Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study
ConclusionsIn lung transplantation, Cryo was found to be safe with analgesic effectiveness similar to TEA. Cryo may be advantageous in this complex patient population, as it can be used in all clinical scenarios and eliminates risks and delays associated with TEA. (Source: Pain and Therapy)
Source: Pain and Therapy - October 23, 2022 Category: Anesthesiology Source Type: research
A Prospective, Observational, Open-Label, Non-Randomized, Multicenter Study Measuring Functional Outcomes in a Novel Interspinous Fusion Device in Subjects with Low Back Pain: REFINE Study
ConclusionsThis interim analysis of the first 20% of the enrolled patients out to 3 months was to determine safety of the procedure and report on adverse events, acknowledging the heterogeneity of surgical specialty. Further follow-up and greater numbers are needed as the study is ongoing.Trial RegistrationClinicalTrials.gov identifier, NCT05504499. (Source: Pain and Therapy)
Source: Pain and Therapy - October 20, 2022 Category: Anesthesiology Source Type: research
Efficacy and Safety of Methylprednisolone for Lung Surgery: a Systematic Review and Meta-analysis of Randomized Controlled Trials
ConclusionsOur findings suggest that the administration of MP contributed to an insignificant relief in acute postoperative pain for lung surgery in a clinical setting. Future studies should focus on exploring the role of MP in reducing pulmonary and surgical-related complications after lung surgery.Clinical Trial NumberPROSPERO registration number CRD42022314224. (Source: Pain and Therapy)
Source: Pain and Therapy - October 19, 2022 Category: Anesthesiology Source Type: research
Chronic Non-cancer Pain Management in a Tertiary Pain Clinic Network: a Retrospective Study
ConclusionOpioids are useful in managing moderate or severe chronic pain. Multimodal approaches are used for the management of chronic pain. Moreover, it is not clear how patients are addressed to access different pain clinics (spoke versus hub) networks. More widespread adoption is needed for an interdisciplinary approach to managing chronic pain and adopting guideline recommendations, and rigorous research is required to provide more substantial evidence and support clinical practice. (Source: Pain and Therapy)
Source: Pain and Therapy - October 17, 2022 Category: Anesthesiology Source Type: research
Prevalence and Predictors of Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis
ConclusionThis study preliminarily determined the incidence of CPSP after VATS based on the existing literature. Female sex, age, and acute pain were identified as risk factors for CPSP after VATS, and other potential risk factors were also identified and analyzed. However, as a result of the inclusion of retrospective studies and inevitable limitations in this systematic review and meta-analysis, the results of this study still need to be verified by large-scale prospective clinical studies.Trial RegistrationCRD42022323179. (Source: Pain and Therapy)
Source: Pain and Therapy - October 13, 2022 Category: Anesthesiology Source Type: research
The Effect of the Magnesium Sulfate in Ultrasound-Guided Quadratus Lumborum Block on Postoperative Analgesia: A Randomized Controlled Trial
ConclusionMagnesium sulfate as an adjuvant to ropivacaine in ultrasound-guided QLB prolongs the duration of analgesia, decreases analgesic requirements, and improves patient satisfaction without significant side effects.Trial RegistrationChinese Clinical Trial Registry, ChiCTR1900027066. (Source: Pain and Therapy)
Source: Pain and Therapy - October 13, 2022 Category: Anesthesiology Source Type: research
Efficacy and Safety of Pregabalin Prolonged Release –Etoricoxib Combination Compared to Etoricoxib for Chronic Low Back Pain: Phase 3, Randomized Study
ConclusionFDC of pregabalin and etoricoxib provided significant benefits in reducing pain and improving functional status compared with etoricoxib alone in patients with CLBP. Pregabalin prolonged release –etoricoxib FDC could be one of the treatment options for early and sustained pain relief and improvement in quality-of-life in treating CLBP as it addresses both neuropathic and nociceptive components of pain.Trial RegistrationCTRI/2018/10/015886. (Source: Pain and Therapy)
Source: Pain and Therapy - October 12, 2022 Category: Anesthesiology Source Type: research
Inpatient Constipation Among Migraine Patients Prescribed Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies and Standard of Care Antiepileptic Drugs: A Retrospective Cohort Study in a United States Electronic Health Record Database
ConclusionPatients initiating erenumab had similar risk of inpatient constipation within 90 days of treatment initiation versus patients initiating other CGRP mAbs, and lower risk versus patients initiating AEDs. These findings provide context to events observed during post-marketing surveillance. (Source: Pain and Therapy)
Source: Pain and Therapy - October 7, 2022 Category: Anesthesiology Source Type: research
Different Profiles of the Triad of Lysophosphatidylcholine, Lysophosphatidic Acid, and Autotaxin in Patients with Neuropathic Pain Diseases: a Preliminary Observational Study
AbstractThe mechanisms underlying neuropathic pain remain unclear. Lysophosphatidic acid (LPA) is a bioactive phospholipid derived mainly from lysophosphatidylcholine (LPC) by extracellular autotaxin (ATX), and has attracted attention as a candidate biomarker of neuropathic pain. We aimed to investigate the levels of LPA, LPC, and ATX in patients with lumbar spinal canal stenosis (LSCS) or other neuropathic pain diseases, and to distinguish the underlying mechanism of LSCS from other neuropathic pain conditions. Furthermore, the levels of phosphorylated neurofilament heavy chain (pNF-H), an objective surrogate marker of ax...
Source: Pain and Therapy - October 7, 2022 Category: Anesthesiology Source Type: research
Effects of Systemic Lidocaine Versus Dexmedetomidine on the Recovery Quality and Analgesia After Thyroid Cancer Surgery: A Randomized Controlled Trial
ConclusionSystemic lidocaine and dexmedetomidine had similar effects on enhancing the quality of recovery, alleviating the intensity of pain and reducing the incidence of PONV after thyroid cancer surgery. However, dexmedetomidine may result in bradycardia. Therefore, lidocaine was superior to dexmedetomidine.Trial registrationChiCTR.org.cn (ChiCTR2000038442). Registered on September 22, 2020. (Source: Pain and Therapy)
Source: Pain and Therapy - October 6, 2022 Category: Anesthesiology Source Type: research
Correction to: Efficacy and Safety of Add-on Mirogabalin to NSAIDs in Lumbar Spinal Stenosis with Peripheral Neuropathic Pain: A Randomized, Open-Label Study
(Source: Pain and Therapy)
Source: Pain and Therapy - October 6, 2022 Category: Anesthesiology Source Type: research
Comparison of Distal and Proximal Local Steroid Injection for Carpal Tunnel Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials
ConclusionAlthough providing similar improvement in pain relief or function improvement, the distal approach is superior to the proximal approach in terms of timing, without increasing other side effects. Further high-quality randomized studies are required to confirm these results. (Source: Pain and Therapy)
Source: Pain and Therapy - October 5, 2022 Category: Anesthesiology Source Type: research
The Effect of Manipulation Under Anesthesia for Secondary Frozen Shoulder: A Randomized Controlled Trial
ConclusionTo treat secondary frozen shoulder with MUA, this treatment could achieve better therapeutic effects on improvement of function, pain, and passive ROM than CLX did.Clinical Trial RegistrationThe trial was registered atwww.chictr.org.cn, identifier ChiCTR2200060269. (Source: Pain and Therapy)
Source: Pain and Therapy - September 29, 2022 Category: Anesthesiology Source Type: research
Letter to the Editor Regarding “Comparison of Ultrasound-Guided Erector Spinae Plane Block and Oblique Subcostal Transverse Abdominis Plane Block for Postoperative Analgesia in Elderly Patients After Laparoscopic Colorectal Surgery: A Prospective Randomized Study”
(Source: Pain and Therapy)
Source: Pain and Therapy - September 29, 2022 Category: Anesthesiology Source Type: research
Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
ConclusionsThe clinical success ratio of this technique was 74.8%. Although the incidence of adverse events was 40.8%, all events were mild and no serious adverse events were observed. The findings demonstrate the efficacy and safety of our NSNB in patients with intractable cancer pain. (Source: Pain and Therapy)
Source: Pain and Therapy - September 28, 2022 Category: Anesthesiology Source Type: research
