Letter to the Editor Regarding “The Effect of Ultrasound-Guided Erector Spinae Plane Block Combined with Dexmedetomidine on Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial”
(Source: Pain and Therapy)
Source: Pain and Therapy - May 12, 2022 Category: Anesthesiology Source Type: research
A Response to: Letter to the Editor Regarding “The Effect of Ultrasound-Guided Erector Spinae Plane Block Combined with Dexmedetomidine on Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial”
(Source: Pain and Therapy)
Source: Pain and Therapy - May 12, 2022 Category: Anesthesiology Source Type: research
Efficacy, General Safety, and Joint Safety of Tanezumab in Japanese Patients with Osteoarthritis: Subgroup Analyses from Two Randomized, Phase 3 Studies
ConclusionObservations from the Japanese subgroup were generally consistent with the overall study populations. (Source: Pain and Therapy)
Source: Pain and Therapy - May 10, 2022 Category: Anesthesiology Source Type: research
Pharmacokinetics of Buprenorphine Buccal Film and Orally-administered Oxycodone in a Respiratory Study: An Analysis of Secondary Outcomes from a Randomized Controlled Trial
ConclusionThese results indicate that BBF may have a decreased risk of abuse and respiratory depression compared with the full µ-opioid receptor agonist oxycodone.Trial RegistrationClinicalTrials.gov identifier, NCT03996694. (Source: Pain and Therapy)
Source: Pain and Therapy - May 7, 2022 Category: Anesthesiology Source Type: research
Comparison of Ultrasound-Guided Caudal Epidural Blocks and Spinal Anesthesia for Anorectal Surgery: A Randomized Controlled Trial
ConclusionsUltrasound-guided caudal epidural blocks have higher patient satisfaction compared with spinal anesthesia.Trial RegistrationThis study was registered in the Chinese Clinical Trial Registry (ChiCTR 2000041026) on 06/12/2020. (Source: Pain and Therapy)
Source: Pain and Therapy - May 2, 2022 Category: Anesthesiology Source Type: research
Deep Brain Stimulation, Stereotactic Radiosurgery and High-Intensity Focused Ultrasound Targeting the Limbic Pain Matrix: A Comprehensive Review
AbstractChronic pain (CP) represents a socio-economic burden for affected patients along with therapeutic challenges for currently available therapies. When conventional therapies fail, modulation of the affective pain matrix using reversible deep brain stimulation (DBS) or targeted irreversible thalamotomy by stereotactic radiosurgery (SRS) and magnetic resonance (MR)-guided focused ultrasound (MRgFUS) appear to be considerable treatment options. We performed a literature search for clinical trials targeting the affective pain circuits (thalamus, anterior cingulate cortex [ACC], ventral striatum [VS]/internal capsule [IC]...
Source: Pain and Therapy - April 26, 2022 Category: Anesthesiology Source Type: research
Lasmiditan for Patients with Migraine and Contraindications to Triptans: A Post Hoc Analysis
ConclusionsIn pooled analyses from four trials, patients with and without triptan contraindications did not differ in their patterns of lasmiditan efficacy. Lasmiditan may be a treatment option in patients with contraindications to triptans.Trial Registration NumbersSAMURAI, NCT:02439320; SPARTAN, NCT:02605174; CENTURION, NCT:03670810; and MONONOFU, NCT:03962738. (Source: Pain and Therapy)
Source: Pain and Therapy - April 26, 2022 Category: Anesthesiology Source Type: research
Whole Body Pain Distribution and Risk Factors for Widespread Pain Among Patients Presenting with Abdominal Pain: A Retrospective Cohort Study
ConclusionMost patients with abdominal pain report additional pain locations at multiple other body sites, and non-localized pain persists 12 months after pain treatment. Screening for widespread pain and COPC at the initial visit may identify patients at higher risk for persistent or new-onset widespread pain, and interventions to reduce pain interference and anxiety may promote reversal of widespread pain. (Source: Pain and Therapy)
Source: Pain and Therapy - April 25, 2022 Category: Anesthesiology Source Type: research
Practical Insights on the Identification and Management of Patients with Chronic Migraine
AbstractChronic migraine (CM) is one of the most disabling diseases, and it is commonly misdiagnosed and mistreated. Despite the importance of a timely and accurate diagnosis for the effective management of CM, recent surveys have shown that only 20 –25% of individuals with CM receive a correct diagnosis. The obvious consequences of misdiagnosed CM are prolongation of symptoms and their associated effects on disability and health-related quality of life. Additionally, mistreatment of CM can lead to acute medication overuse headache with escal ation of headache and end organ damage. Ideally, a diagnosis of CM should be ma...
Source: Pain and Therapy - April 20, 2022 Category: Anesthesiology Source Type: research
Clinical Observation of the Effects of Oral Opioid on Inflammatory Cytokines and Gut Microbiota in Patients with Moderate to Severe Cancer Pain: A Retrospective Cohort Study
ConclusionOral oxycodone can cause abnormal changes in cytokine levels and gut microbiota of patients with moderate to severe cancer pain, prompting chronic systemic inflammation. Analgesic tolerance induced by long-term oxycodone use could be closely related to the consistent upregulation of IL-6 and TNF- α levels. (Source: Pain and Therapy)
Source: Pain and Therapy - April 18, 2022 Category: Anesthesiology Source Type: research
Radiofrequency Ablation of the Superior Cluneal Nerve: A Novel Minimally Invasive Approach Adopting Recent Anatomic and Neurosurgical Data
ConclusionsThis is the first report of both technique and outcomes for radiofrequency ablation of superior cluneal neuralgia. This series suggests that RFA of the SCn is a suitable intervention for the treatment of SCN; 21.7% of patients reported a mean of 95% analgesia for a mean duration of 111.2 days, and the remaining 78.3% of patients reported ongoing relief with a mean of 92.3% analgesia at last follow-up (mean 92.1 days). There were no serious adverse events. (Source: Pain and Therapy)
Source: Pain and Therapy - April 17, 2022 Category: Anesthesiology Source Type: research
Safety of Conventional and Pulsed Radiofrequency Lesions of the Dorsal Root Entry Zone Complex (DREZC) for Interventional Pain Management: A Systematic Review
ConclusionsThis systematic review indicates that the use of RFA lesion of the DREZC for interventional pain management is very safe. There were no serious adverse effects with a sizable sample of randomized controlled trial (RCT), prospective observational, and retrospective studies. (Source: Pain and Therapy)
Source: Pain and Therapy - April 17, 2022 Category: Anesthesiology Source Type: research
Extracranial Radiofrequency Treatment for Painful Tic Convulsif Syndrome Under Local Anesthesia
ConclusionExtracranial radiofrequency therapy can provide safe and economical treatment for patients with painful tic convulsif syndrome. (Source: Pain and Therapy)
Source: Pain and Therapy - April 16, 2022 Category: Anesthesiology Source Type: research
Progress, Challenges, and Prospects of Research on the Effect of Gene Polymorphisms on Adverse Reactions to Opioids
AbstractThe abuse of opioids has become one of the most serious concerns in the world. Opioid use can cause serious adverse reactions, including respiratory depression, postoperative nausea and vomiting, itching, and even death. These adverse reactions are also important complications of clinical application of opioid drugs that may affect patient safety and recovery. Due to the fear of adverse reactions of opioids, clinicians often do not dare to use opioids in an adequate or appropriate amount, thus affecting the clinical medication strategy and the quality of treatment for patients. The prediction of adverse reactions t...
Source: Pain and Therapy - April 16, 2022 Category: Anesthesiology Source Type: research
Multimodal Analgesia with Extended-Release Dinalbuphine Sebacate for Perioperative Pain Management in Upper Extremity Trauma Surgery: A Retrospective Comparative Study
ConclusionThis result suggests that extended-release DS is a suitable analgesic incorporated in MMA and a promising solution to the misuse and abuse of opioids. (Source: Pain and Therapy)
Source: Pain and Therapy - April 15, 2022 Category: Anesthesiology Source Type: research
