Circulating Immunological Biomarkers: Prognosis of Pancreatic Cancer Patients Reflected by the Immune System
To date, little advances have been made toward new and more effective therapies for pancreatic ductal adenocarcinoma (PDAC). Discovery of prognostic and predictive biomarkers is needed to stratify patients for available treatments and to elucidate how new therapies could be developed. Recent studies have made clear that the immune system is not only affected in the microenvironment of the primary tumor and it is also systemically disrupted in PDAC patients. Under normal circumstances, the immune system is in perfect balance with both proinflammatory and anti-inflammatory components present. In this review, we focus on circ...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Metastasis Suppressor Genes in Pancreatic Cancer: An Update
Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), has for long remained a deadly form of cancer characterized by high mortality rates resulting from metastasis to multiple organs. Several factors, including the late manifestation of the disease, partly amplified by lack of efficient screening methods, have hampered the drive to design an effective therapeutic strategy to treat this deadly cancer. Understanding the biology of PDAC progression and identifying critical genes regulating these processes are essential to overcome the barriers toward effective treatment. Metastasis suppressor genes have been ...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Early Detection of Pancreatic Cancer: Applying Artificial Intelligence to Electronic Health Records
The potential of artificial intelligence (AI) applied to clinical data from electronic health records (EHRs) to improve early detection for pancreatic and other cancers remains underexplored. The Kenner Family Research Fund, in collaboration with the Cancer Biomarker Research Group at the National Cancer Institute, organized the workshop entitled: “Early Detection of Pancreatic Cancer: Opportunities and Challenges in Utilizing Electronic Health Records (EHR)” in March 2021. The workshop included a select group of panelists with expertise in pancreatic cancer, EHR data mining, and AI-based modeling. This review article ...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Pancreatic Pain—Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the r...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Conference Report Source Type: research
2021 American Pancreatic Association Presidential Address: Together Again
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Editorial Source Type: research
Histological Differentiation Is a Pivotal Prognostic Factor Associated With the Pattern of Recurrence Following Resection of Pancreatic Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Pacinian Corpuscles in Pancreas: Possible Clinical Implications
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Ammann Pain Type and the Clinical Course of Painful Chronic Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Delay in Pancreatic Endoscopic Ultrasound During the COVID-19 Pandemic in a Pancreas/Tertiary Referral Center
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Proceedings of the Japan Pancreas Society, 2020, Suizo, the Journal of the Japan Pancreas Society, Volume 35, 2020, Naohiro Sata, MD, PhD, Editor-in-Chief
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Abstracts Source Type: research
Rapid Progression After 177Lu-DOTATATE in Patients With Neuroendocrine Tumors
Peptide receptor radionuclide therapy (PRRT) is a treatment option for somatostatin receptor–positive, unresectable or metastatic neuroendocrine tumors (NETs). Despite high disease control rates seen with PRRT, a subset of the NET population seems to have a short progression-free interval. We hypothesize that patients with NETs with rapid progression post-PRRT may have mixed low- and high-grade cell populations, and PRRT treats the lower-grade component, allowing the more aggressive high-grade component to progress. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Case Report Source Type: research
Use of Chromogranin A for Monitoring Patients With Pancreatic Neuroendocrine Neoplasms
Conclusions
We concluded that serum CgA levels are associated with disease status and treatment response and may thus provide a helpful biomarker for the monitoring and clinical management of patients with pNENs. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Immunoglobulin G4-Related Disease Responder Index Correlates With the Risk of 1-Year Relapse in Type 1 Autoimmune Pancreatitis
This study evaluated the IgG4-RD RI as prognostic factor of 1-year disease relapse.
Methods
Patients diagnosed with type 1 AIP between January 2012 and December 2016, with available magnetic resonance imaging and IgG4 dosage, were enrolled. Immunoglobulin G4-RD RI was calculated at baseline (time 0), and at 3 to 6 and 12 to 18 months after the end of steroid therapy (time 1 and time 2, respectively).
Results
Thirty-three patients were included in the study. Immunoglobulin G4-RD RI was 8.9 (standard deviation [SD], 3.8) at time 0, 2.4 (SD, 3.1) at time 1 (P (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Individualized Prediction of Acute Pancreatitis Recurrence Using a Nomogram
The objective of this study was to develop and validate a model, based on the blood biochemical (BBC) indexes, to predict the recurrence of acute pancreatitis patients.
Methods
We retrospectively enrolled 923 acute pancreatitis patients (586 in the primary cohort and 337 in the validation cohort) from January 2014 to December 2016. Aiming for an extreme imbalance between recurrent acute pancreatitis (RAP) and non-RAP patients (about 1:4), we designed BBC index selection using least absolute shrinkage and selection operator regression, along with an ensemble-learning strategy to obtain a BBC signature. Multivariable ...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Validation of the Modified Determinant-Based Classification for Patients With Acute Pancreatitis in Intensive Care Medicine
Objectives
To validate the Modified Determinant-Based Classification (MDBC) system, and compare it with the Revised Atlanta Classification (RAC) and the Determinant-Based Classification (DBC).
Methods
Prospective observational research was conducted in 35 international intensive care units, on patients with acute pancreatitis, and at least 1 organ failure (OF). Patient classification according to the MDBC was as follows: group 1 (transient OF, without local complications [LCs]), group 2 (transient OF and LC), group 3 (persistent OF, without LC), and group 4 (persistent OF and LC).
Results
A total of 316 p...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
