Pregabalin and Gabapentin in Patients with Spinal Cord Injury-Related Neuropathic Pain: A Network Meta-Analysis
ConclusionsThis study revealed that for patients with SCI-related neuropathic pain, pregabalin was the most effective for relieving pain, whereas gabapentin performed better in aspects associated with drug therapy-related safety. (Source: Pain and Therapy)
Source: Pain and Therapy - September 7, 2021 Category: Anesthesiology Source Type: research
Endoscopic Transforaminal Lumbar Foraminotomy: A Systematic Review and Meta-Analysis
ConclusionTELF is a useful and safe method to achieve decompression in foraminal stenosis. This technique is indicated in the elderly or patients with comorbidities. Preoperative planning is paramount in determining the foraminal size and endoscope trajectory. A diamond burr is recommended because it has an advantage over the regular endoscopic shaver in bleeding control and complication avoidance. (Source: Pain and Therapy)
Source: Pain and Therapy - September 6, 2021 Category: Anesthesiology Source Type: research
Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics
ConclusionsWe conclude that NeP contributes to pain in AS patients. (Source: Pain and Therapy)
Source: Pain and Therapy - September 4, 2021 Category: Anesthesiology Source Type: research
Pharmacological Advances in Opioid Therapy: A Review of the Role of Oliceridine in Pain Management
AbstractProblems with the treatment of acute pain may arise when a patient is opioid-tolerant, such as those on chronic therapy with opioids or opiate replacement therapy, those who misuse opioids, and those who are in recovery. While some of the adverse effects of opioid medications are well known, it is also important to recognize the roles of tolerance and hyperalgesia. Oliceridine can target and modulate a novel μ-receptor pathway. The G protein-biased agonism of oliceridine allows for effective re-sensitization and desensitization of the mu-opioid receptor, which decreases the formation of opioid tolerance in patient...
Source: Pain and Therapy - September 4, 2021 Category: Anesthesiology Source Type: research
Peripheral Nerve Stimulation for Chronic Pain: A Systematic Review of Effectiveness and Safety
AbstractPeripheral nerve stimulation (PNS) was the first application of neuromodulation. Widespread application of PNS was limited by technical concerns. Recent advances now allow the percutaneous placement of leads with ultrasound or fluoroscopic guidance, while the transcutaneous powering of these leads removes the need for leads to cross major joints. This systematic review was written to assess the current status of high-quality evidence supporting the use of PNS for pain conditions treated by interventional pain physicians. The available literature on PNS, limited to conditions treated by interventional pain physician...
Source: Pain and Therapy - September 3, 2021 Category: Anesthesiology Source Type: research
Restorative Neurostimulation for Chronic Mechanical Low Back Pain: Results from a Prospective Multi-centre Longitudinal Cohort
ConclusionThis real-world sample of patients shows that restorative neurostimulation can provide substantial and durable benefit to a cohort of patients that have traditionally had few reliable treatment options. Our findings support the continued used of this therapy in well-selected patients.Trial RegistrationClinicalTrials.gov Identifier: NCT01985230. (Source: Pain and Therapy)
Source: Pain and Therapy - September 3, 2021 Category: Anesthesiology Source Type: research
A Prospective Study to Examine the Association of the Foramen Ovale Size with Intraluminal Pressure of Pear-Shaped Balloon in Percutaneous Balloon Compression for Trigeminal Neuralgia
ConclusionsPreoperative assessment of FO may be a potential predictor of intraluminal pressure to reach a pear-shaped balloon during PBC treatment. Narrow FO is associated lower intraluminal balloon pressure. (Source: Pain and Therapy)
Source: Pain and Therapy - August 30, 2021 Category: Anesthesiology Source Type: research
Prevalence and Characteristics of Chronic Pain Among Patients in Portuguese Primary Care Units
ConclusionGiven the high prevalence of CP, strategies to improve the quality of life of these patients and decrease the negative impacts, as well as awareness campaigns to increase the populations ’ knowledge of this condition, are essential for the suitable and timely treatment of CP. (Source: Pain and Therapy)
Source: Pain and Therapy - August 28, 2021 Category: Anesthesiology Source Type: research
A Response to: Letter to the Editor regarding “Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study”
(Source: Pain and Therapy)
Source: Pain and Therapy - August 24, 2021 Category: Anesthesiology Source Type: research
Letter to the Editor regarding “Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study”
(Source: Pain and Therapy)
Source: Pain and Therapy - August 24, 2021 Category: Anesthesiology Source Type: research
Demographics, Pain Characteristics and Diagnostic Classification Profile of Chronic Non-Cancer Pain Patients Attending a Canadian University-Affiliated Community Pain Clinic
ConclusionOur study highlights regional differences between CNCP population phenotypes. Recognition of biomedical, psychological and socio-environmental factors affecting pain should be considered for patient stratification and rational approaches to treatment, as “one size treatment does not fit all”. (Source: Pain and Therapy)
Source: Pain and Therapy - August 19, 2021 Category: Anesthesiology Source Type: research
Musculoskeletal Pain Due to Wheelchair Use: A Systematic Review and Meta-Analysis
ConclusionsMusculoskeletal pain as a result of wheelchair use is very common amongst wheelchair users. Management of pain should follow national and international guidelines. Optimal adjustment of seating position may prevent pain, and is important to be taken into consideration. (Source: Pain and Therapy)
Source: Pain and Therapy - August 13, 2021 Category: Anesthesiology Source Type: research
Sex-Specific Pharmacotherapy for Back Pain: A Proof-of-Concept Randomized Trial
ConclusionsThese results provide the first evidence for preventing transition to chronic back pain using sex-specific pharmacotherapy. These provocative observations require confirmation in a larger study. ClinicalTrials.gov identifier: NCT01951105. (Source: Pain and Therapy)
Source: Pain and Therapy - August 10, 2021 Category: Anesthesiology Source Type: research
Comparison of Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) and Laparoendoscopic Single-Site (LESS) Hysterectomy on Postoperative Pain Reduction: A Randomized Pilot Study
ConclusionsvNOTES hysterectomy can be safely performed for benign uterine disease requiring hysterectomy. However, vNOTES hysterectomy might be associated with higher postoperative vaginal pain intensity compared to LESS hysterectomy.Trial RegistrationCRIS identifier KCT0004605. (Source: Pain and Therapy)
Source: Pain and Therapy - August 10, 2021 Category: Anesthesiology Source Type: research
Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross-Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China
ConclusionModerate to severe neuropathic pain in PDN was identified in 73.11% of participants. Age, diabetic duration, depression history, PHQ-9 score, GAD-7 score and FBG were risk factors for VAS pain scores. PAD was protective factor. The majority of pain relief therapies prescribed were in accordance with guidelines.Trial registrationClinicalTrials.gov identifier, NCT03520608, retrospectively registered, 2018-05-11. (Source: Pain and Therapy)
Source: Pain and Therapy - August 7, 2021 Category: Anesthesiology Source Type: research
