Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the defining characteristic of ALS, the events ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 23, 2016 Category: Research Authors: Donald Beqollari, Christin F. Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A. Voss, Antonio Musarò and Roger A. Bannister Source Type: research
Treatment with rGDF11 does not improve the dystrophic muscle pathology of mdx mice
Duchenne muscular dystrophy (DMD) is an inherited lethal muscle wasting disease characterized by cycles of degeneration and regeneration, with no effective therapy. Growth differentiation factor 11 (GDF11), a ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 14, 2016 Category: Research Authors: Fabrizio Rinaldi, Yu Zhang, Ricardo Mondragon-Gonzalez, Jeffrey Harvey and Rita C. R. Perlingeiro Source Type: research
Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy
Secondary dystroglycanopathies are a subset of muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (αDG). Loss of αDG functional glycosylation prevents it from binding to laminin and other ex... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 2, 2016 Category: Research Authors: Steven J. Foltz, Junna Luan, Jarrod A. Call, Ankit Patel, Kristen B. Peissig, Marisa J. Fortunato and Aaron M. Beedle Source Type: research
The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration
Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its dual role as an epigenetic regulator and in the regula... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 27, 2016 Category: Research Authors: Regan-Heng Zhang, Robert N. Judson, David Y. Liu, Jürgen Kast and Fabio M. V. Rossi Source Type: research
Erratum to: The beneficial role of proteolysis in skeletal muscle growth and stress adaptation
(Source: Skeletal Muscle)
Source: Skeletal Muscle - May 4, 2016 Category: Research Authors: Ryan A. V. Bell, Mohammad Al-Khalaf and Lynn A. Megeney Source Type: research
Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction
Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 2, 2016 Category: Research Authors: Molly H. Jenkins, Sarah S. Alrowaished, Michelle F. Goody, Bryan D. Crawford and Clarissa A. Henry Source Type: research
The SH3 and cysteine-rich domain 3 (Stac3) gene is important to growth, fiber composition, and calcium release from the sarcoplasmic reticulum in postnatal skeletal muscle
In this study, we determined the potential role of Stac3 in postnatal skeleta... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 11, 2016 Category: Research Authors: Xiaofei Cong, Jonathan Doering, Davi A. G. Mazala, Eva R. Chin, Robert W. Grange and Honglin Jiang Source Type: research
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
Electrical activity regulates the expression of skeletal muscle genes by a process known as “excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) durin... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 11, 2016 Category: Research Authors: Manuel Arias-Calderón, Gonzalo Almarza, Alexis Díaz-Vegas, Ariel Contreras-Ferrat, Denisse Valladares, Mariana Casas, Héctor Toledo, Enrique Jaimovich and Sonja Buvinic Source Type: research
The beneficial role of proteolysis in skeletal muscle growth and stress adaptation
Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown often overshadow the critical nature ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 6, 2016 Category: Research Authors: Ryan A. V. Bell, Mohammad Al-Khalaf and Lynn A. Megeney Source Type: research
Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures
Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 4, 2016 Category: Research Authors: Joe N. Kornegay, Daniel J. Bogan, Janet R. Bogan, Jennifer L. Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C. Warsing, Robert W. Grange, Mihye Ahn, Cynthia J. Balog-Alvarez, Steven W. Cotten, Monte S. Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Source Type: research
Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis
Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglyce... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 30, 2016 Category: Research Authors: Brianna D. Harfmann, Elizabeth A. Schroder, Maureen T. Kachman, Brian A. Hodge, Xiping Zhang and Karyn A. Esser Source Type: research
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pathways controlling cell growth and survival. This multiprotein complex integrates external signals and affects... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 21, 2016 Category: Research Authors: Maitea Guridi, Barbara Kupr, Klaas Romanino, Shuo Lin, Denis Falcetta, Lionel Tintignac and Markus A. Rüegg Source Type: research
Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 15, 2016 Category: Research Authors: Jessica Segalés, Abul B. M. M. K. Islam, Roshan Kumar, Qi-Cai Liu, Pedro Sousa-Victor, F. Jeffrey Dilworth, Esteban Ballestar, Eusebio Perdiguero and Pura Muñoz-Cánoves Source Type: research
Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway
Hypoxia exposure is known to induce an alteration in skeletal muscle fiber-type distribution mediated by hypoxia-inducible factor (HIF)-α. The downstream pathway of HIF-α leading to fiber-type shift, however, ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 5, 2016 Category: Research Authors: Junchul Shin, Aki Nunomiya, Yasuo Kitajima, Takashi Dan, Toshio Miyata and Ryoichi Nagatomi Source Type: research
Neuromuscular electrical stimulation promotes development in mice of mature human muscle from immortalized human myoblasts
Studies of the pathogenic mechanisms underlying human myopathies and muscular dystrophies often require animal models, but models of some human diseases are not yet available. Methods to promote the engraftmen... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 27, 2016 Category: Research Authors: Paraskevi Sakellariou, Andrea O’Neill, Amber L. Mueller, Guido Stadler, Woodring E. Wright, Joseph A. Roche and Robert J. Bloch Source Type: research
