A novel in vitro model for the assessment of postnatal myonuclear accretion
Due to the post-mitotic nature of myonuclei, postnatal myogenesis is essential for skeletal muscle growth, repair, and regeneration. This process is facilitated by satellite cells through proliferation, differ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - February 14, 2018 Category: Research Authors: Anita Kneppers, Lex Verdijk, Chiel de Theije, Mark Corten, Ellis Gielen, Luc van Loon, Annemie Schols and Ramon Langen Tags: Methodology Source Type: research
Myoblast fusion confusion: the resolution begins
The fusion of muscle precursor cells is a required event for proper skeletal muscle development and regeneration. Numerous proteins have been implicated to function in myoblast fusion; however, the majority ar... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 31, 2018 Category: Research Authors: Srihari C. Sampath, Srinath C. Sampath and Douglas P. Millay Tags: Review Source Type: research
Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei
Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog DUX4c are induced. DUX4c is immunodetected in every my... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 12, 2018 Category: Research Authors: C éline Vanderplanck, Alexandra Tassin, Eugénie Ansseau, Sébastien Charron, Armelle Wauters, Céline Lancelot, Kelly Vancutsem, Dalila Laoudj-Chenivesse, Alexandra Belayew and Frédérique Coppée Tags: Research Source Type: research
Development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes
Human induced pluripotent stem cells-derived myogenic progenitors develop functional and ultrastructural features typical of skeletal muscle when differentiated in culture. Besides disease-modeling, such a sys... (Source: Skeletal Muscle)
Source: Skeletal Muscle - January 5, 2018 Category: Research Authors: Jeanne Lain é, Gunnar Skoglund, Emmanuel Fournier and Nacira Tabti Tags: Research Source Type: research
Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
Type 1 diabetes mellitus (T1DM) induces serious skeletal muscle atrophy. Low-intensity pulsed ultrasound (LIPUS) is a common treatment for skeletal muscle injury and is effective in accelerating the rate of mu... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 22, 2017 Category: Research Authors: Liang Tang, Nan Li, Wenqi Jian, Yiting Kang, Bo Yin, Shuxin Sun, Jianzhong Guo, Lijun Sun and Dean Ta Tags: Research Source Type: research
Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells
Skeletal muscle satellite (stem) cells are quiescent in adult mice and can undergo multiple rounds of proliferation and self-renewal following muscle injury. Several labs have profiled transcripts of myogenic ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 22, 2017 Category: Research Authors: Natalia Pietrosemoli, S ébastien Mella, Siham Yennek, Meryem B. Baghdadi, Hiroshi Sakai, Ramkumar Sambasivan, Francesca Pala, Daniela Di Girolamo and Shahragim Tajbakhsh Tags: Research Source Type: research
Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis
Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle. (Source: Skeletal Muscle)
Source: Skeletal Muscle - December 14, 2017 Category: Research Authors: Mehmet E. Yalvac, Jakkrit Amornvit, Cilwyn Braganza, Lei Chen, Syed-Rehan A. Hussain, Kimberly M. Shontz, Chrystal L. Montgomery, Kevin M. Flanigan, Sarah Lewis and Zarife Sahenk Tags: Research Source Type: research
Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans
The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 16, 2017 Category: Research Authors: Xiao Hu, James P. Charles, Turgay Akay, John R. Hutchinson and Silvia S. Blemker Tags: Research Source Type: research
A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys
The treatments currently approved for Duchenne muscular dystrophy (DMD), a progressive skeletal muscle wasting disease, address the needs of only a small proportion of patients resulting in an urgent need for ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 9, 2017 Category: Research Authors: Michael St. Andre, Mark Johnson, Prashant N. Bansal, Jeremy Wellen, Andrew Robertson, Alan Opsahl, Peter M. Burch, Peter Bialek, Carl Morris and Jane Owens Tags: Research Source Type: research
The breaking and making of healthy adult human skeletal muscle in vivo
While muscle regeneration has been extensively studied in animal and cell culture models, in vivo myogenesis in adult human skeletal muscle has not been investigated in detail. (Source: Skeletal Muscle)
Source: Skeletal Muscle - November 7, 2017 Category: Research Authors: Abigail L. Mackey and Michael Kjaer Tags: Research Source Type: research
Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice
Chronic increases in the levels of the inflammatory cytokine interleukin-6 (IL-6) in serum and skeletal muscle are thought to contribute to the progression of muscular dystrophy. Dystrophin/utrophin double-kno... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 27, 2017 Category: Research Authors: Eiji Wada, Jun Tanihata, Akira Iwamura, Shin ’ichi Takeda, Yukiko K. Hayashi and Ryoichi Matsuda Tags: Research Source Type: research
Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle
Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein. Increasing the levels of the dystrophin-related-protein ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 24, 2017 Category: Research Authors: Tahnee L. Kennedy, Lee Moir, Sarah Hemming, Ben Edwards, Sarah Squire, Kay Davies and Simon Guiraud Tags: Research Source Type: research
Loss of MKP-5 promotes myofiber survival by activating STAT3/Bcl-2 signaling during regenerative myogenesis
The mitogen-activated protein kinases (MAPKs) have been shown to be involved in regulating myofiber survival. In skeletal muscle, p38 MAPK and JNK are negatively regulated by MAPK phosphatase-5 (MKP-5). During... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 18, 2017 Category: Research Authors: Kisuk Min, Ahmed Lawan and Anton M. Bennett Tags: Research Source Type: research
HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway
The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a solu... (Source: Skeletal Muscle)
Source: Skeletal Muscle - October 10, 2017 Category: Research Authors: Mariela Natacha Gonz ález, Wallace de Mello, Gillian S. Butler-Browne, Suse Dayse Silva-Barbosa, Vincent Mouly, Wilson Savino and Ingo Riederer Tags: Research Source Type: research
Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin expression and leads to severe ambulatory and cardiac function decline. However, the dystrophin-deficient mdx murine model of DMD only develops a ... (Source: Skeletal Muscle)
Source: Skeletal Muscle - September 12, 2017 Category: Research Authors: Nadia Milad, Zoe White, Arash Y. Tehrani, Stephanie Sellers, Fabio M.V. Rossi and Pascal Bernatchez Tags: Research Source Type: research
