Human Recombinant Arginase I [HuArgI(Co)-PEG5000]–Induced Arginine Depletion Inhibits Pancreatic Cancer Cell Migration and Invasion Through Autophagy
Conclusions
Altogether, these findings uncover the mechanism of action of [HuArgI(Co)-PEG5000] and highlight the promising and selective anticancer potential for arginine depletion in the treatment of pancreatic cancer cells. (Source: Pancreas)
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Predictors of the Failure of Noninvasive Ventilation in Patients With Acute Respiratory Failure Caused by Severe Acute Pancreatitis: A Prospective Observational Study
Conclusions
One of 4 SAP patients experience NIV failure. Age, sex, disease severity, level of inflammation, and vital signs can be used to predict NIV failure. (Source: Pancreas)
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
A Comparative Study of Endoscopic Ultrasonography and Histopathology Images for the Diagnosis of Early Chronic Pancreatitis
Conclusions
Endoscopic ultrasonography findings for ECP, according to Japan's 2019 revised criteria, lobularity, and the hyperechoic margin of the pancreatic duct may highly correspond to the pathological findings of chronic inflammation. (Source: Pancreas)
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Pancreatic Neuroendocrine Neoplasias in Multiple Endocrine Neoplasia Type 1 Are Predominantly Located in the Dorsal Anlage: An Endoscopic Ultrasound Study
Conclusions
Our study indicates that the vast majority of pNENs in MEN1 is located in the dorsal anlage, whereas the ventral anlage of the pancreas seems to be to a large extend spared from pNENs. Implications for new surgical strategies might be considered. (Source: Pancreas)
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Adjuvant Chemotherapy Is Not Guided by Pathologic Treatment Effect After Neoadjuvant Chemotherapy in Pancreatic Cancer
Conclusions
Despite 73.1% of patients with partial or poor response to neoadjuvant chemotherapy, only 46.7% received a different adjuvant regimen. Medical oncologists infrequently considered treatment effect when choosing adjuvant therapy. Pathologic response to neoadjuvant chemotherapy should be considered when selecting adjuvant chemotherapy. (Source: Pancreas)
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Effect of Laparoscopic Pancreaticoduodenectomy in Elderly People: A Meta-analysis
Pancreaticoduodenectomy is considered to be the most complicated operation in abdominal surgery. The purpose of this study was to evaluate the safety and efficacy of laparoscopic pancreaticoduodenectomy (LPD) in elderly patients. We searched PubMed, Embase, and Cochrane Library databases for relevant studies that were published before June 2020. Seven cohort studies were eligible with 3200 patients. The result of meta-analysis showed that, for the elderly, severe complications, clinical pancreas fistula, and delayed gastric emptying in the LPD group were significantly lower than those in the open pancreaticoduodenectomy (O...
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Quality of Life Instruments and Trajectories After Pancreatic Cancer Resection: A Systematic Review
This systematic review aimed to investigate the instruments available to measure quality of life (QOL) after pancreatic cancer surgery and to describe short- and long-term QOL outcomes. A comprehensive literature search was completed using PubMed, Embase, and Medline from inception to March 2019. Studies investigating QOL outcomes in patients undergoing pancreatic cancer surgery who were 18 years or older were included. The main outcomes of interest were QOL instruments and short (≤6 months) and long term (>6 months) QOL outcomes. The overarching domains of physical, psychosocial, overall QOL, symptoms, and other were us...
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Peripheral Blood Cell Variables Related to Systemic Inflammation in Patients With Unresectable or Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis
Systemic inflammatory response (SIR) plays a central role in the prognosis of unresectable or metastatic pancreatic ductal adenocarcinoma (mPDAC), and many SIR-related peripheral blood cell (PBC)-derived variables have been proposed as prognostic factors. The study aims to perform a systematic review and, for the more studied PBC-derived variables, a meta-analysis. A systematic review from 2000 to 2020 on 2 databases by predefined criteria was performed for PBC-derived variables in patients with mPDAC receiving chemotherapy in relation with overall survival. Eligible studies were selected by inclusion criteria, and only th...
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
The Role of Inherited Pathogenic CDKN2A Variants in Susceptibility to Pancreatic Cancer
CDKN2A is cell cycle negative regulator, and the role of CDKN2A in the development of pancreatic ductal adenocarcinoma, which continues to be a lethal cancer, is well-established. Somatic loss of CDKN2A is considered one of the major drivers of pancreatic tumorigenesis. CDKN2A gene is one of the pancreatic cancer susceptibility gene; in addition to melanoma, pathogenic germline CDKN2A variants have been identified in up to 3.3% patients with pancreatic ductal adenocarcinoma depending on family history of disease. Carriers of a known pathogenic germline CDKN2A variant have up to a 12.3-fold increased risk of developing panc...
Source: Pancreas - September 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Inosine 5′-Monophosphate Dehydrogenase Cytoophidia Neighbor Insulin Granules in Pancreatic β Cells
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
High Levels of Activation in Patients With Surgical Diseases of the Pancreas
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Acrodermatitis Enteropathica–Like Dermatosis After Whipple Procedure
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Author Index for American Pancreatic Association Abstracts
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Author Index Source Type: research
Abstracts of Papers Submitted to the 52nd Meeting of the American Pancreatic Association, November 3–6, 2021, Miami Beach, Florida
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Abstracts Source Type: research
Minutes of the Business Meeting of the American Pancreatic Association, Sunday, November 1, 2020, Virtual Meeting
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Minutes Source Type: research
