Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators
Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the effica... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 1, 2020 Category: Research Authors: Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti and Dawn A. Lowe Tags: Research Source Type: research
Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function
Nebulin is a critical thin filament-binding protein that spans from the Z-disk of the skeletal muscle sarcomere to near the pointed end of the thin filament. Its massive size and actin-binding property allows ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 28, 2020 Category: Research Authors: Frank Li, Justin Kolb, Julie Crudele, Zaynab Hourani, John E. Smith III, Jeffrey S. Chamberlain and Henk Granzier Tags: Research Source Type: research
The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvatio... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 16, 2020 Category: Research Authors: Clayton Whitmore, Evan P.S. Pratt, Luke Anderson, Kevin Bradley, Sawyer M. Latour, Mariam N. Hashmi, Albert K. Urazaev, Rod Weilbaecher, Judith K. Davie, Wen-Horng Wang, Gregory H. Hockerman and Amber L. Pond Tags: Research Source Type: research
Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by loss of sarcolemma connection to the extracellular matrix. Transgenic overexpression of the transmembrane protein sarcospan (SSPN) in the DMD mdx mouse model signifi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 12, 2019 Category: Research Authors: Cynthia Shu, Ariana N. Kaxon-Rupp, Judd R. Collado, Robert Damoiseaux and Rachelle H. Crosbie Tags: Research Source Type: research
miR-1/206 downregulates splicing factor Srsf9 to promote C2C12 differentiation
Myogenesis is driven by specific changes in the transcriptome that occur during the different stages of muscle differentiation. In addition to controlled transcriptional transitions, several other post-transcr... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 2, 2019 Category: Research Authors: Kristen K. Bjorkman, Massimo Buvoli, Emily K. Pugach, Michael M. Polmear and Leslie A. Leinwand Tags: Research Source Type: research
mTORC2 affects the maintenance of the muscle stem cell pool
The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, P... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 2, 2019 Category: Research Authors: Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard and Markus A. R üegg Tags: Research Source Type: research
In memoriam: Susan Abmayr (1956 –2019) – “What do we do? Whatever it takes!”
(Source: Skeletal Muscle)
Source: Skeletal Muscle - November 27, 2019 Category: Research Authors: Erika R. Geisbrecht and Mary K. Baylies Tags: Obituary Source Type: research
Two functional variants at 6p21.1 were associated with lean mass
Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genetic factors underlying lean mass development. (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 23, 2019 Category: Research Authors: Yu-Fang Pei, Wen-Zhu Hu, Xiao-Lin Yang, Xin-Tong Wei, Gui-Juan Feng, Hong Zhang, Hui Shen, Qing Tian, Hong-Wen Deng and Lei Zhang Tags: Research Source Type: research
Barium chloride injures myofibers through calcium-induced proteolysis with fragmentation of motor nerves and microvessels
Local injection of BaCl2 is an established model of acute injury to study the regeneration of skeletal muscle. However, the mechanism by which BaCl2 causes muscle injury is unresolved. Because Ba2+ inhibits K+ ch... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 6, 2019 Category: Research Authors: Aaron B. Morton, Charles E. Norton, Nicole L. Jacobsen, Charmain A. Fernando, D. D. W. Cornelison and Steven S. Segal Tags: Research Source Type: research
LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force
Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 31, 2019 Category: Research Authors: Duarte M. S. Ferreira, Arthur J. Cheng, Leandro Z. Agudelo, Igor Cervenka, Thomas Chaillou, Jorge C. Correia, Margareta Porsmyr-Palmertz, Manizheh Izadi, Alicia Hansson, Vicente Mart ínez-Redondo, Paula Valente-Silva, Amanda T. Pettersson-Klein, Jennifer Tags: Research Source Type: research
Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration
During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 18, 2019 Category: Research Authors: David Hardy, Myl ène Fefeu, Aurore Besnard, David Briand, Paméla Gasse, Fernando Arenzana-Seisdedos, Pierre Rocheteau and Fabrice Chrétien Tags: Research Source Type: research
Immunohistochemical phenotyping of T cells, granulocytes, and phagocytes in the muscle of cancer patients: association with radiologically defined muscle mass and gene expression
Inflammation is a recognized contributor to muscle wasting. Research in injury and myopathy suggests that interactions between the skeletal muscle and immune cells confer a pro-inflammatory environment that in... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 14, 2019 Category: Research Authors: Ana Anoveros-Barrera, Amritpal S. Bhullar, Cynthia Stretch, Abha R. Dunichand-Hoedl, Karen J. B. Martins, Aja Rieger, David Bigam, Todd McMullen, Oliver F. Bathe, Charles T. Putman, Catherine J. Field, Vickie E. Baracos and Vera C. Mazurak Tags: Research Source Type: research
Ibuprofen inhibited migration of skeletal muscle cells in association with downregulation of p130cas and CrkII expressions
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat sports-related muscle injuries. However, NSAIDs were recently shown to impede the muscle healing process after acute injury. Migration o... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 29, 2019 Category: Research Authors: Chih-Hao Liao, Li-Ping Lin, Tung-Yang Yu, Chih-Chin Hsu, Jong-Hwei S. Pang and Wen-Chung Tsai Tags: Research Source Type: research
miR-146a deficiency does not aggravate muscular dystrophy in mdx mice
Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation. Up to this date, mainly ant... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 14, 2019 Category: Research Authors: Iwona Bronisz-Budzy ńska, Katarzyna Chwalenia, Olga Mucha, Paulina Podkalicka, Karolina-Bukowska-Strakova, Alicja Józkowicz, Agnieszka Łoboda, Magdalena Kozakowska and Józef Dulak Tags: Research Source Type: research
NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy
Secondary dystroglycanopathies are muscular dystrophies that result from mutations in genes that participate in Dystroglycan glycosylation. Glycosylation of Dystroglycan is essential for muscle fibers to adher... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 7, 2019 Category: Research Authors: Erin C. Bailey, Sarah S. Alrowaished, Elisabeth A. Kilroy, Emma S. Crooks, Daisy M. Drinkert, Chaya M. Karunasiri, Joseph J. Belanger, Andre Khalil, Joshua B. Kelley and Clarissa A. Henry Tags: Research Source Type: research
