Reviews in Endocrine and Metabolic Disorders This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Targeting aging with the healthy skeletal system: The endocrine role of bone
AbstractAging is an inevitable biological process, and longevity may be related to bone health. Maintaining strong bone health can extend one ’s lifespan, but the exact mechanism is unclear. Bone and extraosseous organs, including the heart and brain, have complex and precise communication mechanisms. In addition to its load bearing capacity, the skeletal system secretes cytokines, which play a role in bone regulation of extraosseous or gans. FGF23, OCN, and LCN2 are three representative bone-derived cytokines involved in energy metabolism, endocrine homeostasis and systemic chronic inflammation levels. Today, advanced r...
Source: Reviews in Endocrine and Metabolic Disorders - July 5, 2023 Category: Endocrinology Source Type: research

Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
AbstractObesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight management do not address biological heterogeneity between individuals and have catastrophically failed to combat the global pandemic of obesity-related diseases. Nutritional strategies that extend beyond basic weight management to instead target patient-specific pathophysiology are warranted. In this narrative review, we provide an overview of the tissue-level pathophysiological processes that drive patient heterogeneity to shape distinct cardiometabolic phenotypes in obesity...
Source: Reviews in Endocrine and Metabolic Disorders - July 5, 2023 Category: Endocrinology Source Type: research

Management of radioiodine refractory differentiated thyroid cancer: the Latin American perspective
AbstractRadioiodine (RAI) refractory differentiated thyroid cancer is an uncommon and challenging situation that requires a multidisciplinary approach to therapeutic strategies. The definition of RAI-refractoriness is usually a clear situation in specialized centers. However, the right moment for initiation of multikinase inhibitors (MKI), the time and availability for genomic testing, and the possibility of prescribing MKI and selective kinase inhibitors differ worldwide.Latin America (LA) refers to the territories of the world that stretch across two regions: North America (including Central America and the Caribbean) an...
Source: Reviews in Endocrine and Metabolic Disorders - June 29, 2023 Category: Endocrinology Source Type: research

Hidden chronic metabolic acidosis of diabetes type 2 (CMAD): Clues, causes and consequences
AbstractInterpretation of existing data revealed that chronic metabolic acidosis is a pathognomic feature for type 2 diabetes (T2D), which is described here as “chronic metabolic acidosis of T2D (CMAD)” for the first time. The biochemical clues for the CMAD are summarised in the following; low blood bicarbonate (high anionic gap), low pH of interstitial fluid and urine, and response to acid neutralization, while the causes of extra protons are worked o ut to be; mitochondrial dysfunction, systemic inflammation, gut microbiota (GM), and diabetic lung. Although, the intracellular pH is largely preserved by the buffer sys...
Source: Reviews in Endocrine and Metabolic Disorders - June 28, 2023 Category: Endocrinology Source Type: research

Obesity phenotypes and cardiovascular risk: From pathophysiology to clinical management
AbstractObesity epidemic reached the dimensions of a real global health crisis with more than one billion people worldwide living with obesity. Multiple obesity-related mechanisms cause structural, functional, humoral, and hemodynamic alterations with cardiovascular (CV) deleterious effects. A correct assessment of the cardiovascular risk in people with obesity is critical for reducing mortality and preserving quality of life. The correct identification of the obesity status remains difficult as recent evidence suggest that different phenotypes of obesity exist, each one associated with different degrees of CV risk. Diagno...
Source: Reviews in Endocrine and Metabolic Disorders - June 26, 2023 Category: Endocrinology Source Type: research

The influence of stress on the neural underpinnings of disinhibited eating: a systematic review and future directions for research
AbstractDisinhibited eating involves overconsumption and loss of control over food intake, and underpins many health conditions, including obesity and binge-eating related disorders. Stress has been implicated in the development and maintenance of disinhibited eating behaviours, but the mechanisms underlying this relationship are unclear. In this systematic review, we examined how the impact of stress on the neurobiological substrates of food-related reward sensitivity, interoception and cognitive control explains its role in disinhibited eating behaviours. We synthesised the findings of functional magnetic resonance imagi...
Source: Reviews in Endocrine and Metabolic Disorders - June 13, 2023 Category: Endocrinology Source Type: research

Phase angle and COVID-19: A systematic review with meta-analysis
This study aimed to achieve a systematic review, where we discussed the potential role of PhA value as a prognostic marker of adverse clinical outcomes such as mortality and complication in hospitalized with SARS-CoV2 infection and established the strength of recommendations for use. A systematic literature review with meta-analysis was done in the main electronic databases from 2020 to January 2023. The selected articles had to investigate adverse consequences of the COVID-19 population and raw bioimpedance parameters such as PhA and published in peer-reviewed journals. GRADE tools regarded the quality of the methodology....
Source: Reviews in Endocrine and Metabolic Disorders - June 1, 2023 Category: Endocrinology Source Type: research

Applying psycho-behavioural phenotyping in obesity characterization
AbstractIndividual differences in obesity, beyond being explained by metabolic and medical complications, are understood by alterations in eating behaviour which underlie psychological processes. From this psychological perspective, studies have identified several potential characteristic features at the psycho-behavioural level that could additionally explain the maintenance of chronic excess weight or the unsuccessful results of current treatments. To date, despite the growing evidence, the heterogeneity of the psychological evidence associated with obesity has made it challenging to generate consensus on whether these p...
Source: Reviews in Endocrine and Metabolic Disorders - June 1, 2023 Category: Endocrinology Source Type: research

Phase angle in applications of bioimpedance in health and disease
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - June 1, 2023 Category: Endocrinology Source Type: research

Prevalence and significance of indeterminate calcitonin values in patients with thyroid nodules: A systematic review and meta-analysis
ConclusionsThe percentage of ICV among patients with thyroid nodules who underwent Ctn testing is negligible. The rate of MTC in patients with ICV cannot be overlooked. Among the ICV intervals, the risk of MTC increases significantly when Ctn is above 20 pg/mL. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - May 31, 2023 Category: Endocrinology Source Type: research

Effects of GLP-1 receptor agonists on neurological complications of diabetes
AbstractEmerging evidence suggests that treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) could be an interesting treatment strategy to reduce neurological complications such as stroke, cognitive impairment, and peripheral neuropathy. We performed a systematic review to examine the evidence concerning the effects of GLP-1 RAs on neurological complications of diabetes. The databases used were Pubmed, Scopus and Cochrane. We selected clinical trials which analysed the effect of GLP-1 RAs on stroke, cognitive impairment, and peripheral neuropathy. We found a total of 19 studies: 8 studies include stroke or ...
Source: Reviews in Endocrine and Metabolic Disorders - May 26, 2023 Category: Endocrinology Source Type: research