Pancreatitis-Associated Genes and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis
Conclusion Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC. (Source: Pancreas)
Source: Pancreas - September 11, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatic Cancer–Associated Depression: A Case Report and Review of the Literature
The prevalence of major depressive disorder (MDD) in pancreatic cancer (PC) has been reported up to 7 times higher than the general population. Despite repeated studies that show worse quality of life, survival outcomes, and treatment compliance in cancer patients with depression, baseline antidepressant use ranges from 15% to 27%. A meta-analysis of 6 prospective trials specific to PC estimates that 43% of patients with PC experience depression after diagnosis. This is especially alarming in patients with PC, who may experience a prodrome of symptoms including depression and loss of drive. In fact, this prodrome of sympto...
Source: Pancreas - September 11, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Role of Radiological Imaging in the Diagnosis and Characterization of Pancreatic Cystic Lesions: A Systematic Review
The evidence on the ability of radiological tests to predict a specific diagnosis and also their aptitude in identifying pathological markers indicative of malignancy in cystic lesions of the pancreas remains inconclusive. We conducted a systematic review on MEDLINE for the use of computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT (PET/CT) in the diagnosis and characterization of these cysts. The accuracy of CT scan for reaching a specific diagnosis was 39% to 61.4%, whereas its accuracy for differentiating benign from malignant lesions was 61.9% to 80%. Magnetic resonance imaging sho...
Source: Pancreas - September 11, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Harnessing Analytic Morphomics for Early Detection of Pancreatic Cancer
No abstract available (Source: Pancreas)
Source: Pancreas - September 11, 2018 Category: Gastroenterology Tags: Editorial Source Type: research

Cardiac Toxicity in a Patient Receiving Peptide Receptor Radionuclide Therapy
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

β-Catenin Expression in Glucagon-Producing α Cells of Human Fetal Pancreatic Islets Suggests Wnt Signaling-Dependent Development
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Anti–PD-1 Drug (Nivolumab) May Induce Acute and Life-Threatening Pancreatitis in Lung Cancer Patient: A Case Report
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Retrospective Analysis of Factors Associated With Venous Thromboembolism Among Pancreatic Cancer Patients: A Single Institution Experience
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Adjuvant Treatment in Potentially Curable Pancreatic Cancer: Need to Include Tumor Location in the Equation?
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Glucose Intolerance After Pancreatectomy Was Associated With Preoperative Hemoglobin A1c, Insulin Resistance, and Histological Pancreatic Fatty Infiltration
No abstract available (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Research of Acellular Pancreatic Bioscaffold as a Natural 3-Dimensional Platform In Vitro
Objective The aim of the study was to investigate the biochemical and functional properties of a rat acellular pancreatic bioscaffolds (APBs). Methods Fresh pancreata from 10 rats were soaked and perfused through portal veins using Easy-Load Digital Drive peristaltic pumps. The histological structure, extracellular matrix composition, and the DNA content of the APBs were evaluated. Biocompatibility studies had also been performed. The proliferation and differentiation of AR42J pancreatic acinar cells were assessed. Results The pancreatic tissue became translucent after decellularization. There were no visible vascu...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Analysis of Prognostic Factors in Pancreatic Metastases: A Multicenter Retrospective Analysis
Objectives Pancreatic metastases (PMs) account for 1% to 2% of pancreatic tumors, and their prognostic significance is poorly defined. We evaluated the incidence and clinical characteristics of primary tumors and defined prognostic factors. Methods This retrospective study of 39 Japanese tertiary referral hospitals (January 2005 to August 2015) analyzed patient and tumor characteristics and survival time. Kaplan-Meier analysis and Cox proportional hazards models were applied to evaluate overall survival and prognostic factors, respectively. Results We enrolled 159 patients with a pathologic diagnosis of PM. The mos...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Early Predictors of Abdominal Hemorrhage Among Critically Ill Patients With Pancreatitis: A Prospective Cohort Study
Conclusions Abdominal hemorrhages were common among critically ill patients with pancreatitis. These early predictors may be of use in detecting patients at risk of developing them. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas: A Nationwide Multicenter Study in Japan
Conclusions The proportion of male cases was higher than that in previous studies, and there were statistically significant differences in the onset age and tumor diameter between male and female patients. Therefore, women seemed to have an early occurrence of SPNs, suggesting a difference in the developmental stage between men and women. Images and pathological findings of SPNs varied according to tumor size. Our findings indicated that SPN patients have excellent survival after margin-negative surgical resection. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Exocrine Pancreatic Insufficiency and Malnutrition in Chronic Pancreatitis: Identification, Treatment, and Consequences
Conclusions There is a high prevalence of fat-soluble vitamin deficiencies, osteopathy, and malnutrition in CP patients, which is underestimated due to a lack of effective diagnosis and suboptimal therapies for EPI. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Incidence and Predictors of 30-Day Readmission Among Patients Hospitalized for Chronic Pancreatitis
Conclusions Hospital readmissions for CP are frequent and pose a significant healthcare burden. Performing cholecystectomy, endoscopic retrograde cholangiopancreatography, or pancreatectomy during index admission was associated with reduced odds of readmission. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Survival and Prognostic Factors in Patients With Solid Pseudopapillary Neoplasms of the Pancreas
Conclusions Patients with SPN who undergo resection have an excellent survival at 5 years. Surgery should be considered in all patients with this diagnosis. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Cholecystectomy During Index Admission for Acute Biliary Pancreatitis Lowers 30-Day Readmission Rates
Objectives Few studies have evaluated national readmission rates after acute pancreatitis (AP) in the United States. We sought to evaluate modifiable factors impacting 30-day readmissions after AP hospitalizations. Methods We used the Nationwide Readmission Database (2013) involving all adults with a primary discharge diagnosis of AP. Multivariable logistic regression models assessed independent predictors for specific outcomes. Results Among 180,480 patients with AP index admissions, 41,094 (23%) had biliary AP, of which 10.5% were readmitted within 30 days. The 30-day readmission rate for patients who underwent s...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Utility of Endoscopic Ultrasound-Guided Biopsy for Next-Generation Sequencing of Pancreatic Exocrine Malignancies
Conclusions Endoscopic US FNA and FNB provided similar NGS adequacy rates. Metastatic lesions accessible by percutaneous biopsy may be preferable to EUS FNB/A of primary lesions for obtaining tissue for NGS. All biopsies, including EUS FNB, were more likely to be successful using larger-gauge needles. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Patient and Procedural Factors Associated With Increased Islet Cell Yield in Total Pancreatectomy With Islet Autotransplantation
Conclusions Factors that diminish a successful islet cell harvest during TPIAT include the presence of infected islets, an elevated preoperative glycated hemoglobin, and the presence of pancreatic duct stones. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Safety and Feasibility of Integrating Yttrium-90 Radioembolization With Capecitabine-Temozolomide for Grade 2 Liver-Dominant Metastatic Neuroendocrine Tumors
Conclusions CapTemY90 is feasible and safe for grade 2 NETs. Toxicities were additive. Oncologic outcomes suggest synergy. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Comparison of the Survival Outcomes of Pancreatic Cancer and Intraductal Papillary Mucinous Neoplasms
Conclusions Stage-matched analysis did not show a significant survival difference between invasive IPMN and PDAC patients, and T3 or higher was an independent prognostic factor for invasive IPMN. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis
Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study
Conclusions Although pancreatic cancer mortality remains high, our study highlights baseline characteristics, treatment, biological factors, and ethnicity that are associated with long-term survival. These findings may serve as a springboard for further investigation. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Pancreatic Pseudocysts and Parenchymal Necrosis in Patients With Autoimmune Pancreatitis: A Systematic Review
Conclusions Pseudocysts in AIP are rare. Pancreatic pseudocyst can present in variable number, size, and location. Small PC resolved with steroids. Large PC had poor response to steroids requiring invasive interventions. Necrosis in AIP has not been reported. (Source: Pancreas)
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Acute Pancreatitis in Chronic Dialysis Patients
The annual incidence of acute pancreatitis (AP) ranges from 4.9 to 73.4 cases per 100,000 worldwide. Patients with end-stage renal disease on dialysis have an increased risk for developing AP compared with patients without renal disease. In addition to the general population risk factors, there are factors related to renal insufficiency and dialysis process that might predispose to AP in this population. Clinical features and diagnosis are the same as those in patients without renal failure; however, amylase and lipase levels should be interpreted cautiously as they might be falsely elevated in renal failure. In this artic...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Pancreatic Cancer–Induced Cachexia and Relevant Mouse Models
Pancreatic cancer is the third leading cause of cancer death in the United States, with projections that it will become the second leading cause by the year 2030. It carries a dismal prognosis with a 5-year overall survival rate of less than 9% and is associated with numerous comorbidities, the most notable being cachexia. Defined as the loss of muscle mass not reversible by conventional nutritional support, cachexia is seen in over 85% of pancreatic cancer patients and contributes significantly to mortality, where nearly 30% of pancreatic cancer deaths are due to cachexia rather than tumor burden. Therefore, there is an u...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts
Pancreatic cancer requires many genetic mutations. Combinations of underlying germline variants and environmental factors may increase the risk of cancer and accelerate the oncogenic process. We systematically reviewed, annotated, and classified previously reported pancreatic cancer–associated germline variants in established risk genes. Variants were scored using multiple criteria and binned by evidence for pathogenicity, then annotated with published functional studies and associated biological systems/pathways. Twenty-two previously identified pancreatic cancer risk genes and 337 germline variants were identified ...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Preexisting Diabetes Elevates Risk of Local and Systemic Complications in Acute Pancreatitis: Systematic Review and Meta-analysis
The prevalence of diabetes mellitus (DM) and acute pancreatitis (AP) increases continuously, therefore, to understand the effects of preexisting diabetes on AP is crucially needed. Here, we performed a systematic review and meta-analysis in which AP patients including DM and non-DM groups were sorted. Several outcome parameters were analyzed, and the odds ratio (OR) and standardized mean difference with 95% confidence intervals (CIs) were calculated. We found 1417 articles, of which 9 articles involving 354,880 patients were analyzed. More complications were seen in diabetic patients than in non-DM patients (OR, 1.553 [95...
Source: Pancreas - August 17, 2018 Category: Gastroenterology Tags: Reviews Source Type: research

Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Clinical Features and Prognosis of Patients With the Bone Metastasis of Pancreatic Cancer: A Single-Institutional Cohort Study
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Five Cases of Interstitial Pneumonitis Due to Gemcitabine and Nab-Paclitaxel Combination Treatment in Pancreatic Cancer Patients
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Successful Orthotopic Heart Transplantation in a Patient With Chronic Pancreatitis: Selective Medical and Surgical Considerations
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Disease Course Differences in Acute Pancreatitis Based on Etiology Using the Pancreatitis Activity Scoring System
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Acute Pancreatitis History Carries Higher Risk in Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Lesions
No abstract available (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

A Novel Approach for Therapeutic Delivery to the Rodent Pancreas Via Its Arterial Blood Supply
Conclusions Our study demonstrates a novel technique that can be used to selectively deliver therapeutics directly to the rat pancreas in a safe manner with full recovery of the animal. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Spexin Modulates Functions of Rat Endocrine Pancreatic Cells
Conclusions The effects of spexin on insulin secretion in vitro and in vivo and also on cells viability and proliferation confirm that this peptide may be strongly involved in the pathogenesis of diabetes or its recovery. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Cerulein-Induced Acute Pancreatitis Affects Sphingomyelin Signaling Pathway in Rats
Conclusions Because it is known that sphingosine-1-phosphate and some of its analogs could have a protective role against AP complications, our findings may contribute to elaboration of new therapeutic strategies in the management of this severe medical condition. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure
Conclusions Our data demonstrate that emodin plays a critical role in ameliorating AP, possibly by down-regulating autophagic protein levels. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Melatonin Attenuates Endoplasmic Reticulum Stress in Acute Pancreatitis
Conclusions These findings suggest that melatonin protects AR42J cells and Sprague-Dawley rats against AP-associated injury, probably through downregulation of IRE1α-mediated JNK/NF-κB pathways. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Adverse Events and Reinterventions Following Pancreatic Endoscopic Sphincterotomy
Conclusions The likelihood of reintervention after PES is high, particularly when the primary indication is suspected sphincter pathology such as idiopathic recurrent acute pancreatitis. Further prospective studies are needed to clarify if and when this maneuver confers significant benefit to patients. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

A Clinical Model for the Early Diagnosis of Acute Pancreatitis in the Emergency Department
Conclusions In emergency department patients with lipase elevated to 3 times the upper limit of normal or greater, this model helps identify AP risk before imaging. Prospective validation studies are needed to confirm diagnostic accuracy. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Spatial Distribution of Pancreatic Stones in Chronic Pancreatitis
Conclusions Compared with idiopathic CP, alcoholic CP patients were prone to more pancreatic stones that distribute more uniformly. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Systemic Depletion of Nerve Growth Factor Inhibits Disease Progression in a Genetically Engineered Model of Pancreatic Ductal Adenocarcinoma
Conclusions Anti-NGF treatment beginning at 4 weeks may increase inflammation and negatively impact disease. Treatment starting at 8 weeks (after disease onset), however, reduces neural inflammation, neural invasion, and metastasis. These data indicate that NGF impacts PDAC progression and metastasis in a temporally dependent manner. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Association Between Hepatitis B Infection and Pancreatic Cancer: A Population-Based Analysis in the United States
Conclusions This study concluded up to a 24% increased likelihood of pancreatic cancer among the HepB patients. Blacks showed greater odds of pancreatic cancer and related mortality. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Plasma Neurokinin A Levels Predict Survival in Well-Differentiated Neuroendocrine Tumors of the Small Bowel
Objectives Elevated neurokinin A (NKA) levels are associated with poor prognosis in patients with small bowel neuroendocrine tumors. We hypothesized that patients with NKA levels that remain elevated despite treatment with surgical cytoreduction have a poor prognosis. Methods Patients diagnosed with small bowel neuroendocrine tumors who underwent surgical cytoreduction at our institution were identified. Demographics, histopathologic characteristics, and biochemical data were collected. Patients were grouped by the trend of their NKA levels (group 1, continuously normal; group 2, transiently elevated but normalized af...
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Association Between Opioid Use and Survival Time in Patients With Unresectable Pancreatic Cancer: 10 Years of Clinical Experience
This study aimed to determine a correlation between prescribed opioid doses and survival time in patients with unresectable pancreatic cancer. Methods This retrospective observational cohort study in a tertiary care institution reviewed the medical records of patients diagnosed with unresectable pancreatic cancer and treated over a 10-year period. Results We screened 1152 patients with unresectable pancreatic cancer, and 566 were eligible for inclusion in this study. There was a statistically significant negative correlation between initial opioid dose and survival time from initial opioid dose (correlation coefficie...
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Pathologic Evaluation of Surgical Margins in Pancreatic Cancer Specimens Using Color Coding With Tissue Marking Dyes
Objectives Processing of pancreatoduodenectomy specimens is not standardized; the clinical impact of pathologic surgical margins remains controversial. We used the color-coding method using tissue-marking dyes to evaluate margin status of resected specimens to assess its association with postoperative recurrence. Methods We developed a unified processing approach to assess pancreatoduodenectomy specimens. Five surgical margins of resected pancreatic specimens were marked with 5 colors. Microscopic resection margin distance (RMD) from margin closest to the tumor was evaluated for each surgical margin. Forty patients as...
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma
Conclusion The CONUT score had an independent association with survival in patients with PDAC after pancreatectomy and was not associated with recurrence or postoperative complications. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research

Adverse Oncologic Impact of New-Onset Diabetes Mellitus on Recurrence in Resected Pancreatic Ductal Adenocarcinoma: A Comparison With Long-standing and Non–Diabetes Mellitus Patients
Conclusions Pancreatic ductal adenocarcinoma with new-onset DM has worse oncologic outcomes than non-DM or long-standing DM. These results suggest that new-onset DM represents aggressive tumor biology, especially in the early stage of PDAC. (Source: Pancreas)
Source: Pancreas - July 10, 2018 Category: Gastroenterology Tags: Original Articles Source Type: research