Effect of Atropine 0.01% Eye Drops on the Difference in Refraction and Axial Length Between Right and Left Eye
This study sought to determine whether the application of 0.01% atropine eye drops could impact the disparity in refraction and axial length (AL) between the right and left eyes in Chinese children.
Methods: The study was designed as a double-blind, placebo-controlled randomized trial. A total of 220 children aged 6-12 years were recruited from the Beijing Tongren Hospital in Beijing, China. Participants were randomized in a 1:1 ratio and were prescribed 0.01% atropine or placebo eye drops to be administered once a night to both eyes for the duration of one year. The cycloplegic refraction and AL was recorded including ba...
Source: Ophthalmic Research - January 5, 2023 Category: Opthalmology Source Type: research
Topographic Differences in Superficial Macular Vessel Density in Eyes with Early Primary Open-Angle Glaucoma and Normal Tension Glaucoma
Introduction: To compare macular vascular microcirculation in early primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and normal subjects.
Methods: 99 patients with early glaucoma (99 eyes: 60 POAG and 39 NTG) and 78 normal subjects were included. All subjects underwent optical coherence tomography angiography (OCTA) scan at 6 ×6 mm macular area. Macular vessel density (VD) and perfusion density (PD) and 9 sectors were compared between the controls, POAG and NTG groups. Linear regression analysis was used to investigate the relationship between VD and other variables including macular PD, signal strength...
Source: Ophthalmic Research - January 5, 2023 Category: Opthalmology Source Type: research
How Medication Adherence Affects Disease Management in Veterans with Glaucoma: Lessons Learned from a Clinical Trial
Conclusions: A multi-faceted intervention that improved medication adherence for glaucoma for 6 months did not affect the clinical outcomes measured at 12 months post randomization. Twelve months may not be long enough to see th e clinical effect of this intervention or more than 6 months of intervention are needed. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 5, 2023 Category: Opthalmology Source Type: research
Vault-correlated efficacy and safety of Implantable Collamer Lens V4c implantation for myopia in patients with shallow anterior chamber depth
Introduction: To evaluate efficacy and safety outcomes after implantation of the Visian Implantable Collamer Lens (ICL V4c) in myopia patients with shallow anterior chamber depth (ACD).
Methods: This retrospective study followed 163 eyes of 94 patients for at least 24 months. Uncorrected distance visual acuity, corrected distance visual acuity, intraocular pressure (IOP), manifest refraction, vault, endothelial cell density (ECD), anterior chamber angle (ACA), anterior chamber volume (ACV) and the distance from the corneal endothelium to the central ICL (C-ICL) were measured during follow-ups. Spearman ’s correlation an...
Source: Ophthalmic Research - January 3, 2023 Category: Opthalmology Source Type: research
Current management of Inherited Retinal Degenerations (IRD) patients in Europe. Results of a 2 years follow-up multinational survey by the European Vision Institute Clinical Research Network - EVICR.net
Conclusion: This second multinational survey on management of IRDs in Europe highlights persistent important differences in the number of IRD patients managed per center, comparable diagnostic work-up, and increasing genotyping in diagnost ic laboratories. The important increase of involvement of centers in natural history and gene therapy trials reflects the rapidly evolving field of gene therapy development. The survey provides important follow-up data for researchers, clinicians, care givers, patient advocate groups, pharmaceutical companies and investors. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 2, 2023 Category: Opthalmology Source Type: research
Risk Factors for Fellow Eye Involvement in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy
Introduction: To investigate the possible risk factors for fellow eye involvement in patients with nonarteritic anterior ischemic optic neuropathy (NAION).
Methods: A total of 113 patients with unilateral NAION attack were included and divided into two groups according to whether fellow eye involvement was present over a mean follow-up period of 2.70 years (P25 –P75: 0.77–3.54 years). General characteristics (including age, sex, diabetes, hypertension, hyperlipidemia and obstructive sleep apnea syndrome) and ocular characteristics (including initial best corrected visual acuity, initial visual field damage of the firs...
Source: Ophthalmic Research - December 9, 2022 Category: Opthalmology Source Type: research
Comparison of multicolor scanning laser imaging and color fundus photography in evaluating vessel whitening in branch retinal vein occlusion
This study aimed to compare the identification of retinal vessel whitening in BRVO using MCI by scanning confocal laser versus conventional white flash color fundus photography (CFP).
Method s: Paired images of consecutive patients diagnosed with BRVO who underwent same-day MCI and CFP were reviewed. Visualization of vessel whitening on MCI and CFP was graded and scored using a scale by two masked graders. A longitudinal analysis of the vessel grading score was performed to evaluate the vessel whitening detection by MCI. A correlation analysis was conducted between vessel whitening on MCI and the measured area of retinal i...
Source: Ophthalmic Research - December 8, 2022 Category: Opthalmology Source Type: research
Acknowledgement to Reviewers
Ophthalmic Res 2022;65:730 –731 (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 8, 2022 Category: Opthalmology Source Type: research
Analysis of the optic nerve head microcirculation using OCT-A and the upstream macrocirculation using CDI in low- and high-tension glaucoma patients
Introduction: To analyze the optic nerve head (ONH) microcirculation using optical coherence tomography angiography (OCT-A) and the upstream macrocirculation using color Doppler imaging (CDI) in low-tension and high-tension glaucoma (LTG and HTG, respectively). Methods: This cross-sectional study included 67 eyes of 67 HTG patients, 55 eyes of 55 LTG patients, and 42 eyes of 42 healthy controls. We recorded the complete ophthalmological examination, visual fields, retinal nerve fiber layer (RNFL) thickness, ONH vessel density (VD) measured using OCT-A, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resisti...
Source: Ophthalmic Research - December 6, 2022 Category: Opthalmology Source Type: research
Retinal neurodegeneration in euglycemic hyperinsulinemia, prediabetes, and diabetes
Diabetic retinopathy (DR) is a challenging public health problem mainly because of its growing prevalence and risk of blindness. In general, our current knowledge and practice have failed to prevent the onset or progression of DR to sight-threatening complications. While there are treatment options for sight-threatening complications of DR, it is crucial to pay more attention to the early stages of DR to decrease its prevalence. Growing evidence suggests many pathologic changes occur before clinical presentations of DR in euglycemic hyperinsulinemia, prediabetes, and diabetes. These pathological changes occur in retinal ne...
Source: Ophthalmic Research - December 2, 2022 Category: Opthalmology Source Type: research
The Effect of Prostaglandin Analogues on Central Corneal Thickness of Patients with Glaucoma or Ocular Hypertension: a systematic review
Conclusions: Th e pooled effects from current literature suggest that PGAs use could reduce CCT of patients with glaucoma or OHT slightly but significantly, and this effect is more pronounced in the first two years. This reminds us that we need to pay attention to the changes in CCT during the first two years of PG A use in case we misestimate intraocular pressure (IOP) and the efficacy of the PGA. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 1, 2022 Category: Opthalmology Source Type: research
Discordance between anterior segment anatomy and axial length in cataract surgery candidates in france
Introduction: To study ocular biometric data and their association with age and sex in a population of cataract surgery candidates. To assess the proportion of inhomogeneous eyes and the ratio anterior segment (AS) to axial length (AL). Multicentric cross-sectional analysis between April 2008 and May 2021 in public and private ophthalmic institutions in Montpellier, France. Individuals ≥ 40 years old who underwent ocular biometry before cataract surgery were included.
Methods: Right phakic eyes were included. Ocular biometrics were measured by using the Lenstar LS900 device. We defined AS as anterior chamber depth (ACD) ...
Source: Ophthalmic Research - December 1, 2022 Category: Opthalmology Source Type: research
Erratum
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 30, 2022 Category: Opthalmology Source Type: research
Plasma Level of Apelin as a Promising Factor for Retinopathy of Prematurity
Introduction: To investigate the relevance of plasma levels of apelin and other risk factors in infants with retinopathy of prematurity (ROP).
Methods: This was a single-center cross-sectional study. Fifty preterm infants with ROP and 50 preterm infants without ROP were enrolled. The analysis included evaluation of gestational age, birth weight, and measurement of plasma concentrations of apelin, vascular endothelial growth factor (VEGF), erythropoietin (EPO), and insulin-like growth factor (IGF-1) using enzyme-linked immunosorbent assay.
Results: The mean BW and GA of babies with ROP were considerably lower than those w...
Source: Ophthalmic Research - November 28, 2022 Category: Opthalmology Source Type: research
The First-Year Variation in Central Retinal Thickness Predicts Legal Blindness in Patients with Neovascular Age-Related Macular Degeneration
Conclusions: First-year variability of CRT was predictive of long-term visual outcomes in patients with nAMD, and 20% of the vari ability could be used as a clinically convenient threshold to qualitatively classify patients into high- and low-variability groups. The current study is important for identifying high-risk populations and for long-term disease management. (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 25, 2022 Category: Opthalmology Source Type: research
