Reviews in Endocrine and Metabolic Disorders This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mitochondrial epigenetic modifications and nuclear-mitochondrial communication: A new dimension towards understanding and attenuating the pathogenesis in women with PCOS
AbstractMitochondrial DNA (mtDNA) epigenetic modifications have recently gained attention in a plethora of complex diseases, including polycystic ovary syndrome (PCOS), a common cause of infertility in women of reproductive age. Herein we discussed mtDNA epigenetic modifications and their impact on nuclear-mitochondrial interactions in general and the latest advances indicating the role of mtDNA methylation in the pathophysiology of PCOS. We highlighted epigenetic changes in nuclear-related mitochondrial genes, including nuclear transcription factors that regulate mitochondrial function and may be involved in the developme...
Source: Reviews in Endocrine and Metabolic Disorders - January 27, 2023 Category: Endocrinology Source Type: research

Phase angle in assessment and monitoring treatment of individuals with respiratory disease
In conclusion PhA is a novel biomarker of morbidity and mortality in patients with severe respiratory diseases. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - January 25, 2023 Category: Endocrinology Source Type: research

Regulation of adipogenesis by exosomal milk miRNA
AbstractMilk is a rich source of miRNA packaged in exosomes. Evidence for the systemic uptake and tissue distribution of milk exosomes was reported in newborn and adult humans and animals. Breastfeeding in infants was associated with a reduced risk of obesity. Numerous adipogenesis-related miRNAs have been detected in human milk exosomes. It has been demonstrated that ingested exosomal milk miRNAs may alter gene expression in offspring to regulate their metabolism and growth. In humans, consumption of other species ’ milk, such as cows and goats, is continued through adulthood. Since miRNAs are conserved, the concern of ...
Source: Reviews in Endocrine and Metabolic Disorders - January 24, 2023 Category: Endocrinology Source Type: research

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy
AbstractPituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pitui...
Source: Reviews in Endocrine and Metabolic Disorders - January 20, 2023 Category: Endocrinology Source Type: research

The diagnosis and management of pheochromocytoma and paraganglioma during pregnancy
AbstractDiagnosis of pheochromocytoma or paraganglioma (PPGL) in pregnancy has been associated historically with high rates of materno-fetal morbidity and mortality. Recent evidence suggests outcomes are improved by recognition of PPGL before or during pregnancy and appropriate medical management with alpha-blockade. Whether antepartum surgery (before the third trimester) is required remains controversial and open to case-based merits. Women with PPGL in pregnancy are more commonly delivered by Caesarean section, although vaginal delivery appears to be safe in selected cases. At least some PPGLs express the luteinizing hor...
Source: Reviews in Endocrine and Metabolic Disorders - January 13, 2023 Category: Endocrinology Source Type: research

Adrenal disorders in pregnancy
AbstractProgress in our understanding of adrenal disorders affecting pregnant women has been hindered by three major hurdles: the phenotypical and biochemical overlap between pregnancy and adrenal pathology, the infrequent presentation of adrenal disorders during pregnancy, and the scarcity of human studies that include pregnant women. Pregnancy-specific adrenal hormone calibrations are lacking. Thus, the evaluation and management of adrenal disorders presenting during pregnancy are challenging. In this thematic issue, prominent experts in adrenal physiology and pathology have joined forces to offer a comprehensive collect...
Source: Reviews in Endocrine and Metabolic Disorders - January 2, 2023 Category: Endocrinology Source Type: research

The hallmarks of cancer … in pituitary tumors?
AbstractOver 20  years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation. This classical review, along with two revisions published in 2011 and 2022, has remain a classic of the oncology literature. Since many of the addressed biologi cal processes may apply to non-malignant tumorigenesis, we evaluated to what extent these hallmarks pertain to the development of pituitary adenomas.Some of the biological processes analyzed in this review include genome instability generated by somatic USP8 and GNAS mutations in Cushing ’s diseases and acrome...
Source: Reviews in Endocrine and Metabolic Disorders - December 31, 2022 Category: Endocrinology Source Type: research

Correction to: Phase angle (PhA) in overweight and obesity: evidence of applicability from diagnosis to weight changes in obesity treatment
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - December 26, 2022 Category: Endocrinology Source Type: research

Periconceptional biomarkers for maternal obesity: a systematic review
AbstractPericonceptional maternal obesity is linked to adverse maternal and neonatal outcomes. Identifying periconceptional biomarkers of pathways affected by maternal obesity can unravel pathophysiologic mechanisms and identify individuals at risk of adverse clinical outcomes. The literature was systematically reviewed to identify periconceptional biomarkers of the endocrine, inflammatory and one-carbon metabolic pathways influenced by maternal obesity. A search was conducted in Embase, Ovid Medline All, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases, complemented by manual sea...
Source: Reviews in Endocrine and Metabolic Disorders - December 15, 2022 Category: Endocrinology Source Type: research