Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9

Conclusions:
Our findings identify differences between AAV6 and AAV9 for myofiber-type preferences, which could be an underlying factor for mosaic transduction of skeletal muscle. Adjusting AAV serotype for specific muscle conditions can therefore improve transduction efficacy in clinical applications.

Source: Skeletal Muscle - November 10, 2015 Category: Research Authors: Muhammad RiazYotam RazElizabeth MoloneyMaaike van PuttenYvonne D. KromSilvere van der MaarelJoost VerhaagenVered Raz Source Type: research