The Pancreatitis Activity Scoring System Predicts Clinical Outcomes in Patients With Infected Pancreatic Necrosis
Objectives
The Pancreatitis Activity Scoring System (PASS) is an objective tool validated in acute pancreatitis but not in infected pancreatic necrosis (IPN). Our aim was to evaluate the role of PASS in IPN.
Methods
We performed a retrospective cohort study of IPN patients admitted to the University of California, San Francisco from January 2011 to March 2019. Daily PASS scores were calculated for each patient. Receiver operator characteristic analysis was used to define the optimal cutoff PASS score to predict outcomes. The primary and secondary outcomes were 72 hours postintervention multiorgan failure (MOF) a...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report From the Prospective Observational Study of TPIAT Cohort
Conclusions
Active smoking and alcohol abuse history were associated with a diagnosis of anxiety and depression, respectively; however, at the time of TPIAT, symptom scores suggested that they were being addressed. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Evidence for Roux-en-Y Pancreatic Duct Drainage Versus Standard Anastomosis in Pancreatic Transplantation
We examined the effect of enteric drainage method on transplant outcomes.
Methods
Data were obtained from the UK transplant registry on 2172 consecutive pancreatic transplants. Early graft loss was the primary endpoint. Secondary endpoints included return to theater, length of inpatient stay, readmission with pancreatitis, graft survival, and patient survival.
Results
There was no protective effect of ReY drainage (early graft loss, 4.6% vs 3.1%, P = 0.30; hazard ratio, 0.98; 95% confidence interval, 0.63–1.52; P = 0.91). There was a significant association between ReY and return to theater, reflecting eith...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Gastrointestinal Bleed After Total Pancreatectomy With Islet Autotransplant
Conclusions
Twelve percent of patients developed a GIB after TPIAT. One third of those had an undefined etiology despite endoscopy. The need for intervention was high (30%). (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Impact of Postoperative Glycemic Control on Postoperative Morbidity in Patients Undergoing Open Pancreaticoduodenectomy
Conclusions
Early hyperglycemia (>180 mg/dL) is associated with a higher risk of surgical site infections while late hyperglycemia is associated with a higher risk of fistulas. Intensive glucose control ( (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Incidence, Treatment, and Survival of Synchronous Peritoneal Metastases in Pancreatic Cancer: Update of a Nationwide Cohort
Objective
The aim of the study was to gain insight in the incidence, treatment, and survival of patients with synchronous pancreatic peritoneal metastases.
Methods
All patients diagnosed with pancreatic cancer between 2008 and 2018 in the Netherlands Cancer Registry were evaluated. The patients were subcategorized as (1) synchronous peritoneal metastases, (2) synchronous systemic metastases, and (3) no metastases.
Results
In total, 25,334 patients with pancreatic cancer were included. Among them, 3524 (14%) presented with synchronous peritoneal metastases, 10,659 (42%) with systemic metastases, and 11,151...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Transcatheter Arterial Infusion Combined With Radioactive Particles in the Treatment of Advanced Body/Tail Pancreatic Cancer: A Retrospective Cohort Study
Objectives
This retrospective cohort study investigated the efficacy of routine intravenous chemotherapy (the control group), transcatheter arterial infusion (TAI) chemotherapy, and TAI combined with radioactive particles as therapeutic methods for advanced body/tail pancreatic cancer by assessing the short-term and overall survival rates.
Methods
We screened our prospective database for patients with advanced body/tail pancreatic cancer, which tumor deemed unresectable, and no other confirmed malignant tumors, patients were assigned into 3 groups according to their treatment: routine intravenous chemotherapy, T...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Rapid On-Site Evaluation by Endosonographer of Endoscopic Ultrasound Fine-Needle Aspiration of Solid Pancreatic Lesions: A Randomized Controlled Trial
Objectives
Rapid on-site evaluation (ROSE) by cytopathologists during endoscopic ultrasound–fine-needle aspiration (EUS-FNA) of solid pancreatic lesions (SPLs) improves adequacy and diagnostic accuracy while reducing the number of needle passes. We evaluated the usefulness of ROSE performed by the endosonographer.
Methods
Patients with an SPL were randomly assigned to EUS-FNA with ROSE or non-ROSE. Procedure duration, number of needle passes, specimen adequacy, and adverse event rates were compared.
Results
Sixty-five patients were enrolled (33 in the ROSE vs 32 in the non-ROSE group). Both groups were ...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Threshold Analysis of the Cost-effectiveness of Endoscopic Ultrasound in Patients at High Risk for Pancreatic Ductal Adenocarcinoma
Conclusions
Pancreatic cancer screening can be cost-effective through index EUS, particularly for those individuals at high-lifetime risk of cancer. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Survival and Predictive Factors of Chemotherapy With FOLFIRINOX as First-Line Therapy in Metastatic Pancreatic Cancer: A Retrospective Multicentric Analysis
Conclusions
In patients with metastatic pancreatic adenocarcinoma treated with FOLFIRINOX in first line, dose modifications at the onset of adverse effects and early use of granulocyte-colony stimulating factor seem to be associated with a better survival. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Survival Outcomes Based on Sequence of Therapy Using FOLFIRINOX and Nab-Paclitaxel + Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma
Conclusions
In this analysis of real-world data, 1L FOLFIRINOX was associated with increased OS in propensity analysis. For patients who received both FOLFIRINOX and nab-p/gem, median OS was similar regardless of sequence. (Source: Pancreas)
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Endoscopic Versus Laparoscopic Treatment for Pancreatic Pseudocysts: A Systematic Review and Meta-analysis
Objective
The aim of the study was to evaluate the efficacy and safety of endoscopic treatment for pancreatic pseudocysts (PPCs) compared with laparoscopic treatment.
Methods
The Embase, Medline, Cochrane Library, Web of Science databases, China National Knowledge Infrastructure Chinese citation database, and WANFANG database were systematically searched to identify all comparative trials investigating endoscopic versus laparoscopic treatment for PPC. The main outcome measures included treatment success rate, adverse events, recurrence rate, operation time, intraoperative blood loss, and hospital stay.
Result...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Emerging Treatment Strategies in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer death in well-developed countries. Therapeutic advances in PDAC to date have been modest. Recent progress to understand the molecular landscape of the disease has opened new treatment opportunities for a small subset of patients, frequently those with KRAS wild-type disease. Novel treatment strategies in PDAC include, among others, the use of nanotechnology and metabolic reprogramming. In addition, new strategies are being investigated, which are designed to overcome the resistance to checkpoint inhibitors, targeting DNA repair pathways including m...
Source: Pancreas - July 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Comment on “Diagnostic Value of Serum Amylase Levels Indicating Computed Tomography–Defined Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis”
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
DNA Damage Repair Defects and Survival Outcomes for Patients With Resected Pancreatic Ductal Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - May 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
