Six1 promotes skeletal muscle thyroid hormone response through regulation of the MCT10 transporter
The Six1 transcription factor is implicated in controlling the development of several tissue types, notably skeletal muscle. Six1 also contributes to muscle metabolism and its activity is associated with the fast... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 19, 2021 Category: Research Authors: John Girgis, Dabo Yang, Imane Chakroun, Yubing Liu and Alexandre Blais Tags: Research Source Type: research
The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies
As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 12, 2021 Category: Research Authors: Hongyang Xu and Holly Van Remmen Tags: Review Source Type: research
Protein profile of fiber types in human skeletal muscle: a single-fiber proteomics study
Human skeletal muscle is composed of three major fiber types, referred to as type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the interpretation of studies based on whole skeletal... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 2, 2021 Category: Research Authors: Marta Murgia, Leonardo Nogara, Martina Baraldo, Carlo Reggiani, Matthias Mann and Stefano Schiaffino Tags: Research Source Type: research
Improved CRISPR/Cas9 gene editing in primary human myoblasts using low confluency cultures on Matrigel
CRISPR/Cas9 is an invaluable tool for studying cell biology and the development of molecular therapies. However, delivery of CRISPR/Cas9 components into some cell types remains a major hurdle. Primary human my... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 22, 2021 Category: Research Authors: Hayley Goull ée, Rhonda L. Taylor, Alistair R. R. Forrest, Nigel G. Laing, Gianina Ravenscroft and Joshua S. Clayton Tags: Methodology Source Type: research
Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias
Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 4, 2021 Category: Research Authors: Robert W. Arpke, Ahmed S. Shams, Brittany C. Collins, Alexie A. Larson, Nguyen Lu, Dawn A. Lowe and Michael Kyba Tags: Research Source Type: research
Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weak... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 3, 2021 Category: Research Authors: Olga Mucha, Paulina Podkalicka, Katarzyna Kazir ód, Emilia Samborowska, Józef Dulak and Agnieszka Łoboda Tags: Research Source Type: research
Investigating the correlation of muscle function tests and sarcomere organization in C. elegans
Caenorhabditis elegans has been widely used as a model to study muscle structure and function. Its body wall muscle is functionally and structurally similar to vertebrate skeletal muscle with conserved molecular ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - August 13, 2021 Category: Research Authors: Leila Lesanpezeshki, Hiroshi Qadota, Masoud Norouzi Darabad, Karishma Kashyap, Carla M. R. Lacerda, Nathaniel J. Szewczyk, Guy M. Benian and Siva A. Vanapalli Tags: Research Source Type: research
The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
In the search of genetic determinants of Duchenne muscular dystrophy (DMD) severity, LTBP4, a member of the latent TGF- β binding protein family, emerged as an important predictor of functional outcome trajectorie... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 22, 2021 Category: Research Authors: Simonetta Andrea Licandro, Luca Crippa, Roberta Pomarico, Raffaella Perego, Gianluca Fossati, Flavio Leoni and Christian Steink ühler Tags: Research Source Type: research
mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation
During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. Cellular/mitotic quiescence employs mechanisms that prom... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 8, 2021 Category: Research Authors: Nainita Roy, Swetha Sundar, Malini Pillai, Farah Patell-Socha, Sravya Ganesh, Ajoy Aloysius, Mohammed Rumman, Hardik Gala, Simon M. Hughes, Peter S. Zammit and Jyotsna Dhawan Tags: Research Source Type: research
Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release
Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-r... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 6, 2021 Category: Research Authors: Lin Zhou, Tong Zhang, Wei Shao, Ruohan Lu, Lin Wang, Haisheng Liu, Bin Jiang, Shiqin Li, Huiqin Zhuo, Suheng Wang, Qinxi Li, Caihua Huang and Donghai Lin Tags: Research Source Type: research
Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors —time for new definitions
Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism —all the functions needed for an individual’s health and well-being. The muscle connective ti... (Source: Skeletal Muscle)
Source: Skeletal Muscle - July 1, 2021 Category: Research Authors: Osvaldo Contreras, Fabio M. V. Rossi and Marine Theret Tags: Review Source Type: research
Niclosamide ethanolamine ameliorates diabetes-related muscle wasting by inhibiting autophagy
Diabetes-related muscle wasting is one of the devastating complications of diabetes, which is associated with muscle autophagy due to insulin-mediated glucose starvation. However, treatment for diabetes-relate... (Source: Skeletal Muscle)
Source: Skeletal Muscle - June 9, 2021 Category: Research Authors: Yuchun Cai, Hongyue Zhan, Wenci Weng, Yao Wang, Pengxun Han, Xuewen Yu, Mumin Shao and Huili Sun Tags: Research Source Type: research
Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis
The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4). Because IL-4 is an esse... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 29, 2021 Category: Research Authors: Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda and Toshiya Funabashi Tags: Research Source Type: research
Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers
Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression data is generally based upon single nucleus RNA, rath... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 17, 2021 Category: Research Authors: Rohan X. Verma, Suraj Kannan, Brian L. Lin, Katherine M. Fomchenko, Tim O. Nieuwenhuis, Arun H. Patil, Clarisse Lukban, Xiaoping Yang, Karen Fox-Talbot, Matthew N. McCall, Chulan Kwon, David A. Kass, Avi Z. Rosenberg and Marc K. Halushka Tags: Research Source Type: research
Nanopattern surface improves cultured human myotube maturation
In vitro maturation of human primary myoblasts using 2D culture remains a challenging process and leads to immature fibers with poor internal organization and function. This would however represent a valuable sys... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 5, 2021 Category: Research Authors: Jessica Brunetti, St éphane Koenig, Arthur Monnier and Maud Frieden Tags: Methodology Source Type: research
