Facility Type Affects Treatment Outcomes for Patients With Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms of the Pancreas
Objective
Academic centers report better outcomes for pancreatic ductal adenocarcinoma. We hypothesized that treatment outcomes for mucinous cysts differ according to institution type.
Methods
Using the National Cancer Data Base, we analyzed data on patients with mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs).
Results
Of 3278 identified patients, 2622 (80%) had IPMNs and 656 (20%) had MCNs. While most academic/research programs (ARCPs, 84.9%) treated more than 10 patients/year, this was true for only 59% of integrated network cancer programs, 37.3% of comprehensive c...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Surgical Intervention Strategies of Necrotizing Pancreatitis With Abdominal Compartment Syndrome
Conclusions
The combination of multiple drainage tube placement, feeding jejunostomy, and ileostomy at the same time were effective surgical intervention strategies for NP patients with ACS, which brought a lower mortality rate. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
A Classification Algorithm for Types of Diabetes in Chronic Pancreatitis Using Epidemiological Characteristics: Outcome of a Longitudinal Cohort Study
Conclusions
The described algorithm based on epidemiological characteristics can help to classify types of DM in patients with CP. Diabetes mellitus type 3c is associated with longer duration of CP and more severe CP sequelae. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Identification of 2 Chinese Primary Pancreatic Ductal Adenocarcinoma Cancer Cell Lines and Their Phenotypes
Conclusions
Two new Chinese PC cell lines were established, both of which were characterized and confirmed with high tumorigenicity. They may serve as useful tools for pathogenesis research when evaluating new treatment strategies in Asian patients. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
The 3-Dimensional-Computed Tomography Texture Is Useful to Predict Pancreatic Neuroendocrine Tumor Grading
Conclusions
Computed tomography radiomics signature can be useful in preoperative workup. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Role of Resection of the Primary in Metastatic Well-Differentiated Neuroendocrine Tumors
Objective
Resection of the primary (RP) in metastatic neuroendocrine tumor (NET) is controversial. The aim was to evaluate survival outcomes for RP in metastatic NET patients.
Methods
Data were obtained from US hospitals at the National Cancer Database between 2004 and 2014. χ2, analysis of variance tests, univariate, and multivariate cox proportional hazards models were evaluated. Kaplan-Meier curves and log-rank tests conducted to compare the survival difference of patient characteristics.
Results
A total of 2361 patients were identified. The mean age was 62.1 years (standard deviation, 13 years), male...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Pancreatogenic Diabetes, 2 Onset Forms and Lack of Metabolic Syndrome Components Differentiate It From Type 2 Diabetes
Objectives
We compared pancreatogenic (DM3c) and type 2 diabetes mellitus.
Methods
We compared age-, sex-, and diabetes mellitus duration–matched DM3c cases (n = 142) and type 2 diabetes mellitus (n = 142). Pancreatogenic diabetes was considered when it appeared after the diagnosis of pancreatitis or after pancreatic surgery.
Results
Pancreatogenic diabetes presented lower body mass index (BMI) [odds ratio (OR), 1.2; 95% confidence interval (CI), 1.13–1.28; P (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Magnetic Resonance Imaging–Based Radiomics Models to Predict Early Extrapancreatic Necrosis in Acute Pancreatitis
Conclusions
The MRI-based radiomics models of both the extrapancreatic collections and the pancreatic parenchyma had excellent predictive performance for early EXPN. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Rituximab as Maintenance Therapy in Type 1 Autoimmune Pancreatitis: An Italian Experience
Conclusions
Rituximab seems be safe and effective for maintenance therapy of type 1 AIP during the first year after completing RTX infusion. However, the probability of disease relapse is high within 1 and 3 years from the last infusion. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Outcomes of Endoscopic Management of Sterile Walled-Off Pancreatic Necrosis: A Systematic Review
Conclusions
Although endoscopic management of sterile pancreatic necrosis has a high rate of treatment success, there is a relatively high rate of adverse events, bleeding being the most common. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis: Pharmacological Activities and Mechanisms
Acute pancreatitis (AP) is a common clinical gastrointestinal disorder with a high mortality rate for severe AP and lacks effective clinical treatment, which leads to considerable comorbidity and financial burden. Traditional Chinese medicine (TCM) has had the unique advantage of treating AP for a long time in China. Clinically, TCM formulas such as Da-cheng-qi decoction, Chai-qin-cheng-qi decoction, Qing-yi decoction, Da-chai-hu decoction, and Da-huang-fu-zi decoction are widely administrated to AP patients. All of these TCM formulas can improve gastrointestinal function, regulate the inflammatory response, and enhance im...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
Molecular Alterations in Solid Pseudopapillary Neoplasm of the Pancreas: The Achilles Heel in Conquering Pancreatic Tumorigenesis
This article provides an in-depth review into the molecular pathways that contribute to the pathogenesis of solid pseudopapillary neoplasms. It also discusses the implications of existing molecular pathways toward tumor aggressiveness and recurrence potential. (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
MicroRNAs in Pancreatic Cancer and Chemoresistance
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading malignancies affecting human health, largely because of the development of resistance to chemotherapy/radiotherapy. There are many mechanisms that mediate the development of drug resistance, such as the transport of antineoplastic agents into cells, shifts in energy metabolism and environment, antineoplastic agent-induced DNA damage, and genetic mutations. MicroRNAs are short, noncoding RNAs that are 20 to 24 nucleotides in length and serve several biological functions. They bind to the 3′-untranslated regions of target genes and induce target degradation or t...
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
The American Pancreatic Association 51st Annual Meeting: The Vay Liang and Frisca Go Award for Lifetime Achievement and the Distinguished Service Award
No abstract available (Source: Pancreas)
Source: Pancreas - November 1, 2021 Category: Gastroenterology Tags: Conference Report Source Type: research
Irreversible Electroporation: A Novel Treatment Modality in Locally Advanced and Unresectable Pancreatic Adenocarcinoma
No abstract available (Source: Pancreas)
Source: Pancreas - October 1, 2021 Category: Gastroenterology Tags: Letters to the Editor Source Type: research
