DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older in... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 28, 2023 Category: Research Authors: Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey and Karen A. Lillycrop Tags: Research Source Type: research
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle satellite cells (MuSCs), a resident stem cell population responsible for postnatal regenera... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 13, 2023 Category: Research Authors: Stephanie N. Oprescu, Nick Baumann, Xiyue Chen, Qiang Sun, Yu Zhao, Feng Yue, Huating Wang and Shihuan Kuang Tags: Research Source Type: research
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutations in the DMD gene, leading to the absence of dystrophin. DMD results in muscle weakness, ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 13, 2023 Category: Research Authors: Marcelo dos Santos Voltani Lorena, Estela Kato dos Santos, Renato Ferretti, G. A. Nagana Gowda, Guy L. Odom, Jeffrey S. Chamberlain and Cintia Yuri Matsumura Tags: Research Source Type: research
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiological conditions, such as the response to different environments or myopathies. In this co... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 23, 2023 Category: Research Authors: Anne Danckaert, Aur élie Trignol, Guillaume Le Loher, Sébastien Loubens, Bart Staels, Hélène Duez, Spencer L. Shorte and Alicia Mayeuf-Louchart Tags: Software Source Type: research
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and fibre typing of skeletal muscle fibres, as seen during regeneration and in certain mus... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 12, 2023 Category: Research Authors: Grith H øjfeldt, Trent Sorenson, Alana Gonzales, Michael Kjaer, Jesper L. Andersen and Abigail L. Mackey Tags: Research Source Type: research
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to rise during critical illness. FGF21 is a pleiotropic hormone that mediates adaptive respo... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 4, 2023 Category: Research Authors: Wouter Vankrunkelsven, Steven Thiessen, Sarah Derde, Ellen Vervoort, Inge Derese, Isabel Pintelon, Hanne Matheussen, Alexander Jans, Chlo ë Goossens, Lies Langouche, Greet Van den Berghe and Ilse Vanhorebeek Tags: Research Source Type: research
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 12, 2023 Category: Research Authors: Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai and David J. Glass Tags: Research Source Type: research
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype –phenotype correlation
Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic defects. The genotype –phenotype correlation of this disease has been reported poorly. He... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 22, 2023 Category: Research Authors: Yuqing Guan, Xiongda Liang, Wei Li, Wanying Lin, Guanxia Liang, Hongting Xie, Yu Hou, Yafang Hu and Xuan Shang Tags: Research Source Type: research
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop severe... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 19, 2023 Category: Research Authors: Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates and Joseph M. Metzger Tags: Research Source Type: research
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two muscle-specific fusogens, Myomaker and Myomerg... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 1, 2023 Category: Research Authors: Phillip C. Witcher, Chengyi Sun and Douglas P. Millay Tags: Research Source Type: research
New tools for the investigation of muscle fiber-type spatial distributions across histological sections
The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers across the muscle belly. Many muscles feature a non-uniform spatial pattern of fiber types... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 22, 2023 Category: Research Authors: Anna K. Redmond, Tilman M. Davies, Matthew R. Schofield and Philip W. Sheard Tags: Methodology Source Type: research
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects. Whether extracellular vesicles (EVs) also play a role in the SkM... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 10, 2023 Category: Research Authors: Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond and Esther E. Dupont-Versteegden Tags: Research Source Type: research
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protein upregulated in dystrophic skeletal muscles. Based on gain- and loss-of-function studies we have p... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 7, 2023 Category: Research Authors: Clothilde Claus, Moriya Slavin, Eug énie Ansseau, Céline Lancelot, Karimatou Bah, Saskia Lassche, Manon Fiévet, Anna Greco, Sara Tomaiuolo, Alexandra Tassin, Virginie Dudome, Benno Kusters, Anne-Emilie Declèves, Dalila Laoudj-Chenivesse, Baziel G. M. Tags: Research Source Type: research
An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 2, 2023 Category: Research Authors: Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda and Marco Mangone Tags: Methodology Source Type: research
Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle
Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfusion. Myofibers and microvessels regenerate from satellite cells and from surviving m... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 14, 2023 Category: Research Authors: Nicole L. Jacobsen, Aaron B. Morton and Steven S. Segal Tags: Research Source Type: research
