Provider Differences in Monitoring and Management of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis
This study evaluates whether provider type impacts EPI monitoring and management in CP.
Methods
Fecal elastase 1 (FE-1) testing and pancreatic enzyme replacement therapy (PERT) utilization were retrospectively compared between primary care providers (PCPs), gastroenterologists and pancreas specialists using pairwise comparisons. Multivariate analysis was conducted to study the association between adequate PERT and age, sex, race, insurance status, provider type, and etiology.
Results
Among 256 patients, FE-1 was measured in 115 (44.9%) and of 143 (55.9%) patients who received PERT, 100 (69.9%) received adequa...
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Original Articles Source Type: research
The Effects of NLRP3 Inflammasome Inhibition in Experimental Acute Pancreatitis: A Systematic Review and Meta-Analysis
Acute pancreatitis (AP) is an inflammatory disease, and NLRP3 inflammasome activation is involved in the pathogenesis of AP. Previous research showed that inhibition of NLRP3 inflammasome may exert protective effects on animal models of AP and reduces disease severity. The aim of this systematic review and meta-analysis is to evaluate the effects of drug treatment of NLRP3 inflammasome on the outcomes of experimental AP. PubMed, Embase, Medline, and Web of Science databases were searched for relevant articles without language restrictions. The main outcomes for this study included local pancreatic injury, the incidence of ...
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Reviews Source Type: research
Multidisciplinary Care for Adults With Chronic Pancreatitis: Incorporating Psychological Therapies to Optimize Outcomes
Chronic pancreatitis (CP) is associated with a high disease burden, extensive negative impact on quality of life, increased rates of depression and anxiety, and significant health care utilization and expenditures. Pain is a hallmark feature of CP, present in up to 90% of patients with this condition, and can lead to high rates of disability, hospitalization, and opioid medication use. Current perspectives on the management of CP have evolved to advocate a multidisciplinary approach which offers new pathways for helping patients manage symptoms. Psychologists play an important role in a multidisciplinary team effort by app...
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Reviews Source Type: research
The American Pancreatic Association 52nd Annual Meeting: The Vay Liang and Frisca Go Award for Lifetime Achievement and the Distinguished Service Award
No abstract available (Source: Pancreas)
Source: Pancreas - January 1, 2022 Category: Gastroenterology Tags: Conference Report Source Type: research
Comment on Effects of Prophylactic Antibiotics on Length of Stay and Total Costs for Pediatric Acute Pancreatitis: A Nationwide Database Study in Japan
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Clinical Characteristics of Patients With Pancreas Divisum: A 9-Year Retrospective Cohort Study
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Pancreatitis as the Leading Manifestation of Granulomatosis With Polyangiitis: Case Report and Review of the Literature
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
A Case of Rosai-Dorfman Disease Mimicking Immunoglobulin G4–Related Autoimmune Pancreatitis
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Transdiaphragmatic Pancreatic Fistulas: A Case Series of Rare Presentations
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Assessing the Prognostic Validity of the American Joint Committee on Cancer Staging Classification for Midgut Neuroendocrine Tumors
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Adult Proinsulinomatosis Associated With a MAFA Germline Mutation as a Rare Cause of Recurrent Hypoglycemia
We report the case of a 48-year-old female patient with recurrent hypoglycemia caused by benign proinsulin-secreting pancreatic neuroendocrine neoplasias (pNENs) with no history of multiple endocrine neoplasia type 1. Initial workup revealed elevated serum proinsulin levels and a positive fasting test. Magnetic resonance imaging and endosonography visualized 2 pNENs in the pancreatic body and tail that were treated by robotic-assisted enucleation. After initial biochemical cure, the patient's hypoglycemia recurred 3 months after surgery. Imaging showed a new lesion in the pancreatic body, so that now a spleen-preserving su...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Case Report Source Type: research
Genetic Analysis of Pediatric Pancreatoblastoma: A Case Report
Pediatric pancreatoblastoma (PBL) is a rare disease, and the treatment of which is diverse. The molecular alteration in pancreatoblastoma is not very clear. A 7-year-old female who presented with intermittent abdominal pain, anorexia, and abdominal mass was admitted in our hospital. Pancreaticoduodenectomy, cholecystectomy, and retroperitoneal lymph node dissection were conducted. Immunohistochemistry results after surgery showed creatine kinase +, clusters differentiation 56 −, clusters differentiation 99 +, carcinoembryonic antigen −, periodic acid-Schiff +, B- catenin +, Ki-67 + 70%, progesterone receptor +, neuron-...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Case Report Source Type: research
Hypophosphatemia Is More Common and Is Prognostic of Poorer Outcomes in Severe Alcoholic Pancreatitis
Objectives
The aim of this study was to determine if hypophosphatemia is more common in patients with severe alcohol-induced acute pancreatitis (AAP).
Methods
This is a retrospective, single institution, cohort study that analyzed 147 patients admitted to the hospital for AAP. Multivariate logistic regression was used to determine if hypophosphatemia would be related to clinical outcomes of disease severity.
Results
Hypophosphatemia was more common in patients with severe AAP at admission; in addition, all patients with severe AAP (100%) eventually developed hypophosphatemia during admission, relative to ...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Phase II Trial of Bevacizumab Monotherapy in Pancreatic Neuroendocrine Tumors
Conclusions
Bevacizumab demonstrated promising antitumor activity in progressive PNETs comparable to standard targeted therapy. Although this study failed to reject the null hypothesis (RR, 10%), bevacizumab seems a reasonable monotherapy and a potential component of combination therapies given clinical activity and low rates of adverse events. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Targeting of Smad7 in Mesenchymal Cells Does Not Exacerbate Fibrosis During Experimental Chronic Pancreatitis
Conclusions
There was no clear evidence that the lack of Smad7 in pancreatic stellate cells plays a major role in experimental pancreatitis, at least in the mouse model investigated here. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
