Reviews in Endocrine and Metabolic Disorders This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mortality and morbidity in ageing men: Biology, Lifestyle and Environment
AbstractMales live shorter lives than women in all countries. The universality of shorter male life expectancy is a 21st Century phenomena. It occurs with the decline in infectious diseases and the rise in cardiovascular diseases accounting for mortality. Male/female differences in morbidity are not as succinctly characterized. Men have a higher prevalence of lethal diseases, which is linked to their lower life expectancy. Women have more non-lethal conditions such as depression and arthritis; which may also be linked in part to longer survival. Men have better physical functioning and less disability which is partly expla...
Source: Reviews in Endocrine and Metabolic Disorders - December 1, 2022 Category: Endocrinology Source Type: research

The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities
AbstractNeuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal, pancreatic, and pulmonary tissues, and despite being rare, show rising incidence. The molecular mechanisms underlying NEN development are still poorly understood, although recent studies are unveiling their genomic, epigenomic and transcriptomic landscapes. RNA was originally considered as an intermediary between DNA and protein. Today, compelling evidence underscores the regulatory relevance of RNA processing, while new RNA molecules emerge with ...
Source: Reviews in Endocrine and Metabolic Disorders - November 24, 2022 Category: Endocrinology Source Type: research

The role of testosterone, the androgen receptor, and hypothalamic-pituitary –gonadal axis in depression in ageing Men
AbstractConsiderable research has shown that testosterone regulates many physiological systems, modulates clinical disorders, and contributes to health outcome. However, studies on the interaction of testosterone levels with depression and the antidepressant effect of testosterone replacement therapy in hypogonadal men with depression have been inconclusive. Current findings indicate that low circulating levels of total testosterone meeting stringent clinical criteria for hypogonadism and testosterone deficiency induced by androgen deprivation therapy are associated with increased risk for depression and current depressive...
Source: Reviews in Endocrine and Metabolic Disorders - November 22, 2022 Category: Endocrinology Source Type: research

Pregnancy in patients with adrenocortical carcinoma: a case-based discussion
AbstractAlthough adrenocortical carcinoma (ACC) during pregnancy is rare, a retrospective review of a case series at our hospital revealed that almost one third of our patients were women in childbearing age. Given that the age of maternity is increasing, dealing with a tumor diagnosis during pregnancy and the need for fertility planning in cancer survivors is likely to become more frequent.We thus carried out a case-based discussion regarding: i) diagnosing and treating an ACC during pregnancy; ii) patients conceiving while on mitotane; iii) ACC survivors with a maternal desire.In each of these cases, it is important to p...
Source: Reviews in Endocrine and Metabolic Disorders - November 22, 2022 Category: Endocrinology Source Type: research

The management of congenital adrenal hyperplasia during preconception, pregnancy, and postpartum
AbstractCongenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders of steroidogenesis of the adrenal cortex, most commonly due to 21-hydroxylase deficiency caused by mutations in theCYP21A2 gene. Although women with CAH have decreased fecundity, they are able to conceive; thus, if pregnancy is not desired, contraception options should be offered. If fertility is desired, women with classic CAH should first optimize glucocorticoid treatment, followed by ovulation induction medications and gonadotropins if needed. Due to the possible pregnancy complications and implications on the offspring, preconcepti...
Source: Reviews in Endocrine and Metabolic Disorders - November 18, 2022 Category: Endocrinology Source Type: research

Extracellular-matrix mechanics regulate cellular metabolism: A ninja warrior behind mechano-chemo signaling crosstalk
AbstractMechanical forces are the indispensable constituent of environmental cues, such as gravity, barometric pressure, vibration, and contact with bodies, which are involved in pattern and organogenesis, providing mechanical input to tissues and determining the ultimate fate of cells. Extracellular matrix (ECM) stiffness, the slow elastic force, carries the external physical force load onto the cell or outputs the internal force exerted by the cell and its neighbors into the environment. Accumulating evidence illustrates the pivotal role of ECM stiffness in the regulation of organogenesis, maintenance of tissue homeostas...
Source: Reviews in Endocrine and Metabolic Disorders - November 17, 2022 Category: Endocrinology Source Type: research

The anabolic applications of androgens in older adults with functional limitations
AbstractAging is associated with a progressive decrease in skeletal muscle mass, strength and power and impairment of physical function. Serum testosterone concentrations in men decrease with advancing age due to defects at all levels of the hypothalamic-pituitary –testicular axis. Testosterone administration increases skeletal muscle mass, strength and power in older men with low or low normal testosterone levels, but the effects on performance-based measures of physical function have been inconsistent. Adequately powered randomized trials are needed to de termine the long-term safety and efficacy of testosterone in imp...
Source: Reviews in Endocrine and Metabolic Disorders - November 10, 2022 Category: Endocrinology Source Type: research

Diagnosis of hypogonadism in ageing men
AbstractTo make the diagnosis of hypogonadism in an ageing man, in absence of rare organic cause often referred to as functional or late onset hypogonadism (LOH), he should present with a clinical syndrome suggestive of androgen deficiency and have consistently low serum testosterone (T) levels. This does not differ from the diagnosis of any other form of hypogonadism. Particular to LOH diagnostic are uncertainties surrounding this entity: signs and symptoms of androgen deficiency (including sexual symptoms) are nonspecific in older men; clinical significance of only moderately low T levels is uncertain; comorbidity plays ...
Source: Reviews in Endocrine and Metabolic Disorders - November 10, 2022 Category: Endocrinology Source Type: research

The anabolic applications of androgens in older adults with functional limitations
AbstractAging is associated with a progressive decrease in skeletal muscle mass, strength and power and impairment of physical function. Serum testosterone concentrations in men decrease with advancing age due to defects at all levels of the hypothalamic-pituitary –testicular axis. Testosterone administration increases skeletal muscle mass, strength and power in older men with low or low normal testosterone levels, but the effects on performance-based measures of physical function have been inconsistent. Adequately powered randomized trials are needed to de termine the long-term safety and efficacy of testosterone in imp...
Source: Reviews in Endocrine and Metabolic Disorders - November 10, 2022 Category: Endocrinology Source Type: research

Diagnosis of hypogonadism in ageing men
AbstractTo make the diagnosis of hypogonadism in an ageing man, in absence of rare organic cause often referred to as functional or late onset hypogonadism (LOH), he should present with a clinical syndrome suggestive of androgen deficiency and have consistently low serum testosterone (T) levels. This does not differ from the diagnosis of any other form of hypogonadism. Particular to LOH diagnostic are uncertainties surrounding this entity: signs and symptoms of androgen deficiency (including sexual symptoms) are nonspecific in older men; clinical significance of only moderately low T levels is uncertain; comorbidity plays ...
Source: Reviews in Endocrine and Metabolic Disorders - November 10, 2022 Category: Endocrinology Source Type: research