Health professionals ’ perspectives on breast cancer risk stratification: understanding evaluation of risk versus screening for disease
Younger women at higher-than-population-average risk for breast cancer may benefit from starting screening earlier than presently recommended by the guidelines. The Personalized Risk Stratification for Prevent... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 28, 2019 Category: Research Authors: Svetlana Puzhko, Justin Gagnon, Jacques Simard, Bartha Maria Knoppers, Sophia Siedlikowski and Gillian Bartlett Tags: Review Source Type: research
Healthcare human resource development in Saudi Arabia: emerging challenges and opportunities —a critical review
Saudi Arabia is currently passing through a transformational phase. There is a huge demand on the Saudi healthcare system to provide better healthcare facilities to the rapidly increasing Saudi population, as ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 27, 2019 Category: Research Authors: Mohammed Khaled Al-Hanawi, Sami A. Khan and Hussein Mohammed Al-Borie Tags: Review Source Type: research
Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells
Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in thei... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 26, 2019 Category: Research Authors: Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie and Charles N. Pagel Tags: Research Source Type: research
Late-onset megaconial myopathy in mice lacking group I Paks
Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstr... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 21, 2019 Category: Research Authors: Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, Ren é L. Jacobs and Rob Tags: Research Source Type: research
Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation
Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 24, 2019 Category: Research Authors: Taejeong Song, Palanikumar Manoharan, Douglas P. Millay, Sheryl E. Koch, Jack Rubinstein, Judith A. Heiny and Sakthivel Sadayappan Tags: Research Source Type: research
Metabolic derangements of skeletal muscle from a murine model of glioma cachexia
Cachexia is a complex metabolic disorder and muscle atrophy syndrome, impacting 80% patients with advanced cancers. Malignant glioma is considered to be one of the deadliest human cancers, accounting for about... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 11, 2019 Category: Research Authors: Pengfei Cui, Wei Shao, Caihua Huang, Chang-Jer Wu, Bin Jiang and Donghai Lin Tags: Research Source Type: research
Open-CSAM, a new tool for semi-automated analysis of myofiber cross-sectional area in regenerating adult skeletal muscle
Adult skeletal muscle is capable of complete regeneration after an acute injury. The main parameter studied to assess muscle regeneration efficacy is the cross-sectional area (CSA) of the myofibers as myofiber... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 8, 2019 Category: Research Authors: Thibaut Desgeorges, Sophie Liot, Solene Lyon, Jessica Bouvi ère, Alix Kemmel, Aurélie Trignol, David Rousseau, Bruno Chapuis, Julien Gondin, Rémi Mounier, Bénédicte Chazaud and Gaëtan Juban Tags: Methodology Source Type: research
Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease
Niemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterat... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 5, 2019 Category: Research Authors: V. Michailowsky, H. Li, B. Mittra, S. R. Iyer, D. A. G. Maz ála, M. Corrotte, Y. Wang, E. R. Chin, R. M. Lovering and N. W. Andrews Tags: Research Source Type: research
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β2AR stimulation on skeletal muscle... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 27, 2018 Category: Research Authors: Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman and Robert J. Lefkowitz Tags: Research Source Type: research
The effect of antenatal care follow-up on neonatal health outcomes: a systematic review and meta-analysis
Neonatal mortality is one of the major public health problems throughout the world and most notably in developing countries. There exist inconclusive findings on the effect of antenatal care visits on neonatal... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 17, 2018 Category: Research Authors: Amsalu Taye Wondemagegn, Animut Alebel, Cheru Tesema and Worku Abie Tags: Review Source Type: research
Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury
Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on page 12 of the article. (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 10, 2018 Category: Research Authors: Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller Tags: Correction Source Type: research
The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis
Members of the ZFP36 family of RNA-binding proteins regulate gene expression post-transcriptionally by binding to AU-rich elements in the 3 ’UTR of mRNA and stimulating mRNA degradation. The proteins within thi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 7, 2018 Category: Research Authors: Hema Bye-A-Jee, Dhamayanthi Pugazhendhi, Samuel Woodhouse, Patrick Brien, Rachel Watson, Martin Turner and Jennifer Pell Tags: Research Source Type: research
Cardiovascular disease in racial/ethnic minority populations: illness burden and overview of community-based interventions
Cardiovascular disease, the leading cause of death in the USA, poses a unique and multilateral burden to racial/ethnic minorities. The admixture of comorbid conditions, structural barriers, and psychosocial st... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 3, 2018 Category: Research Authors: Brandon Muncan Tags: Review Source Type: research
Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOS μ
Loss of sarcolemmal nNOS μ is a common manifestation in a wide variety of muscle diseases and contributes to the dysregulation of multiple muscle activities. Given the critical role sarcolemmal nNOSμ plays in m... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 22, 2018 Category: Research Authors: Aman Patel, Junling Zhao, Yongping Yue, Keqing Zhang, Dongsheng Duan and Yi Lai Tags: Research Source Type: research
HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 13, 2018 Category: Research Authors: Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller Tags: Research Source Type: research
