Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium
Differences in methods for biospecimen collection, processing, and storage can yield considerable variability and error. Therefore, best practices for standard operating procedures are critical for successful discovery, development, and validation of disease biomarkers. Here, we describe standard operating procedures developed for biospecimen collection during the DREAM (Diabetes RElated to Acute pancreatitis and its Mechanisms) Study within the Type 1 Diabetes in Acute Pancreatitis Consortium. Notably, these protocols were developed using an integrative process based on prior consortium experience and with input from work...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium
This core component of the Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM) study will examine the hypothesis that advanced magnetic resonance imaging (MRI) techniques can reflect underlying pathophysiologic changes and provide imaging biomarkers that predict diabetes mellitus (DM) after acute pancreatitis (AP). A subset of participants in the DREAM study will enroll and undergo serial MRI examinations using a specific research protocol. The aim of the study is to differentiate at-risk individuals from those who remain euglycemic by identifying parenchymal features after AP. Performing longitudinal MRI wil...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium
This article describes one objective of the DREAM study: to determine the immunologic mechanisms of DM after AP, including the contribution of β-cell autoimmunity. This component of the study will assess the presence of islet autoimmunity, as well as the magnitude and kinetics of the innate and adaptive immune response at enrollment and during longitudinal follow-up after 1 or more episodes of AP. Finally, DREAM will evaluate the relationship between immune features, DM development, and pancreatitis etiology and severity. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium
Conclusions
The DREAM study will comprehensively assess the metabolic and endocrine changes that precede and lead to the development of DM after AP. (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium
Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the e...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality
Acute pancreatitis (AP), resulting from inflammation of the pancreas, accounts for more than 300,000 US hospital discharges per year. Although glucose intolerance has been known as a complication of severe AP, this effect was thought to be transient. Recently, cohort studies and meta-analysis of 24 published studies of 1100 patients who survived one or more episodes of AP revealed that 30% to 40% of patients developed diabetes or impaired glucose tolerance within 3 to 4 years of even a single episode of AP. The National Institute of Diabetes and Digestive and Kidney Diseases funded the Type 1 Diabetes in Acute Pancreatitis...
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: T1DAPC Reports Source Type: research
Identification of Anaerobic Organism Infection in a Patient With Emphysematous Pancreatitis Based on Metagenomic Next-Generation Sequencing: A Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Diffuse Pancreatic Serous Cystic Neoplasm: A Rare Cause of Pancreatic Insufficiency
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Bifurcated Main Pancreatic Duct With Pancreatic Stone Impaction Leading to Acute Cholangitis: A Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Agenesis of Dorsal Pancreas With Chronic Calcific Pancreatitis: The Head Without a Body
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Unusual Case of Delayed Rupture of Pancreatic Neuroendocrine Tumor After Endoscopic Ultrasound and Biopsy
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Plasma Osteopontin Levels as an Early Predictor of Mortality in Acute Pancreatitis: A Preliminary Study
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Validation of Serum MicroRNAs-19a, -24, and -29a as Potential Markers to Differentiate Pancreatic Cancer–Associated Diabetes From Type 2 Diabetes Mellitus
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Neurofibromatosis Type 1: A Rare Predisposition for Gastrinomas and Other Neuroendocrine Tumors
We present the case of a 52-year-old lady who presented with recurrent peptic ulceration and diarrhea. Serum gastrin levels were elevated and magnetic resonance imaging demonstrated the presence of a pancreatic lesion with multiple liver metastases. The lesion was moderately fludeoxyglucose avid on positron emission tomography-computed tomography. Endoscopic ultrasonography-guided sampling revealed the presence of synaptophysin positive neuroendocrine cells with positive gastrin immunostaining. A conservative approach was adopted, and the patient's symptoms improved on proton pump inhibitors. Zollinger-Ellison syndrome is ...
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Case Report Source Type: research
Machine Learning for Computed Tomography Radiomics: Prediction of Tumor-Infiltrating Lymphocytes in Patients With Pancreatic Ductal Adenocarcinoma
Conclusions
The XGBoost-based model could predict PDAC TILs and may facilitate clinical decision making for immune therapy. (Source: Pancreas)
Source: Pancreas - May 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
