Reviews in Endocrine and Metabolic Disorders This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Towards precision medicine in non-alcoholic fatty liver disease
AbstractNon-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and other features of the metabolic syndrome. Its more severe form (NASH, Non-Alcoholic Steatohepatitis) is becoming the leading aetiology of end-stage liver disease and hepatocellular carcinoma, and also contributes to cardiovascular disease, diabetes and extrahepatic malignancy. Management is currently limited to lifestyle modification and optimisation of the metabolic co-morbidities, with some of the drugs used for the latter also having s...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

Towards precision medicine in bariatric surgery prescription
AbstractObesity is a complex, multifactorial and chronic disease. Bariatric surgery is a safe and effective treatment intervention for obesity and obesity-related diseases. However, weight loss after surgery can be highly heterogeneous and is not entirely predictable, particularly in the long-term after intervention. In this review, we present and discuss the available data on patient-related and procedure-related factors that were previously appointed as putative predictors of bariatric surgery outcomes. In addition, we present a critical appraisal of the available evidence on which factors could be taken into account whe...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

Towards an adiposity-related disease framework for the diagnosis and management of obesities
AbstractObesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, ...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

Obesity phenotypes and cardiovascular risk: From pathophysiology to clinical management
AbstractObesity epidemic reached the dimensions of a real global health crisis with more than one billion people worldwide living with obesity. Multiple obesity-related mechanisms cause structural, functional, humoral, and hemodynamic alterations with cardiovascular (CV) deleterious effects. A correct assessment of the cardiovascular risk in people with obesity is critical for reducing mortality and preserving quality of life. The correct identification of the obesity status remains difficult as recent evidence suggest that different phenotypes of obesity exist, each one associated with different degrees of CV risk. Diagno...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

How to address weight regain after bariatric surgery in an individualized way
AbstractBariatric surgery is the most effective obesity treatment. As a chronic and progressive disease, weight loss response to surgery will vary individually. Thus, insufficient weight loss or regain can happen after surgery, but they lack a standard definition. There are different mechanisms underlying weight regain and/or insufficient weight loss, such as genetics, maladaptive eating behaviors, and the inadequate choice of index operations, among others. Patients with weight regain or insufficient weight loss should be submitted to an individualized and comprehensive evaluation by a multidisciplinary team. This may hel...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

Precision nutrition in the context of bariatric surgery
AbstractBariatric surgery (BS) is the most effective long-term treatment for severe obesity. This review summarizes the main nutritional deficiencies before and after BS, as well as current dietary and supplementation recommendations to avoid them. Likewise, we have reviewed all those aspects that in recent years have been shown to be related to postoperative weight loss (WL) and its subsequent maintenance, such as hormonal changes, dietary patterns, changes in food preference, adherence to recommendations and follow-up, genetic factors and microbiota, among others. Despite all the knowledge, nutritional deficiencies and w...
Source: Reviews in Endocrine and Metabolic Disorders - October 1, 2023 Category: Endocrinology Source Type: research

Does it work in childhood and adolescence? The predictive role of postoperative/preablative stimulated thyroglobulin levels in paediatric thyroid cancer. A systematic review of the literature
DiscussionptTg is a readily available and inexpensive parameter, bearing a strong prognostic power in identifying disease persistence, relapse, and the presence of metastases in children affected by DTC. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - September 25, 2023 Category: Endocrinology Source Type: research

Correction: Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta ‑analysis
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - September 25, 2023 Category: Endocrinology Source Type: research

Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
AbstractDue to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC) remain challenging. Molecular imaging provides valuable tools for early disease detection, monitoring treatment response, and guiding personalized therapies. By enabling the visualization of molecular and cellular processes, these techniques contribute to a deeper understanding of disease mechanisms and the development of more effective clinical interventions. Different nuclear imaging techniques have been studied for assessing MTC, and among them, PET/CT utilizing mult...
Source: Reviews in Endocrine and Metabolic Disorders - September 16, 2023 Category: Endocrinology Source Type: research

Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs go on stage
AbstractThe incidence of childhood obesity and metabolic syndrome has grown notably in the last years, becoming major public health burdens in developed countries. Nowadays, oxidative stress is well-recognized to be closely associated with the onset and progression of several obesity-related complications within the framework of a complex crosstalk involving other intertwined pathogenic events, such as inflammation, insulin disturbances, and dyslipidemia. Thus, understanding the molecular basis behind these oxidative dysregulations could provide new approaches for the diagnosis, prevention, and treatment of childhood obesi...
Source: Reviews in Endocrine and Metabolic Disorders - September 6, 2023 Category: Endocrinology Source Type: research

Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis
AbstractBariatric surgery is associated with a postoperative reduction of 25(OH) vitamin D levels (25(OH)D) and with skeletal complications. Currently, guidelines for 25(OH)D assessment and vitamin D supplementation in bariatric patients, pre- and post-surgery, are still lacking. The aim of this work is to analyse systematically the published experience on 25(OH)D status and vitamin D supplementation, pre- and post-surgery, and to propose, on this basis, recommendations for management. Preoperatively, 18 studies including 2,869 patients were evaluated. Prevalence of vitamin D insufficiency as defined by 25(OH)D < ...
Source: Reviews in Endocrine and Metabolic Disorders - September 4, 2023 Category: Endocrinology Source Type: research