Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells
Estrogen signaling is indispensable for muscle regeneration, yet the role of estrogen in the development of muscle inflammation, especially in the intramuscular T cell response, and the influence on the intrin... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 29, 2019 Category: Research Authors: Zhao Hong Liao, Tao Huang, Jiang Wei Xiao, Rui Cai Gu, Jun Ouyang, Gang Wu and Hua Liao Tags: Research Source Type: research
Regulation of murine skeletal muscle growth by STAT5B is age- and sex-specific
Sexually dimorphic growth has been attributed to the growth hormone (GH)/insulin-like growth factor 1 (IGF1) axis, particularly GH-induced activation of the intracellular signal transducer and activator of tra... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 24, 2019 Category: Research Authors: Ryan G. Paul, Alex S. Hennebry, Marianne S. Elston, John V. Conaglen and Chris D. McMahon Tags: Research Source Type: research
Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells
Trauma-induced heterotopic ossification (HO) is a complication that develops under three conditions: the presence of an osteogenic progenitor cell, an inducing factor, and a permissive environment. We previous... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 19, 2019 Category: Research Authors: Genevi ève Drouin, Vanessa Couture, Marc-Antoine Lauzon, Frédéric Balg, Nathalie Faucheux and Guillaume Grenier Tags: Research Source Type: research
Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation
Skeletal muscle contributes to roughly 40% of lean body mass, and its loss contributes to morbidity and mortality in a variety of pathogenic conditions. Significant insights into muscle function have been made... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 7, 2019 Category: Research Authors: Lance T. Denes, Lance A. Riley, Joseph R. Mijares, Juan D. Arboleda, Kendra McKee, Karyn A. Esser and Eric T. Wang Tags: Research Source Type: research
Congenital myopathy with hanging big toe due to homozygous myopalladin (MYPN) mutation
Myopalladin (MYPN) is a component of the sarcomere that tethers nebulin in skeletal muscle and nebulette in cardiac muscle to alpha-actinin at the Z lines. Autosomal dominant MYPN mutations cause hypertrophic, di... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 27, 2019 Category: Research Authors: Luciano Merlini, Patrizia Sabatelli, Manuela Antoniel, Valeria Carinci, Fabio Niro, Giuseppe Monetti, Annalaura Torella, Teresa Giugliano, Cesare Faldini and Vincenzo Nigro Tags: Case Report Source Type: research
Automated image-analysis method for the quantification of fiber morphometry and fiber type population in human skeletal muscle
The quantitative analysis of muscle histomorphometry has been growing in importance in both research and clinical settings. Accurate and stringent assessment of myofibers ’ changes in size and number, and alter... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 27, 2019 Category: Research Authors: Perla C. Reyes-Fernandez, Baptiste Periou, Xavier Decrouy, Fr éderic Relaix and François Jérôme Authier Tags: Research Source Type: research
A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor β superfamily. The GDF11 propeptide, which is derived from the GDF11 precursor protein, blocks the activity of GDF11 and i... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 27, 2019 Category: Research Authors: Quan Jin, Chunping Qiao, Jianbin Li, Bin Xiao, Juan Li and Xiao Xiao Tags: Research Source Type: research
Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy
Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fibe... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 24, 2019 Category: Research Authors: Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse and Robert G. Korneluk Tags: Research Source Type: research
Preclinical rationale for entinostat in embryonal rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years. We previously identified t... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 21, 2019 Category: Research Authors: Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Manc Tags: Research Source Type: research
Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma
α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 4, 2019 Category: Research Authors: Daniel Beltr án, Mary E. Anderson, Narendra Bharathy, Teagan P. Settelmeyer, Matthew N. Svalina, Zia Bajwa, John F. Shern, Sakir H. Gultekin, Marco A. Cuellar, Takahiro Yonekawa, Charles Keller and Kevin P. Campbell Tags: Research Source Type: research
Muscle Gene Sets: a versatile methodological aid to functional genomics in the neuromuscular field
The approach of building large collections of gene sets and then systematically testing hypotheses across these collections is a powerful tool in functional genomics, both in the pathway analysis of omics data... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 3, 2019 Category: Research Authors: Apostolos Malatras, Stephanie Duguez and William Duddy Tags: Software Source Type: research
RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy
Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To e... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 16, 2019 Category: Research Authors: Monica Llano-Diez, Wen Fury, Haruka Okamoto, Yu Bai, Jesper Gromada and Lars Larsson Tags: Research Source Type: research
IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway
Cancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition of muscle atrophy is a main strategy to treat cancer cachexia. In this process, myostatin (MSTN) can exert a du... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 28, 2019 Category: Research Authors: Dong Liu, Xinran Qiao, Zhijuan Ge, Yue Shang, Yi Li, Wendie Wang, Minghua Chen, Shuyi Si and Shu-zhen Chen Tags: Research Source Type: research
Critical reflections, challenges and solutions for migrant and refugee health: 2nd M8 Alliance Expert Meeting
Throughout recent years, we have witnessed an increase in human migration as a result of conflict, political instability and changes in the climate. Despite the growing number of migrants and refugees, provisi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 19, 2019 Category: Research Authors: Nefti-Eboni Bempong, Danny Sheath, Joachim Seybold, Antoine Flahault, Anneliese Depoux and Luciano Saso Tags: Meeting report Source Type: research
The ancient sarcomeric myosins found in specialized muscles
Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 5, 2019 Category: Research Authors: Lindsey A. Lee, Anastasia Karabina, Lindsey J. Broadwell and Leslie A. Leinwand Tags: Review Source Type: research
