Resection Prolongs Overall Survival for Nonmetastatic Midgut Small Bowel Neuroendocrine Tumors: A National Cancer Data Base Study
This study aimed to understand if resection (RS) for nonmetastatic small bowel neuroendocrine tumors (SBNETs) prolongs 5-year overall survival.
Methods
Patients from National Cancer Data Base with primary histologically confirmed SBNETs from 2007 to 2016 were included. Patients younger than 18 years, with the disease in the duodenum/Meckel diverticulum or metastatic disease were excluded. We assessed 5-year survival rates using Kaplan-Meier curves and multivariate Cox proportional hazards regression after RS, nonresection surgical management (NRS), or no resection (NR). Multivariate models were adjusted with age, se...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Auditing Management of Acute Pancreatitis Using Comprehensive Quality Indicators
Objectives
Recently, 40 comprehensive quality indicators in various management domains were created. The aim was to determine if these indicators could be used to audit the management of acute pancreatitis.
Methods
A retrospective study of consecutive patients admitted with acute pancreatitis in 2018 was conducted. Adherence rates with the individual quality indicators were calculated and compared between services.
Results
A total of 320 patients were included in this study. Twenty-eight of the 40 quality indicators (70%) could be used to audit management retrospectively. The medical service was found to ...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Clinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors: 10 Years of Experience From a Single Center
Objectives
Gastorenteropancreatic neuroendocrine (GEP-NET) tumors are the second most common tumors of the gastrointestinal tract. We aimed to investigate the clinicopathological features and factors affecting the prognosis of patients with GEP-NET.
Methods
Clinicopathological features of 158 patients were evaluated, including tumor location, TNM stage and grade, pathological features, presence of lymph nodes and distant metastases at the time of diagnosis, maximum tumor diameter and treatment details. Also, follow-up information was analyzed to discover possible prognostic factors.
Results
The most commo...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Celiac Plexus Neurolysis Is Associated With Decreased Survival in Patients With Pancreatic Cancer: A Propensity Score Analysis
Objective
The aim of this study was to investigate survival in patients who received celiac plexus neurolysis (CPN) compared with patients who received opioids.
Methods
The Surveillance, Epidemiology and End Results–Medicare database was used to identify patients older than 65 years diagnosed with pancreatic cancer between 2007 and 2015. We used claims data to identify patients with a history of CPN and opioid use within 1 year of diagnosis, and other demographic, clinical, and treatment variables. Kaplan-Meier analyses and inverse propensity-weighted adjusted Cox proportional hazard ratios were used to evalua...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Sarcopenia: Prognostic Value for Unresectable Pancreatic Ductal Adenocarcinoma Patients Treated With Gemcitabine Plus Nab-Paclitaxel
Conclusions
Sarcopenia diagnosed by L3-SMI is a prognostic factor in elderly patients who receive GnP for unresectable PDAC. However, GnP exhibits a certain efficacy in sarcopenia and nonsarcopenia patients. (Source: Pancreas)
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Outpatient Pain Management in Children With Chronic Pancreatitis: A Scoping Systematic Review
Conclusions
No therapy had sufficient high-quality studies to warrant untempered, evidence-based support for use in children with CP. Multicenter studies are needed to identify pain management “best practices.” (Source: Pancreas)
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Development of a Score for Predicting Severe Acute Pancreatitis at Admission
Conclusions
The ASAP score demonstrates remarkable predictive accuracy in distinguishing severe forms of acute pancreatitis. (Source: Pancreas)
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
The Role of Estrogen Signaling in Cellular Iron Metabolism in Pancreatic β Cells
Several lines of evidence suggest that estrogen (17-β estradiol; E2) protects against diabetes mellitus and plays important roles in pancreatic β-cell survival and function. Mounting clinical and experimental evidence also suggest that E2 modulates cellular iron metabolism by regulating the expression of several iron regulatory genes, including hepcidin (HAMP), hypoxia-inducible factor 1-α, ferroportin (SLC40A1), and lipocalin (LCN2). However, whether E2 regulates cellular iron metabolism in pancreatic β cells and whether the antidiabetic effects of E2 can be, at least partially, attributed to its role in iron metaboli...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Reviews Source Type: research
Current Evidence in the Management of Premalignant Cystic Lesions of the Pancreas in Patients Undergoing Liver Transplantation
Incidental premalignant pancreatic cystic lesions (pPCLs) are increasingly being detected in patients undergoing orthotopic liver transplantation (OLT). The impact of chronic immunosuppression upon pPCLs may elevate risk of progression to pancreatic cancer. This systematic review assesses prevalence, outcome, and management of pPCLs in patients undergoing OLT. Systematic literature searches were performed in accordance with Cochrane review guidelines. Data on 658 patients were identified from 13 articles. Median age was 59 years with a prevalence of 6.2%. Most studies focused on branch-duct intraductal papillary mucinous n...
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Reviews Source Type: research
Predicting Clinical Severity in Acute Pancreatitis: Addressing the Admission Dilemma
No abstract available (Source: Pancreas)
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: Editorial Source Type: research
Memorial Tribute to Paul D. Webster, III, MD
No abstract available (Source: Pancreas)
Source: Pancreas - February 1, 2022 Category: Gastroenterology Tags: In Memoriam Source Type: research
A Randomized, Double-Blinded, Placebo-Controlled Trial of Simvastatin to Prevent Recurrent Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Association of BRCA Mutations and Pancreatic Cancer: Review of Literature and Meta-analysis
No abstract available (Source: Pancreas)
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Spontaneous Peritoneal Rupture of a Large Pancreatic Pseudocyst in a Critically Ill Patient: Nonoperative Management and a Review of Literature
No abstract available (Source: Pancreas)
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Are Fungi Becoming the Most Common Organisms in Primary Infected Pancreatic Necrosis?
No abstract available (Source: Pancreas)
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
