The Quick Sepsis-Related Organ Failure Assessment Score Is Prognostic of Pancreatitis Severity in Patients With Alcohol-Induced Pancreatitis
Objectives
The aim of this study was to determine if the quick Sepsis-Related Organ Failure Assessment (qSOFA) score assessed at and 48 hours after admission is prognostic for alcohol-induced acute pancreatitis (AAP) severity.
Methods
This is a retrospective cohort review study of 161 patients admitted to a single academic hospital in Houston, TX, with the diagnosis of AAP. Receiver operator characteristics analysis and logistic regression were used to assess the diagnostic accuracy and prognostic ability of the qSOFA score.
Results
A qSOFA score of 2 or higher at and 48 hours after admission had a specif...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Pharmacological Ascorbate Enhances Chemotherapies in Pancreatic Ductal Adenocarcinoma
Conclusions
The addition of P-AscH− to standard of care chemotherapy has the potential to be an effective adjuvant for PDAC treatment. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Telomere Attrition in Intraductal Papillary Mucinous Neoplasms of the Pancreas Associated With Carcinogenesis and Aging
Objectives
It is challenging to preoperatively distinguish malignant and benign forms of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. The aims of this study were to investigate whether telomere length is associated with pathological grade of IPMNs and age and to clarify the utility of telomere length as a marker to identify malignant IPMNs.
Methods
Pancreas tissue was obtained from 28 patients after resection. We measured the telomere lengths of tumor cells in IPMNs and normal duct cells by quantitative fluorescence in situ hybridization. The association of normalized telomere-centromere rat...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Perioperative Coagulation Changes in Total Pancreatectomy and Islet Autotransplantation
Conclusions
Apart from the immediate period after islet cell and heparin infusion, patients undergoing TPIAT are generally hypercoagulable leading to a high rate of thrombotic complications. Portal vein thrombosis development had minimal association with systemic derangements in coagulation as it is likely driven by localized inflammation at the time of islet cell infusion. This study may provide the groundwork for future studies to identify improvements in thrombotic complications. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Prophylaxis of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis Using Temporary Pancreatic Stents Versus Rectal Nonsteroidal Anti-inflammatory Drugs: A Randomized Controlled Trial
Conclusions
Rectal administration of 50 mg of diclofenac may become a first-line therapy for PEP prophylaxis in our country. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Patient Preferences for Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma
Conclusions
Among a national cohort of PDAC survivors and caregivers, the majority preferred SF for resectable PDAC, whereas NT was preferred when the resectability of a tumor was in question. The impact of NT on quantity and quality of life, as well as the likelihood of achieving surgical resection, was most highly valued by participants. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Decreased Intestinal Microbiota Diversity Is Associated With Increased Gastrointestinal Symptoms in Patients With Chronic Pancreatitis
Objectives
Chronic pancreatitis (CP) is characterized by abdominal pain, recurrent hospitalizations, frequent exposure to antibiotics, nutritional deficiencies, and chronic opioid use. Data describing the gut microbial community structure of patients with CP is limited. We aimed to compare gut microbiota of a group of patients with severe CP being considered for total pancreatectomy with islet autotransplantation (TPIAT) with those of healthy controls and to associate these differences with severity of clinical symptoms.
Methods
We collected stool from healthy donors (n = 14) and patients with CP (n = 20) underg...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Preoperative Predictive Features of Invasive Carcinoma Among Intraductal Papillary Mucinous Neoplasm of the Pancreas
Conclusions
Enhancing MN greater than or equal to 13 mm, obstructive jaundice, and an abrupt change in the PD caliber were predictive factors for invasive carcinoma. Systematic lymph node dissection may be omitted when a high-risk patient has none of these factors. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
An Examination of Donor Factors That Impact the Results of the Glucagon Stimulation Test as an Assessment of the Pancreatic Graft Endocrine Function
We examined the associations between delta C-peptide as pancreatic graft endocrine function and donor background factors.
Methods
Sixty-five cases of pancreatic transplantation from brain-dead donors, which were performed in our facility, were enrolled in this study. Enrolled recipients underwent a glucagon stimulation test within 1 to 3 months after transplantation to evaluate the pancreatic graft endocrine function with delta C-peptide to compare donor background factors.
Results
The following factors were associated with significant deterioration of the delta C-peptide: age of 50 years or greater, death fr...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Helping Patients Understand Pancreatic Cancer Using Animated Pancreas Patient Education With Visual Formats of Learning
Conclusions
Pancreatic cancer patient education using APP's visual formats of learning demonstrated a wide reach and had a significant impact on improved understanding among patients, families, and caregivers. Continued efforts should be made to provide patient resources that address health literacy, better quality of life and improved health outcomes in pancreatic cancer. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
The Change in the Fibrosis-4 Index for the Assessment of Liver Fibrosis After Pancreaticoduodenectomy
Objectives
Nonalcoholic fatty liver is a complication of pancreaticoduodenectomy (PD); however, liver fibrosis after PD is not well documented. Therefore, we estimated the hepatic fibrotic index of nonalcoholic fatty liver after PD.
Methods
We retrospectively examined the electronic medical records of patients who had underwent PD and had computed tomography (CT) records preoperatively and 6 months postoperatively between 2011 and 2019 at the Shiga University of Medical Science Hospital.
Results
Overall, 115 patients were enrolled. After 6 months from PD, body mass index significantly decreased from 21.90...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm
Objectives
Some intraductal papillary mucinous neoplasms (IPMNs) have malignant potential and can become pancreatic cancer. The mechanism behind the malignant progression of IPMN remains unknown. We aimed to identify the risk factors and interactions between backgrounds for IPMN.
Methods
We retrospectively enrolled 980 patients of pancreatic cancer or suspected IPMN (sIPMN) who underwent endoscopic ultrasound or retrograde cholangiopancreatography. We classified them into pancreatic cancer, high-risk sIPMN, and low-risk sIPMN, and investigated the risk factors for high-risk sIPMN.
Results
Smoking habits (...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Organoids: A Promising Preclinical Model for Pancreatic Cancer Research
Pancreatic cancer is one of the most lethal cancer types, estimated to become the second leading cause of cancer-related deaths in the United States in 2030. The use of 3-dimensional culture systems has greatly expanded over the past few years, providing a valuable tool for the study of pancreatic cancer. In this review, we highlight some of the preclinical in vitro and in vivo models used in pancreatic cancer research, each with its own advantages and disadvantages, and focus on one of the recently used 3-dimensional culture models: organoids. Organoids are multicellular units derived from tissue samples and embedded with...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Review Source Type: research
Rationale and Development of a Data Coordinating Center to Support the Type 1 Diabetes in Acute Pancreatitis Consortium
We describe how the T1DAPC DCC supports the consortium via its experience and expertise in project management, administration, financial management, regulatory compliance, scientific coordination, data management, research computing, and biostatistics and in facilitating scientific publications. The DCC's matrix management system has been extremely effective in managing all of its responsibilities. The first 16 months in the life of the T1DAPC have been dedicated to the development of its first protocol, titled Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM), addressing the institutional review board and ...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium
This article highlights the challenges in recruitment and retention strategies in AP studies and reviews available resources to create opportunities to address them. We describe the multifaceted approach used by the Recruitment and Retention Committee of the Type 1 Diabetes in Acute Pancreatitis Consortium, which builds upon earlier experiences to develop a recruitment and retention plan for the DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) study. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
