Effect of Different Modes of Administration of Dexmedetomidine Combined with Nerve Block on Postoperative Analgesia in Total Knee Arthroplasty
ConclusionsPerineural administration of DEX can significantly prolong the interval until patients report pain for the first time after TKA, relieve postoperative pain, reduce postoperative opioid dosage, and improve postoperative sleep quality and satisfaction with pain control.Trial RegistrationThe trial was registered at the Chinese Clinical Trial Registry, identifier ChiCTR1900025808. (Source: Pain and Therapy)
Source: Pain and Therapy - September 30, 2021 Category: Anesthesiology Source Type: research
Tapentadol Safety and Patient Characteristics Associated with Treatment Discontinuation in Cancer Therapy: A Retrospective Multicentre Study in Japan
ConclusionsThis study presents the safety profile of tapentadol and the characteristics of patients likely to discontinue this treatment owing to adverse events in the Japanese population. Prospective controlled trials are required to evaluate the safety of tapentadol and validate the present findings.Trial Registration NumberUMIN 000044282 (University Hospital Medical Information Network). (Source: Pain and Therapy)
Source: Pain and Therapy - September 28, 2021 Category: Anesthesiology Source Type: research
Association of Postpartum Pain Sensitivity and Postpartum Depression: A Prospective Observational Study
ConclusionIncreased postpartum pain sensitivity was closely associated with EPDS scores ≥ 10 points, and PSQ-C scores could be a reliable predictor. Moreover, gestational diabetes, low occurrence of breastfeeding, and low birth weight were the risk factors for EPDS scores ≥ 10 points.Trial RegistrationChiCTR.org.cn identifier, ChiCTR-2000033091. (Source: Pain and Therapy)
Source: Pain and Therapy - September 27, 2021 Category: Anesthesiology Source Type: research
Machine Learning in Pain Medicine: An Up-To-Date Systematic Review
ConclusionML is increasingly used in pain medicine and appears to be more effective compared to traditional statistical approaches in the diagnosis, classification, and management of pain. (Source: Pain and Therapy)
Source: Pain and Therapy - September 26, 2021 Category: Anesthesiology Source Type: research
Is There a Gender Difference in the Response to onabotulinumtoxinA in Chronic Migraine? Insights from a Real-Life European Multicenter Study on 2879 Patients
ConclusionsOur pooled analysis suggests that the response to BT-A is significant in both men and women with a small gender difference in favor of women. Men tended to stop the treatment more frequently than women. We emphasize the need for more gender-specific data on migraine treatments from randomized controlled trials and observational studies. (Source: Pain and Therapy)
Source: Pain and Therapy - September 26, 2021 Category: Anesthesiology Source Type: research
CT-Guided Coeliac Plexus Neurolysis in Patients with Intra-Abdominal Malignancy: A Retrospective Evaluation of 52 Palliative In-Patients
ConclusionsIn patients with intra-abdominal malignancy-related CAP, CPN is a safe and effective procedure which can provide long-lasting significant relief of background pain and BTcP. As part of a multimodal approach, CPN should be considered as an earlier option for pain management in these patients. (Source: Pain and Therapy)
Source: Pain and Therapy - September 21, 2021 Category: Anesthesiology Source Type: research
Intercostal Cryo Nerve Block in Minimally Invasive Cardiac Surgery: The Prospective Randomized FROST Trial
ConclusionsThe results of FROST demonstrated that intercostal CryoNB provided enhanced FEV1 score at 48 h postoperatively with optimized analgesic effectiveness versus SOC. Future larger prospective randomized trials are warranted to determine whether intercostal CryoNB has an opioid-sparing effect in patients undergoing Mini-HVS.Trial RegistrationClinicaltrials.gov identifier: NCT02922153. (Source: Pain and Therapy)
Source: Pain and Therapy - September 20, 2021 Category: Anesthesiology Source Type: research
The Role of Serratus Anterior Plane Block During in Video-Assisted Thoracoscopic Surgery
This article introduces the anatomical mechanism of the SAPB, diverse operation approaches, how to choose drugs and adjuvants, and the resulting impacted area r ange. It summarizes the advantages and disadvantages of the SAPB compared with other analgesic methods and posits that the SAPB is beneficial to the recovery of postoperative lung function, which provides more options for postoperative analgesia after VATS. (Source: Pain and Therapy)
Source: Pain and Therapy - September 19, 2021 Category: Anesthesiology Source Type: research
Clinical Efficacy of Conservative Treatment with Micronized Purified Flavonoid Fraction in Female Patients with Pelvic Congestion Syndrome
ConclusionIn women with PCS, conservative treatment with MPFF was associated with improved QoL and reduced symptom severity. MPFF may be considered an effective and safe treatment option for PCS in routine clinical practice. (Source: Pain and Therapy)
Source: Pain and Therapy - September 19, 2021 Category: Anesthesiology Source Type: research
Migraine Characteristics, Comorbidities, Healthcare Resource Utilization, and Associated Costs of Early Users of Erenumab in the USA: A Retrospective Cohort Study Using Administrative Claims Data
ConclusionsWe observed reductions in claims for important migraine characteristics, comorbidities, and a shift to decreased use of acute and preventive migraine medications —observations indicative of the real-world effectiveness of erenumab. Further examination is required as persistence to erenumab, which may be influenced by dose titration, appears to be an important factor in changes to healthcare resource utilization and costs. (Source: Pain and Therapy)
Source: Pain and Therapy - September 17, 2021 Category: Anesthesiology Source Type: research
Historical Review of Studies on Sacroiliac Fatty Nodules (Recently Termed “Back Mice”) as a Potential Cause of Low Back Pain
AbstractLow back pain is a widespread and poorly understood condition that is frequently diagnosed as non-specific low back pain. We were intrigued by the presence of painful sacroiliac nodules in patients with this condition. We conducted a historical review to elucidate this relationship. This chronicled review summarizes the overlooked literature from different countries, especially from around the 1950s, regarding the diagnosis and management of these painful nodules. Biopsies have confirmed the adipose nature of these nodules and revealed distinct pathological signs, including oedema and fascial fatty herniation. Stud...
Source: Pain and Therapy - September 16, 2021 Category: Anesthesiology Source Type: research
Status of N-of-1 Trials in Chronic Pain Management: A Narrative Review
AbstractN-of-1 trials are randomized controlled clinical trials conducted exclusively on a single patient. The ultimate aim of N-of-1 trials is to optimize a strategy in a particular individual. Chronic pain is a common but refractory clinical problem. Its diverse etiologies and broad variations among patients often lead to the requirement of individualizing medicine. Thus, chronic pain represents a classical condition for N-of-1 clinical trials. Studies have indicated that N-of-1 benefits patients with chronic pain, multiple comorbidities, and uncertain variations during therapies; however, this approach it is not yet ado...
Source: Pain and Therapy - September 16, 2021 Category: Anesthesiology Source Type: research
Caudad Insertion of Pedicle Screws Facilitates Interbody Distraction During Spondylolisthetic Vertebrae Restoration: A Retrospective Study
ConclusionsThese results suggest that the Caudad insertion trajectory technique of pedicle screws may be an ideal alternative for the treatment of DLS.Trial Registration NumberChinese Clinical Trial Registry (ChiCTR): ChiCTR1800020368. (Source: Pain and Therapy)
Source: Pain and Therapy - September 15, 2021 Category: Anesthesiology Source Type: research
A Qualitative Study to Explore Patient Perspectives of Prophylactic Treatment with OnabotulinumtoxinA for Chronic Migraine
ConclusionUnderstanding patients ’ perspective is an important part of clinical practice and may impact on decision-making. Qualitative data can provide a more holistic view of patient care and treatment insights that may not be evaluated during a clinical trial. This study revealed potential barriers to treatment that can inform future policy and practice. (Source: Pain and Therapy)
Source: Pain and Therapy - September 14, 2021 Category: Anesthesiology Source Type: research
Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis
ConclusionsClinical characteristics collected before treatment could be adopted to identify patients with MRP. (Source: Pain and Therapy)
Source: Pain and Therapy - September 12, 2021 Category: Anesthesiology Source Type: research
