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The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review
AbstractGastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
AbstractOsteoarthritis (OA) is an incapacitating and one of the most common physically degenerative conditions with an assorted etiology and a highly complicated molecular mechanism that to date lacks an efficient treatment. The capacity to design biological networks and accurately modify existing genomic sites holds an apt potential for applications across medical and biotechnological sciences. One of these highly specific genomes editing technologies is the CRISPR/Cas9 mechanism, referred to as the clustered regularly interspaced short palindromic repeats, which is a defense mechanism constituted by CRISPR associated pro...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
AbstractAs the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hypersecretion and inhibiting tumor growth, improving progression-free survival and overall surv...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
AbstractDaily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4  weeks. 20 studies were included in the qualitative systematic review, and ...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
AbstractDiabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the vasculature. Attenuation of this pathological remodeling of blood vessels remains an unmet target owing to paucity of information on the metabolic signatures of this process. Ca2+/calmodulin-dependent kinase II (CaMKII) is expressed in the vasculature and is implicated in the control of blood vessels homeostasis. Recently, CaMKII has attracted a special attention in view of its chronic upregulated activity in diabetic tissues, yet its role in the diabetic vasculature rem...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

Correction to: Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research

A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence
AbstractBariatric surgery is widely recognized as the most effective intervention for obesity and offers benefits beyond weight loss. However, not all patients achieve satisfactory weight loss, balanced changes in body composition, and resolution of comorbidities. Therefore, thorough pre- and postoperative evaluations are important to predict success and minimize adverse effects. More comprehensive assessments require broadening the focus beyond body weight and fat measurements to consider quantitative and qualitative evaluations of muscles. Introducing the concept of sarcopenia is useful for assessing the degradative and ...
Source: Reviews in Endocrine and Metabolic Disorders - March 1, 2024 Category: Endocrinology Source Type: research

Diagnosis and management of secondary adrenal crisis
AbstractAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventive strategies, its prevalence is increasing in patients with SAI, TAI and IAI due to more freq...
Source: Reviews in Endocrine and Metabolic Disorders - February 27, 2024 Category: Endocrinology Source Type: research

The changing landscape of acromegaly  – an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: Reviews in Endocrine and Metabolic Disorders - February 10, 2024 Category: Endocrinology Source Type: research

Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist?
AbstractCentral hypothyroidism (CH) is characterized by decreased thyroid hormone production due to insufficient stimulation of an otherwise normal thyroid gland by TSH. In patients with established hypothalamic-pituitary disease, a low FT4 concentration is considered highly specific, although poorly sensitive, for the diagnosis of CH. That would be comparable to diagnosing primary hypothyroidism in patients at risk only when serum FT4 concentrations are below the reference range, missing all patients with subclinical primary hypothyroidism and preventing proper therapy in patients in which thyroxine replacement is clearly...
Source: Reviews in Endocrine and Metabolic Disorders - February 7, 2024 Category: Endocrinology Source Type: research