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Relationships between endogenous and exogenous testosterone and cardiovascular disease in men
AbstractIn this narrative review, we discuss the evidence about the controversy about the cardiovascular effects of endogenous and exogenous testosterone in men. Prospective cohort studies with follow-up of  ~5–15 years generally indicate no association or a possible inverse relationship between serum endogenous testosterone concentrations and composite major cardiovascular events, cardiovascular deaths and overall mortality. Pharmacoepidemiological studies of large databases generally show no ass ociation between testosterone therapy and incident major cardiovascular events, and some pharmacoepidemiological studies d...
Source: Reviews in Endocrine and Metabolic Disorders - October 11, 2022 Category: Endocrinology Source Type: research

Efficacy of radiofrequency and laser thermal ablation in solving thyroid nodule-related symptoms and cosmetic concerns. A systematic review and meta-analysis
AbstractSeveral studies have showed good/excellent results of thermal-ablation (TA) to reduce volume of benign thyroid nodule (TN). Nevertheless, no systematic review has reported information about clinical achievements with TA. Being the latter of high interest, this systematic review was undertaken to achieve high evidence about the efficacy of TA in reducing TN-related symptoms and cosmetic concerns. Radiofrequency (RFA) and laser (LA) therapies were considered. A comprehensive literature search of online databases was performed on January 2022 looking for studies reporting clinical results obtained by RFA or LA in term...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Vitamin D deficiency and cardiometabolic risk factors in adolescents: systematic review and meta-analysis
AbstractVitamin D deficiency is associated with an increase in the occurrence of cardiometabolic events, but the evidence of this relationship in adolescence is still limited. Thus, we analyzed the association between vitamin D deficiency and cardiometabolic risk factors in adolescents. Observational studies were searching in PubMed/Medline, Embase, Scopus, Web of Science, Science Direct, Lilacs, and Google Scholar database. Random effects models were used to summarize standardized mean differences for as a summary measure. The certainty of the evidence was verified using the Cochrane recommendations. A total of 7537 studi...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Posttranslational modifications in diabetes: Mechanisms and functions
AbstractAs one of the most widespread chronic diseases, diabetes and its accompanying complications affect approximately one tenth of individuals worldwide and represent a growing cause of morbidity and mortality. Accumulating evidence has proven that the process of diabetes is complex and interactive, involving various cellular responses and signaling cascades by posttranslational modifications (PTMs). Therefore, understanding the mechanisms and functions of PTMs in regulatory networks has fundamental importance for understanding the prediction, onset, diagnosis, progression, and treatment of diabetes. In this review, we ...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Diagnostic accuracy of bilateral inferior petrosal sinus sampling using desmopressin or corticotropic- releasing hormone in ACTH-dependent Cushing ’s syndrome: A systematic review and meta-analysis
The objective of this systematic review and meta-analysis was to estimate the diagnostic accuracy of BIPSS using DDAVP or CRH for the differential diagnosis of Cushing ’s syndrome (CS). A literature review was done in PubMed, Scopus, EMBASE, and google scholar databases to derive summary estimates of the overall diagnostic sensitivity and accuracy of BIPSS using DDAVP or CRH in Cushing’s syndrome. Pooled sensitivity, specificity, diagnostic odds ratio and summ ary receiver operating characteristic curves (SROC) for differential diagnosis of Cushing’s syndrome in the random-effects models, were computed. Overall, 11 d...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Metabolic actions of the growth hormone-insulin growth factor-1 axis and its interaction with the central nervous system
AbstractThe growth hormone/insulin growth factor-1 axis is a key endocrine system that exerts profound effects on metabolism by its actions on different peripheral tissues but also in the brain. Growth hormone together with insulin growth factor-1 perform metabolic adjustments, including regulation of food intake, energy expenditure, and glycemia. The dysregulation of this hepatic axis leads to different metabolic disorders including obesity, type 2 diabetes or liver disease. In this review, we discuss how the growth hormone/insulin growth factor-1 axis regulates metabolism and its interactions with the central nervous sys...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Interactions between nuclear receptors glucocorticoid receptor α and peroxisome proliferator–activated receptor α form a negative feedback loop
AbstractBoth nuclear receptors glucocorticoid receptor α (GRα) and peroxisome proliferator–activated receptor α (PPARα) are involved in energy and lipid metabolism, and possess anti-inflammation effects. Previous studies indicate that a regulatory loop may exist between them.In vivo andin vitro studies showed that glucocorticoids stimulate hepatic PPAR α expression via GRα at the transcriptional level. This stimulation of PPARα by GRα has physiological relevance and PPARα is involved in many glucocorticoid-induced pathophysiological processes, including gluconeogenesis and ketogenesis during fasting, insulin res...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Impulse control disorders in hyperprolactinemic patients on dopamine agonist therapy
AbstractDopamine agonists (DAs) represent a mainstay of therapy for hyperprolactinemia and prolactinomas. The widespread use of DAs, including bromocriptine, cabergoline and (in some countries) quinagolide, has led to the emergence and recognition of impulse control disorders (ICDs) that may occur in association with DA therapy.Such ICDs include pathological gambling, compulsive shopping, hypersexuality and punding (the performance of repetitive tasks), among others. These manifestations can lead to substantial harms to patients and their families, if left undiagnosed and untreated. Several risk factors that may increase t...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Patient-reported outcome measures for assessing health-related quality of life in people with type 2 diabetes: A systematic review
In conclusion, a large number of PROMs are available for people with type 2 diabetes, which intend to measure (aspects of) HRQOL. These PROMs measure a large variety of (sub)constructs, which are not all HRQOL constructs, with a small amount of PROMs not measuring HRQOL at all. There is a need for consensus on which aspects of HRQOL should be measured in people with type 2 diabetes and which PROMs to use in research and daily practice. PROSPERO: CRD42017071012. COMET database:http://www.comet-initiative.org/studies/details/956. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Ser/Thr phosphatases: One of the key regulators of insulin signaling
AbstractProtein phosphorylation is an important post-translational modification that regulates several cellular processes including insulin signaling. The evidences so far have already portrayed the importance of balanced actions of kinases and phosphatases in regulating the insulin signaling cascade. Therefore, elucidating the role of both kinases and phosphatases are equally important. Unfortunately, the role of phosphatases is less studied as compared to kinases. Since brain responds to insulin and insulin signaling is reported to be crucial for many neuronal processes, it is important to understand the role of neuronal...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Correction to: Chemotherapy in NEN: still has a role?
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Correction to: The role of transforming growth factor beta in thyroid autoimmunity: current knowledge and future perspectives
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2022 Category: Endocrinology Source Type: research

Sleep, testosterone and cortisol balance, and ageing men
AbstractSleep serves important biological functions, and influences health and longevity through endocrine and metabolic related systems. Sleep debt, circadian misalignment and sleep disruption from obstructive sleep apnea is widespread in modern society and accumulates with life because recovery sleep is not completely restorative. Accumulated disordered sleep throughout life impacts the ageing process and the development of age-related diseases. When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosteron...
Source: Reviews in Endocrine and Metabolic Disorders - September 24, 2022 Category: Endocrinology Source Type: research