, 2017 Category: Research Authors: Joe N. Kornegay Source Type: research
Unexpected evolutionarily conserved rapid effects of viral infection on oxytocin receptor and TGF- β/pSmad3
shRNA lentiviral vectors are extensively used for gene knockdowns in mammalian cells, and non-target shRNAs typically are considered the proper experimental control for general changes caused by RNAi. However,... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 15, 2017 Category: Research Authors: Yutong Liu and Irina Conboy Source Type: research
Retinoid acid-induced microRNA-31-5p suppresses myogenic proliferation and differentiation by targeting CamkII δ
We previously reported that Wnt5a/CaMKII δ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study fo... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 11, 2017 Category: Research Authors: Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang and Jing Xiao Source Type: research
Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation
Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known t... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 10, 2017 Category: Research Authors: Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma and Jingsong Zhou Source Type: research
Linkages between changes in the 3D organization of the genome and transcription during myotube differentiation in vitro
The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 5, 2017 Category: Research Authors: Malina D. Doynova, James F. Markworth, David Cameron-Smith, Mark H. Vickers and Justin M. O ’Sullivan Source Type: research
