Impulse control disorders in hyperprolactinemic patients on dopamine agonist therapy
AbstractDopamine agonists (DAs) represent a mainstay of therapy for hyperprolactinemia and prolactinomas. The widespread use of DAs, including bromocriptine, cabergoline and (in some countries) quinagolide, has led to the emergence and recognition of impulse control disorders (ICDs) that may occur in association with DA therapy.Such ICDs include pathological gambling, compulsive shopping, hypersexuality and punding (the performance of repetitive tasks), among others. These manifestations can lead to substantial harms to patients and their families, if left undiagnosed and untreated. Several risk factors that may increase t...
Source: Reviews in Endocrine and Metabolic Disorders - September 20, 2022 Category: Endocrinology Source Type: research

The role of testosterone in male sexual function
In conclusion, it is our opinion that PDE5i along with lifestyle measures should be considered the first approach for treating ED even in subjects with milder T deficiency. When these interventions fail or are difficult to apply, TRT should be considered. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

The medicalization of testosterone: reinventing the elixir of life
AbstractThe pursuit of longevity, which during the Renaissance era was limited to longing for miraculous ways of rejuvenation, such as bathing in the fountain of youth, took a scientific turn in 1889 with the publication of Brown-Sequard ’s self-experiments with an extract of animal testes, which apparently improved his vitality, physical strength and cognition. This extract, marketed then as the"Elixir of Life", was sold for decades throughout Europe and North America. However, recent replication of Brown-Sequard ’s experiments demonstrated that such an extract only contains homeopathic concentrations of tes...
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

Variable phenotypes of individual and family monogenic cases with hyperinsulinism and diabetes: a systematic review
This study illustrates that the same genotype can give a biphasic phenotype in the same person or a reverse phenotype in the same family. Wider awareness of this association is necessary in pediatrics to establish annual monitoring of patients who have presented HH, and during maternity to screen diabetes and optimize genetic counseling and management of pregnancy, childbirth, and the newborn.PROSPERO registration: CRD42020178265. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

The role of testosterone in male sexual function
In conclusion, it is our opinion that PDE5i along with lifestyle measures should be considered the first approach for treating ED even in subjects with milder T deficiency. When these interventions fail or are difficult to apply, TRT should be considered. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

The medicalization of testosterone: reinventing the elixir of life
AbstractThe pursuit of longevity, which during the Renaissance era was limited to longing for miraculous ways of rejuvenation, such as bathing in the fountain of youth, took a scientific turn in 1889 with the publication of Brown-Sequard ’s self-experiments with an extract of animal testes, which apparently improved his vitality, physical strength and cognition. This extract, marketed then as the"Elixir of Life", was sold for decades throughout Europe and North America. However, recent replication of Brown-Sequard ’s experiments demonstrated that such an extract only contains homeopathic concentrations of tes...
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

Variable phenotypes of individual and family monogenic cases with hyperinsulinism and diabetes: a systematic review
This study illustrates that the same genotype can give a biphasic phenotype in the same person or a reverse phenotype in the same family. Wider awareness of this association is necessary in pediatrics to establish annual monitoring of patients who have presented HH, and during maternity to screen diabetes and optimize genetic counseling and management of pregnancy, childbirth, and the newborn.PROSPERO registration: CRD42020178265. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - August 23, 2022 Category: Endocrinology Source Type: research

Cognitive deficits in primary hyperparathyroidism – what we know and what we do not know: A narrative review
AbstractClassic symptoms of primary hyperparathyroidism (PHPT) are seen in approximately 20% of patients. While features such as kidney stones and skeletal disease are often highlighted as directly related to the disease, others can be even more prevalent. For example, cognitive dysfunction and reduced quality of life are common complaints in many patients, even among those who are classified as being asymptomatic. The pathophysiology of PHPT involves the impact of excess parathyroid hormone (PTH) on calcium metabolism. Referencing putative neurocognitive issues, many animal studies have illustrated the potential roles of ...
Source: Reviews in Endocrine and Metabolic Disorders - August 22, 2022 Category: Endocrinology Source Type: research

Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis
AbstractSpinal cord injury (SCI) can lead to dramatic physiological changes which can be a factor in developing secondary health conditions and might be reflected in biomarker changes in this elevated risk group. We focused specifically on the endocrine and inflammation profile differences between SCI and able-bodied individuals (ABI). Our aim was to determine the differences in inflammatory markers and endocrine profiles between SCI and ABI. We systematically searched 4 electronic databases for relevant studies. Human observational (cross-sectional, cohort, case –control) studies that compared biomarkers of interest bet...
Source: Reviews in Endocrine and Metabolic Disorders - August 18, 2022 Category: Endocrinology Source Type: research

Effect of resistance training on bioelectrical phase angle in older adults: a systematic review with Meta-analysis of randomized controlled trials
This study aimed to achieve a systematic review with meta-analysis on the impact of resistance training on bioelectrical proprieties in older adults.A literature review was done in four electronic databases up to 1 January 2022. The inclusion criteria were: (i) participants aged  ≥ 60 years; (ii) resistance training lasted ≥ 8 weeks; (iii) measurement of raw bioelectrical parameters in randomized controlled study designs.The outcomes of the trial had to be bioelectrical phase angle (PhA), resistance (R), and reactance (Xc). The methodological quality was assessed using the Rosendal scale.Overall, seven studies ...
Source: Reviews in Endocrine and Metabolic Disorders - August 3, 2022 Category: Endocrinology Source Type: research

Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies
AbstractEmotional eating is commonly defined as the tendency to (over)eat in response to emotion. Insofar as it involves the (over)consumption of high-calorie palatable foods, emotional eating is a maladaptive behavior that can lead to eating disorders, and ultimately to metabolic disorders and obesity. Emotional eating is associated with eating disorder subtypes and with abnormalities in emotion processing at a behavioral level. However, not enough is known about the neural pathways involved in both emotion processing and food intake. In this review, we provide an overview of recent neuroimaging studies, highlighting the ...
Source: Reviews in Endocrine and Metabolic Disorders - August 1, 2022 Category: Endocrinology Source Type: research