Topographic Differences in Superficial Macular Vessel Density in Eyes with Early Primary Open-Angle Glaucoma and Normal Tension Glaucoma

Introduction: To compare macular vascular microcirculation in early primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), and normal subjects. Methods: 99 patients with early glaucoma (99 eyes: 60 POAG and 39 NTG) and 78 normal subjects were included. All subjects underwent optical coherence tomography angiography (OCTA) scan at 6 ×6 mm macular area. Macular vessel density (VD) and perfusion density (PD) and 9 sectors were compared between the controls, POAG and NTG groups. Linear regression analysis was used to investigate the relationship between VD and other variables including macular PD, signal strength (SS) and mean ma cular ganglion cell-inner plexiform layer (mGCIPL) thickness. Results. Significant losses in total area of VD and PD were detected in POAG and NTG groups compared to the controls (all P0.05). Except for outer-nasal sector, all other outer sectors of macular VD and PD were significant lower in POAG than in the controls (all P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research