Xanthogranulomatous Pancreatitis Accompanied by Xanthogranulomatous Cholecystitis: A Case Report and Literature Review
Xanthogranulomatous pancreatitis (XGP) is extremely rare, with only 31 cases reported in the English literature to date. We reviewed previously reported 17 articles about XGP and report an additional case of XGP. This is the first case of XGP with xanthogranulomatous cholecystitis accompanied by intraductal papillary mucinous carcinoma (IPMC) in an 80-year-old woman. She was referred to our hospital with jaundice and general malaise and was found to have a cystic mass at the pancreatic head and a solid mass at the pancreatic tail, with dilation of both the main pancreatic duct and biliary tract noted on computed tomography...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Case Report Source Type: research
Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis
Objectives
Organ failure (OF) and infected necrosis (IN) are the most important predictors of mortality in necrotizing acute pancreatitis (AP). We studied the relationship between timing (onset and duration) and patterns of OF with mortality and the impact of IN on mortality.
Methods
Consecutive patients with necrotizing AP between January 2017 and February 2020 were analyzed retrospectively for OF and its impact on outcome. Organ failure was divided as single OF, simultaneous multiple OF (SiMOF) and sequential multiple OF (SeMOF). Mortality was compared for timing of onset, total duration and patterns of OF.
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Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Rectally Administered Low-Dose Diclofenac Has No Effect on Preventing Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Propensity Score Analysis
Conclusions
In our propensity score analysis, rectal administration of low-dose diclofenac was not shown to be useful in preventing PEP. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Reviewing the Outcomes of Different Treatment Approaches in Elderly Pancreatic Cancer Patients
Objectives
The incidence of pancreatic cancer is age dependent. Ninety percent of new diagnoses occur in patients older than 55 years. Despite the association with age and cancer, elderly patients are historically underrepresented in clinical trials. Thus, optimal management of elderly patients has a lack of data. The purpose of this retrospective study was to investigate the outcomes of palliative chemotherapy in elderly patients with pancreatic cancer compared with supportive care alone.
Methods
Unicentric data were reviewed on all elderly patients (defined as age>65 years) with a diagnosis of pancreatic cance...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Clinical Usefulness of [18F]-Fluoro-2-Deoxy-d-Glucose–Positron Emission Tomography/Computed Tomography for Distinguishing Between Autoimmune Pancreatitis and Pancreatic Cancer
Objectives
We investigated the [18F]-fluoro-2-deoxy-d-glucose (FDG)–positron emission tomography (PET)/computed tomography (CT) findings of pancreatic and extrapancreatic lesions in patients with autoimmune pancreatitis (AIP) and pancreatic cancer (PC) and evaluated the usefulness of 18F-FDG–PET/CT for differentiating between AIP and PC.
Methods
Eighty-five patients, 19 with AIP and 66 with PC, who underwent 18F-FDG–PET/CT were studied retrospectively. We evaluated the maximum standardized uptake value (SUVmax), patterns and distributions of FDG activity in pancreatic lesions, as well as FDG uptake in extr...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Exome Sequencing of Pancreatic Acinar Carcinoma Identified Distinctive Mutation Patterns
Conclusions
Distinct mutational signatures pathways were found in ACC and targeting them may improve clinical outcome. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Clinical Significance of Postoperative Antibiotic Treatment for Positive Islet Cultures After Total Pancreatectomy With Islet Autotransplantation
Conclusions
Beyond prophylactic antibiotics, empiric antibiotic treatment for a positive culture is not warranted and provides a rationale for the abandonment of routine cultures in TPIAT. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Cytoglobin as a Prognostic Factor for Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis of 75 Patients
Conclusions
Loss of Cygb may contribute to tumor recurrence and poor prognosis of PDAC by increases in angiogenic factor. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Fatty Pancreas Represents a Risk Factor for Acute Pancreatitis: A Pilot Study
Objectives
Fatty pancreas (FP), previously believed to be without clinical significance, recently has been shown to be associated with comorbid diseases. We aimed to explore whether FP predispose to acute pancreatitis.
Methods
Patients who underwent endoscopic ultrasound for hepatobiliary indications were included. Patients with pathological pancreato-biliary findings other than FP were excluded. The cohort was divided into patients with a history of pancreatitis (within 6 months of endoscopic ultrasound, group A) and patients without (group B).
Results
Overall, 189 patients were included. Sixty-one (32.3...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
A 3-Dimensional Coculture Model to Visualize and Monitor Interaction Between Pancreatic Cancer and Islet β Cells
Conclusions
Using rotary cell culture system, we have established a simple in vitro 3D pancreatic model. It is a flexible culture system that can easily be expanded with the addition of various stromal/neural components to further mimic in vivo conditions, thus enabling holistic investigation of the endocrine and exocrine pancreas. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Pyruvate and Glutamine Define the Effects of Cholecystokinin and Ethanol on Mitochondrial Oxidation, Necrosis, and Morphology of Rat Pancreatic Acini
Conclusions
The lack of sufficient substrate supply in vitro makes pancreatic acinar cells susceptible to necrosis caused by ethanol and CCK in clinically relevant concentrations. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Impact of Renal Function on S-1 + Radiotherapy for Locally Advanced Pancreatic Cancer: An Integrated Analysis of Data From 2 Clinical Trials
Objectives
S-1 monotherapy with concurrent radiotherapy (RT) is a standard of care for patients with locally advanced pancreatic cancer (LAPC). Although renal dysfunction increases S-1 monotherapy toxicity, its effect in S-1 with concurrent RT remains unknown. We evaluated the effect of renal function on the safety of S-1 with RT for LAPC.
Methods
We performed an integrated exploratory post hoc analysis of data from 2 prospective studies (JCOG1106 and LAPC-S1RT), where patients with LAPC received RT (50.4 Gy/28 fraction for 5.5 weeks) and concurrent S-1 (40 mg/m2 per dose, twice daily on the day of irradiation)....
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Gemcitabine Plus Nab-Paclitaxel Versus FOLFIRINOX in Locally Advanced, Unresectable Pancreatic Cancer: A Multicenter Observational Study (NAPOLEON Study)
Conclusions
The effects of FFX and GnP were similar but resulted in different toxicities, which could guide agent choice. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Osteoclast-Like Giant Cell Tumors of the Pancreas: Clinical Characteristics, Genetic Testing, and Treatment Modalities
Conclusions
Osteoclast-like giant cell carcinoma of the pancreas is an aggressive malignancy with poor prognosis. For patients with locoregional disease, surgical resection followed by adjuvant chemoradiation may play a role in extended disease-free survival. Metastatic disease presents a challenging entity to treat with little data to support any effective chemotherapy regimens. (Source: Pancreas)
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Original Articles Source Type: research
Decellularized Matrix Bioscaffolds: Implementation of Native Microenvironment in Pancreatic Tissue Engineering
Type 1 diabetes is an autoimmune disease, and its incidence is usually estimated in the range of 5% to 10%. Currently, the administration of exogenous insulin is the standard of care therapy. However, this therapy is not effective in some patients who may develop some chronic complications. Islet transplantation into the liver is another therapy with promising outcomes; however, the long-term efficacy of this therapeutic option is limited to a small number of patients. Because native extracellular matrix (ECM) components provide a suitable microenvironment for islet functions, engineering a 3-dimensional construct that rec...
Source: Pancreas - August 1, 2021 Category: Gastroenterology Tags: Reviews Source Type: research
