A Phase II Study of Ziv-Aflibercept in Patients With Advanced Extrapancreatic Neuroendocrine Tumors
Conclusions
Although the progression free survival is similar to other VEGF inhibitors in NET, toxicity may preclude further investigation. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Well-Differentiated Grade 3 Neuroendocrine Tumors: Characteristics, Treatments, and Outcomes From a Population-Based Study
Conclusions
Capecitabine-temozolomide and somatostatin analogs were associated with clinically meaningful benefit, and use of local therapies provided benefits in selected patients. Multidisciplinary discussion is essential to optimize individual outcomes in this heterogeneous population. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Fluid Resuscitation With Lactated Ringer's Solution Versus Normal Saline in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Trials
Conclusions
Our findings are able to assist clinicians in the navigation of the proper choice of fluid in patients with acute pancreatitis. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
The Use of Vasopressors During Deceased Donor Pancreas Procurement Decreases the Risk of Pancreas Transplant Graft Failure
The objective of this study was to identify the effect of various vasopressors on pancreas graft failure and patient survival.
Methods
A retrospective analysis of the United Network for Organ Sharing database was performed between 2000 and 2019. Patient and graft survival rates were analyzed up to 5 years posttransplant.
Results
The data included 17,348 pancreas transplant recipients: 12,857 simultaneous pancreas-kidney, 1440 pancreas transplant alone, and 3051 pancreas-after-kidney transplant recipients. Use of dopamine during deceased donor procurement increased graft failure by 18% (hazard ratio [HR], 1.18...
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Emodin Alleviates Sodium Taurocholate–Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway
Conclusions
Emodin attenuates STC-induced pancreatic ductal cell injury possibly by inhibiting S100A9/VNN1-mediated ROS release. This finding provides evidence for the future development of emodin as a therapeutic agent. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Association Between Family History and Risk of Pancreatic Cancer in Patients With BRCA1 and BRCA2 Pathogenic Variants
Conclusions
Our results do not support using family history to determine eligibility for pancreatic cancer screening. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Salivary Biomarker Evaluation of Chronic Pancreatitis Patients Reveals Alterations in Human Proteins, Cytokines, Prostaglandin E2 Levels, and Bacterial Diversity
Conclusions
Collectively, our studies identify a range of putative CP biomarkers and alterations in human saliva requiring further validation. The biomarker discovery approaches we used might lead to identification of biomarkers useful for CP diagnosis and monitoring. (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
Clinical Trials in Pancreatitis: Opportunities and Challenges in the Design and Conduct of Patient-Focused Clinical Trials in Recurrent Acute and Chronic Pancreatitis: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Recurrent acute pancreatitis and chronic pancreatitis represent high morbidity diseases, which are frequently associated with chronic abdominal pain, pancreatic insufficiencies, and reduced quality of life. Currently, there are no therapies to reverse or delay disease progression, and clinical trials are needed to investigate potential interventions that would address this important gap. This conference report provides details regarding information shared during a National Institute of Diabetes and Digestive and Kidney Diseases–sponsored workshop on Clinical Trials in Pancreatitis that sought to clearly delineate the cur...
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Conference Report Source Type: research
2022 American Pancreatic Association Presidential Address: Resilience
No abstract available (Source: Pancreas)
Source: Pancreas - August 1, 2022 Category: Gastroenterology Tags: Editorial Source Type: research
A Rare Case of Non–Small Cell Lung Metastases Mimicking Primary Pancreatic Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Genetic Alterations of Both MEN1/ATRX and TP53/RB1 in Pancreatic Neuroendocrine Neoplasms
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Extranodal Rosai-Dorfman Disease Involving the Pancreas: A Case Report and Literature Review
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Remdesivir-Induced Pancreatitis in a Patient With Coronavirus Disease 2019
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Proceedings of the Japan Pancreas Society, 2021, Suizo, the Journal of the Japan Pancreas Society, Volume 36, 2021, Naohiro Sata, MD, PhD, Editor-in-Chief
No abstract available (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Abstracts Source Type: research
Pancreatic Heterotopia in the Small Bowel: A Case Report and Literature Review
We report the case of a 66-year-old man who presented with ileus and jejunal PH diagnosed using single-balloon enteroscopy. Reviewing 178 cases of small intestinal PH in the literature showed that (1) PH mostly occurred at the duodenum (61.8%), followed by the jejunum (22.5%) and ileum (14.6%); (2) patients with ileal PH were younger (mean, 40.7 vs 54.6 years; P (Source: Pancreas)
Source: Pancreas - July 1, 2022 Category: Gastroenterology Tags: Case Report Source Type: research
