Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study
Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation (CMV) and suggested to be due to the hyperinflammatory response associ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - May 3, 2021 Category: Research Authors: Qiong Lyu, Ya Wen, Xiang Zhang, Alex B. Addinsall, Nicola Cacciani and Lars Larsson Tags: Research Source Type: research
Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature
SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakne... (Source: Skeletal Muscle)
Source: Skeletal Muscle - April 21, 2021 Category: Research Authors: Badrul Islam, Mohiuddin Ahmed, Zhahirul Islam and S. M. Begum Tags: Case report Source Type: research
Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
An amendment to this paper has been published and can be accessed via the original article. (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 30, 2021 Category: Research Authors: Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Tags: Retraction Note Source Type: research
Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgeni... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 30, 2021 Category: Research Authors: Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui and Rongzhang He Tags: Research Source Type: research
A novel approach for the isolation and long-term expansion of pure satellite cells based on ice-cold treatment
Satellite cells (SCs) are muscle stem cells capable of regenerating injured muscle. The study of their functional potential depends on the availability of methods for the isolation and expansion of pure SCs wi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 17, 2021 Category: Research Authors: Anna Benedetti, Gianluca Cera, Daniele De Meo, Ciro Villani, Marina Bouche and Biliana Lozanoska-Ochser Tags: Methodology Source Type: research
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation
Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effectiveness. We sought to investigate the role of miR-1290 in myoblast differ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - March 15, 2021 Category: Research Authors: Ji Che, Cuidi Xu, Yuanyuan Wu, Peiyu Jia, Qi Han, Yantao Ma, Xiaolei Wang and Yongjun Zheng Tags: Research Source Type: research
Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse
Myogenin is a transcription factor that is expressed during terminal myoblast differentiation in embryonic development and adult muscle regeneration. Investigation of this cell state transition has been hampered ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 18, 2021 Category: Research Authors: Maria Benavente-Diaz, Glenda Comai, Daniela Di Girolamo, Francina Langa and Shahragim Tajbakhsh Tags: Methodology Source Type: research
Epigenetic regulation of satellite cell fate during skeletal muscle regeneration
In response to muscle injury, muscle stem cells integrate environmental cues in the damaged tissue to mediate regeneration. These environmental cues are tightly regulated to ensure expansion of muscle stem cel... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 11, 2021 Category: Research Authors: Jimmy Massenet, Edward Gardner, B énédicte Chazaud and F. Jeffrey Dilworth Tags: Review Source Type: research
Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D
A cohort of related miniature dachshund dogs with exercise intolerance, stiff gait, dysphagia, myoglobinuria, and markedly elevated serum creatine kinase activities were identified. (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 7, 2021 Category: Research Authors: James R. Mickelson, Katie M. Minor, Ling T. Guo, Steven G. Friedenberg, Jonah N. Cullen, Amanda Ciavarella, Lydia E. Hambrook, Karen M. Brenner, Sarah E. Helmond, Stanley L. Marks and G. Diane Shelton Tags: Research Source Type: research
Muscle spindle function in healthy and diseased muscle
Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this i... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 7, 2021 Category: Research Authors: Stephan Kr öger and Bridgette Watkins Tags: Review Source Type: research
Analysis of human satellite cell dynamics on cultured adult skeletal muscle myofibers
Maintaining stem cells in physiologically relevant states is necessary to understand cell and context-specific signalling paradigms and to understand complex interfaces between cells in situ. Understanding hum... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 4, 2021 Category: Research Authors: Peter Feige, Eve C. Tsai and Michael A. Rudnicki Tags: Methodology Source Type: research
Mitochondrial dysfunction and consequences in calpain-3-deficient muscle
Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 11, 2020 Category: Research Authors: Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van Der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal and Kanneboyina Nagaraju Tags: Research Source Type: research
The role of Nrf2 in acute and chronic muscle injury
The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 8, 2020 Category: Research Authors: Iwona Bronisz-Budzy ńska, Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda and Józef Dulak Tags: Research Source Type: research
Meeting report: the 2020 FSHD International Research Congress
(Source: Skeletal Muscle)
Source: Skeletal Muscle - December 8, 2020 Category: Research Authors: Michael Kyba, Robert J. Bloch, Julie Dumonceaux, Scott Q. Harper, Silv ère M. van der Maarel, Francis M. Sverdrup, Kathryn R. Wagner, Baziel van Engelen and Yi-Wen Chen Tags: Meeting report Source Type: research
Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function
Tetraspanins are a family of proteins known to assemble protein complexes at the cell membrane. They are thought to play diverse cellular functions in tissues by modifying protein-binding partners, thus bringi... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 27, 2020 Category: Research Authors: Arielle Hall, Tatiana Fontelonga, Alec Wright, Katlynn Bugda Gwilt, Jeffrey Widrick, Alessandra Pasut, Francesco Villa, Cynthia K. Miranti, Devin Gibbs, Evan Jiang, Hui Meng, Michael W. Lawlor and Emanuela Gussoni Tags: Research Source Type: research
