Pain Management with Inhalation of Methoxyflurane Administrated by Non-Medical Ski Patrol: A Quality Assessment Study
ConclusionsMethoxyflurane is feasible as a first-line analgesic administered by a non-medical ski patrol in a responsibly organized system. Early pain management with inhalation of methoxyflurane provides good perceived effect with mild adverse events and can be of great value in settings where few alternatives for pain management are available. (Source: Pain and Therapy)
Source: Pain and Therapy - August 14, 2023 Category: Anesthesiology Source Type: research
Exploring the Rules of Related Parameters in Transcutaneous Electrical Nerve Stimulation for Cancer Pain Based on Data Mining
ConclusionIn the treatment of cancer pain using TENS, it is recommended to use a current frequency of 2/100 Hz, a treatment frequency of once a day, a retention time of 30 min, and the dilatational wave. The electrode positions were primarily selected from Ashi point, Back shu point, Sanyinjiao (SP06), Zusanli (ST36), Hegu (LI04), Jiaji point, and Neiguan (PC06) to achieve the best analgesic effect. (Source: Pain and Therapy)
Source: Pain and Therapy - August 14, 2023 Category: Anesthesiology Source Type: research
Intraoperative Sufentanil Consumption and the Risk of Postoperative Nausea and/or Vomiting: A Retrospective Observational Study
ConclusionsIntraoperative sufentanil injection with a twSuf higher than 0.21 μg kg−1 h−1 increased the risk of PONV in patients undergoing thoracoscopic surgery under general anesthesia after a preoperative thoracic paravertebral block. (Source: Pain and Therapy)
Source: Pain and Therapy - August 9, 2023 Category: Anesthesiology Source Type: research
Preoperative Versus Perioperative Risk Factors for Delayed Pain and Opioid Cessation After Total Joint Arthroplasty: A Prospective Cohort Study
ConclusionsThese findings highlight preoperative opioid use as a key determinant of delayed postoperative opioid cessation, while postoperative elevations in depressive symptoms and pain catastrophizing are associated with persistent pain after total joint arthroplasty providing the rationale for continued risk stratification before and after surgery to identify patients at highest risk for these distinct outcomes. Interventions targeting these perioperative risk factors may prevent prolonged postoperative pain and opioid use. (Source: Pain and Therapy)
Source: Pain and Therapy - August 9, 2023 Category: Anesthesiology Source Type: research
The Impact of Burst Motor Cortex Stimulation on Cardiovascular Autonomic Modulation in Chronic Pain: A Feasibility Study for a New Approach to Objectively Monitor Therapeutic Effects
ConclusionFour months of adjunctive burstMCS was associated with an increase in parameters reflecting both total and parasympathetic autonomic modulation and baroreceptor reflex sensitivity. In contrast, sympathetic tone declined in our three patients, suggesting stimulation-associated improvement not only in subjectively perceived VAS pain scores, but also in objectifiable parameters of autonomic cardiovascular modulation. (Source: Pain and Therapy)
Source: Pain and Therapy - August 2, 2023 Category: Anesthesiology Source Type: research
Proposal of a Route Map for Cervical Spinal Ultrasonography: A Simple and Clear Learning Tool for Beginners
AbstractSpinal ultrasonography has increasingly been used to image axial structures from the cervical to sacral region in recent years. In this work, we propose a comprehensive, systematic cervical scanning protocol that we refined as a route map, especially for beginners, to facilitate teaching, learning, diagnosis, and treatment in clinical pain practice. As a simple and clear tool to demonstrate the scanning protocol, the route map is delineated with rectangles, lines, and arrows. The rectangles represent the positions of the transducer, the arrows indicate route directions, and the lines show the routes of transducer m...
Source: Pain and Therapy - July 30, 2023 Category: Anesthesiology Source Type: research
Correction to: Delphi-Based Expert Consensus Statements for the Management of Percutaneous Radiofrequency Neurotomy in the Treatment of Lumbar Facet Joint Syndrome
(Source: Pain and Therapy)
Source: Pain and Therapy - July 29, 2023 Category: Anesthesiology Source Type: research
First Report on Real-World Outcomes with Evoked Compound Action Potential (ECAP)-Controlled Closed-Loop Spinal Cord Stimulation for Treatment of Chronic Pain
ConclusionsThese initial ‘real-world’ data on ECAP-controlled, closed-loop SCS in a real-world clinical setting appear to be promising, as they provide novel insights of the beneficial effect of ECAP-controlled, closed-loop SCS in a real-world setting. The presented results demonstrate a noteworthy maintenance of pain r elief over 12 months and corroborate the outcomes observed in the AVALON prospective, multicenter, single-arm study and the EVOKE double-blind, multicenter, randomized controlled trial.Trial RegistrationThe data collection is registered on the International Clinical Trials Registry Platform (Trial NL78...
Source: Pain and Therapy - July 23, 2023 Category: Anesthesiology Source Type: research
Burden and Unmet Needs in Migraine Patients: Results from the OVERCOME (Spain) Study
ConclusionsResults of the OVERCOME (Spain) survey reveal the substantial burden of migraine, which is directly linked to headache frequency. However, most patients experiencing frequent headaches and eligible for migraine preventives are currentlynot taking them. Findings highlight the importance of addressing unmet needs for people with migraine in Spain. (Source: Pain and Therapy)
Source: Pain and Therapy - July 16, 2023 Category: Anesthesiology Source Type: research
Tianeptine, an Antidepressant with Opioid Agonist Effects: Pharmacology and Abuse Potential, a Narrative Review
AbstractTianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA). Despite its lack of approval by the FDA, tianeptine has been distributed online and at small retail locations. The term “gas station drugs” refers to a wide range of substances typically available for purchase from ga...
Source: Pain and Therapy - July 15, 2023 Category: Anesthesiology Source Type: research
The Relationship between Blood Lead Level and Chronic Pain in US Adults: A Nationwide Cross-Sectional Study
ConclusionA higher BLL was associated with a higher risk of chronic pain. Further research is warranted to investigate whether a causal relationship exists between the two, as well as potential underlying mechanisms. (Source: Pain and Therapy)
Source: Pain and Therapy - June 30, 2023 Category: Anesthesiology Source Type: research
Improving to Four or Fewer Monthly Headache Days Per Month Provides a Clinically Meaningful Therapeutic Target for Patients with Chronic Migraine
ConclusionParticipants improving to ≤ 4 MHDs reported less acute medication use and improved patient-reported outcomes, suggesting that 4 MHDs may be a useful patient-centric treatment target when treating CM.Trial registrationClinicalTrials.gov (Identifier: NCT02974153) (https://clinicaltrials.gov/ct2/show/NCT02974153). (Source: Pain and Therapy)
Source: Pain and Therapy - June 28, 2023 Category: Anesthesiology Source Type: research
Comparison of Recovery Effect for Sufentanil vs. Remifentanil Anesthesia in Elderly Patients Undergoing Curative Resection for Hepatocellular Carcinoma
ConclusionsSufentanil was associated with improved hemodynamic and respiratory function, less stress response, less inhibition of cellular immunity, and similar adverse reactions compared with remifentanil. (Source: Pain and Therapy)
Source: Pain and Therapy - June 24, 2023 Category: Anesthesiology Source Type: research
Efficacy of Percutaneous Adhesiolysis in Managing Low Back and Lower Extremity Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials
ConclusionThe evidence is level I to II or strong to moderate based on five high-quality and two moderate-quality RCTs, with 1 year follow-up that percutaneous adhesiolysis is efficacious in the treatment of chronic refractory low back and lower extremity pain. (Source: Pain and Therapy)
Source: Pain and Therapy - June 24, 2023 Category: Anesthesiology Source Type: research
Effects of S-ketamine on Postoperative Recovery Quality and Inflammatory Response in Patients Undergoing Modified Radical Mastectomy
ConclusionsA high dose of s-ketamine improved the quality of recovery at 24 h after surgery, as well as alleviated the inflammatory response without increasing the incidence of adverse effects. (Source: Pain and Therapy)
Source: Pain and Therapy - June 24, 2023 Category: Anesthesiology Source Type: research
