Comparative study of Curcumin and Lucentis on retinal neovascularization
Introduction To investigate the effect of Curcumin on retinal neovascularization in mice with oxygen-induced lesions.
Methods 7-day-old (P7) C57/BL6J mice were randomly divided into control group, OIR group, DMSO group, 100 mg/kg, 50 mg/kg and 25 mg/kg curcumin group and Lucentis group (15 mice per group). Mice in the experimental group were fed for 5 days in high oxygen partial pressure environment, and then in normal oxygen air environment for another 5 days. Corresponding interventions were given at 12-16 days of age (P12-16). At 17 days of age (P17), the eyeball was removed and the retina was paved with Isolectin GS-I...
Source: Ophthalmic Research - November 21, 2022 Category: Opthalmology Source Type: research
Changes of Choroidal Thickness in Children after Short-erm Application of 1% Atropine Gel
Introduction: To assess changes of choroidal thickness (ChT) after administration of 1% atropine for 1 week in myopia, emmetropia, and hyperopia children.
Methods: A total of 235 children aged 4 –8 years, which included 46 myopia, 34 emmetropia, and 155 hyperopia patients were recruited and divided into three groups according to the spherical equivalent with the use of 1% atropine twice a day for 1 week. The ChT was measured at baseline and 1 week.
Results: In the myopia and emmetropia gr oups, following administration of 1% atropine gel, the ChT thickened significantly under the fovea (i.e., from 278.29 ± 53.01 μm to...
Source: Ophthalmic Research - November 21, 2022 Category: Opthalmology Source Type: research
Early Retinal Microvasculopathy in Prediabetic Patients and Correlated Factors
Introduction: We aimed to detect early retinal microcirculation changes in prediabetic patients and investigate their correlation with clinical examinations.
Methods: Forty-seven prediabetic individuals, 29 controls, and 81 type 2 diabetic mellitus (T2DM) patients were enrolled in this study. A review of clinical data and spectral-domain optical coherence tomography angiography (SD-OCTA) parameters of macular vessel diameter (VD), foveal avascular zone (FAZ), and macular vessel area density (VAD) was performed.
Results: Levels of low-density lipoprotein cholesterol and triglycerides in prediabetes and T2DM groups were si...
Source: Ophthalmic Research - November 16, 2022 Category: Opthalmology Source Type: research
A Novel and Reversible Experimental Primate Ocular Hypertension Model: Blocking Schlemm ’s Canal
Introduction: The purpose of this study was to establish a novel and reversible experimental ocular hypertension primate model by blocking Schlemm ’s canal.
Methods: A model was induced in adult cynomolgus monkeys (n=4) by blocking Schlemm’s canal with an inserted microcatheter (200 μm diameter); it was removed 6 weeks later from one monkey to reverse the elevated intraocular hypertension. All animals were monitored for 11 months; weekly measurements of intraocular pressure and biweekly examinations with spectral domain optical coherence tomography and disc photography were performed. Histopathology of the eye and re...
Source: Ophthalmic Research - November 15, 2022 Category: Opthalmology Source Type: research
Faster Macular Vessel Density Loss in More Advanced Primary Open Angle Glaucoma Eyes
Conclusions: OCTA measurements could detect vascular deterioration over time in POAG eyes at different stages. The rates of macular VD loss were significantly faster in more advanced POAG eyes. (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 15, 2022 Category: Opthalmology Source Type: research
High-frequency deep sclerotomy as adjunctive therapy in open angle glaucoma patients
Conclusion: This study presents the data on our first surgical experience with high-frequency deep sclerotomy that was conducted on 23 patients who had medically-uncontrolled, primary, open-angle glaucoma. The results indicate that HFDS is safe and efficient in reducing IOP. (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 14, 2022 Category: Opthalmology Source Type: research
Relationships between cataract surgery patient-perceived discharge teaching quality, discharge readiness, and post-discharge outcomes: a cross-sectional study based on regression modeling analysis
Conclusions: The effect of discharge planning services on patients undergoing cataract surgery was generally satisfactory. High-quality discharge teaching can enhance patients’ discharge readiness, further impr oving their post-discharge outcomes. When conducting discharge teaching, day ward medical staff should pay more attention to patients’ demands and explore a more effective teaching delivery method. (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 9, 2022 Category: Opthalmology Source Type: research
Fusional vergence dysfunctions in acute acquired concomitant esotropia of adulthood with myopia
Introduction: Acute acquired concomitant esotropia (AACE) has been increased dramatically in myopia. To clarify whether fusional vergence dysfunctions exist in AACE with myopia, and to explore the relationship between fusional vergence and myopia in AACE
Methods: A prospective clinical study. Adult AACE patients as well as controls (aged ≥18 years) both with myopia were prospectively recruited from October 2016 to August 2021. Refractive error and fusional divergence and convergence amplitude at distance were measured, as determined with a comprehensive refractor. The main outcome measures were the real value of the fus...
Source: Ophthalmic Research - November 7, 2022 Category: Opthalmology Source Type: research
Erratum
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 3, 2022 Category: Opthalmology Source Type: research
Immediate effect in retina and choroid after 650 nm low-level red light therapy in children
Introduction: To investigate the changes in the retina and choroid of children after 650 nm low-level red light therapy (LLRLT).
Methods: In this prospective study, 25 subjects in the Shanghai Eye and ENT Hospital of Fudan University were included from August 2021 to September 2021. One eye was randomly selected to receive LLRLT for 3 minutes. Swept-source optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure retinal fovea perfusion density (RFPD), retinal fovea thickness (RFT), choroidal fovea blood flow (CFBF), and choroidal fovea thickness (CFT) before LLRLT, 5 minutes and 1 hour after LLRL...
Source: Ophthalmic Research - October 31, 2022 Category: Opthalmology Source Type: research
High Levels of Heat Shock Protein 47 in the Aqueous Humor of Patients with Acute Primary Angle Closure
Conclusion: HSP47 was upregulated in the aqueous humor of patients with APAC and may play a role in scarring after trabeculectomy for APAC. (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 31, 2022 Category: Opthalmology Source Type: research
Differences in inferior oblique muscle satellite cell populations between primary and secondary inferior oblique muscle overaction
Introduction: To compare the number of paired box 7 (PAX7)-positive, myogenic differentiation 1 (MyoD1)-positive, and neural cell adhesion molecule-1 (NCAM)-positive satellite cells in human primary vs. secondary inferior oblique muscle overaction (IOOA).
Methods: This prospective observational study enrolled patients who underwent inferior oblique muscle myectomy at the Department of Pediatric Ophthalmology and Strabismus in Tianjin Eye Hospital between January 2020 and November 2020. The muscle specimens were processed. Immunohistochemistry and immunofluorescence were used to quantify inferior oblique muscle fiber diame...
Source: Ophthalmic Research - October 27, 2022 Category: Opthalmology Source Type: research
Hospital-based study of risk factors associated with development of myopic macular neovascularization in highly myopic eyes
Introduction: Myopic macular neovascularization (MNV) is the most common cause of a reduction of central vision in eyes with pathologic myopia, and it can progress to macular atrophy in the long-term. The aim of this study was to determine the risk factors associated with the development of MNVs.
Methods: There were 17,198 follow-up records from 5,409 eyes of 2,784 highly myopic patients that were reviewed. The general information and ophthalmic information in the records were studied. The significance of the correlations of factors associated with the development and predicting the development of myopic MNV were determin...
Source: Ophthalmic Research - October 19, 2022 Category: Opthalmology Source Type: research
Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population
Conclusions: High PA level, particularly recreational PA, was associated with smaller FAZ and greater VD and PD in senior adults. Non-leisure time PA might not confer the same health benefits as leisure time PA. Our data su pports a possible protective role of recreational PA in the retina against microvascular changes. (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 17, 2022 Category: Opthalmology Source Type: research
Effects of Androgen Deprivation Therapy on the Extraocular Muscles, Retrobulbar Orbital Fat and the Optic Nerve in Patients with Prostate Cancer
Introduction: To evaluate radiologically the effects of long-term Luteinizing hormone-releasing hormone (LHRH) agonist therapy on extraocular muscle thickness, retrobulbar orbital fat (ROF), and optic nerve (ON) in prostate cancer (PCa) patients.
Methods: This retrospective study included patients with primary or recurrent PCa who received androgen deprivation therapy (ADT) for at least 12 months. Each patient underwentallium-68 prostate-specific membrane antigen positron emission tomography-computed tomography (Ga-68 PSMA PET/CT) both before and at the end of the 12-month treatment. Thickness of the ON, lateral rectus mu...
Source: Ophthalmic Research - October 13, 2022 Category: Opthalmology Source Type: research
