Characteristics of the Filtering Bleb and the Agreement between Glaucoma Specialist and Anterior Segment OCT Assessment
Conclusion: There is fair agreement between glaucoma specialist assessment and AS OCT assessment in terms of the presence of f luid in trabeculectomy. Our findings highlight the importance of AS OCT in some patients before deciding upon a new intervention. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 16, 2020 Category: Opthalmology Source Type: research
Longitudinal retinal changes induced by hydroxychloroquine in eyes without retinal toxicity
Conclusion: Hydroxychloroquine was found to cause progressive thinning of the inner retinal layers, specifically in the GCL of the foveolar and par acentral areas, but no changes were observed in the outer retina. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 14, 2020 Category: Opthalmology Source Type: research
Real-world outcomes after 36 months treatment with ranibizumab 0.5 mg in patients with visual impairment due to diabetic macular edema (BOREAL-DME)
Purpose:
To assess the efficacy, safety and follow-up of 36 months treatment with ranibizumab in patients with diabetic macular edema (DME) in real life setting.
Methods
This is a prospective phase 4 observational study. Between December 2013 and April 2015, 84 ophthalmologists enrolled a total of 290 adult patients initiating ranibizumab for visual impairment due to diabetic macular edema (DME) and treated them according to their routine practice. The primary outcome (mean change in best-corrected visual acuity [BCVA] after 12 months) was previously reported. Here we present outcomes after 36 months of follow-up for BC...
Source: Ophthalmic Research - September 14, 2020 Category: Opthalmology Source Type: research
Effectiveness of iStent trabecular micro-bypass system combined with phacoemulsification vs. phacoemulsification alone in patients with glaucoma and cataract depending on the initial intraocular pressure
INTRODUCTION: To assess the effect of iStent trabecular micro-bypass implantation combined with phacoemulsification on intraocular pressure (IOP) and glaucoma medications, and to compare this to outcomes of phacoemulsification alone in patients with mild to moderate primary open-angle glaucoma (POAG) depending on initial IOP.
MATERIAL AND METHODS: 80 subjects with cataract and POAG were randomized 1:1 to either iStent implantation and cataract surgery (iStent group) (n=44) or cataract surgery alone (control group) (n=36). Groups were divided according to initial IOP (after wash out period) into IOP (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 8, 2020 Category: Opthalmology Source Type: research
Comparison of the Icare ic100 rebound tonometer and the Goldmann applanation tonometer in 1000 eyes
The objective was to compare IOP measured using Icare ic100 and GAT.
Methods
This cross-sectional study measured IOP in1000 eyes (500 left, 500 right) using the ic100 and GAT. Central cornel thickness (CCT) was measured using a handheld pachymeter. IOP measurements were investigated in all eyes, by IOP sub-strata by CCT group, by number of topical glaucoma medications and diagnosis.
Results
There was moderate agreement between ic100 and GAT IOP measurements (intraclass correlation coefficient .73). Mean IOP was significantly lower measured by ic100 compared to GAT (12.1mmHg vs. 16.2mmHg, p (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 8, 2020 Category: Opthalmology Source Type: research
The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population
Conclusions: The SNP rs4148568 and a haplotype TCGGAG in ABCC5 contribute to PACG in northern Chinese people. In addition, rs4148568 might be associated with the AL and the variant allele of which may have effect of making the AL longer. Further studies are needed to elucidate the exact mechanism of ABCC5 in the progress of PACG. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 8, 2020 Category: Opthalmology Source Type: research
Association of VEGF gene family variants with central macular thickness and visual acuity after Aflibercept short-term treatment in diabetic patients: A pilot study
Introduction: Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. Objective: This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene family and related receptor variants (rs833069, rs12366035, rs7664413, rs7993418, and rs2305948) with susceptibility of diabetic retinopathy (DR) and the response to one dose of aflibercept treatment in type 2 diabetes mellitus (T2DM). Methods: Consecutive eligible patients with T2DM (n=125) and 110 unrelated ...
Source: Ophthalmic Research - August 23, 2020 Category: Opthalmology Source Type: research
Clinical outcomes of endoscope-assisted 30-gauge single-needle technique for intrascleral intraocular lens fixation
Conclusions:
The endoscope-assisted single needle technique is a safe and effective method of intrascleral IOL fixation surgery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 20, 2020 Category: Opthalmology Source Type: research
Evaluation of refractive status and ocular biometric parameters in primary angle closure disease.
Introduction: To evaluate the refractive status and ocular biometric parameters in subjects with angle-closure in Malaysia.
Methods: This cross-sectional study was conducted on 171 primary angle closure patients (268 eyes). Visual acuity, refraction and ocular biometry (central anterior chamber depth (ACD), axial length (AXL), and lens thickness) were recorded. Vitreous cavity length and relative lens position (RLP) were calculated.
Results: A total of 92 Primary Angle Closure Suspect (PACS), 30 Primary Angle Closure (PAC), and 146 Primary Angle Closure Glaucoma (PACG) eyes were included. Chinese ethnicity formed the maj...
Source: Ophthalmic Research - August 17, 2020 Category: Opthalmology Source Type: research
Automatic Classification of Anterior Chamber Angle Based on Ultrasound Biomicroscopy Images
Conclusions: Our method of automatic angle localization and classification based on UBM images is feasible and reliable. The automatic classification of ACA provides a basis and reference for future studies. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 17, 2020 Category: Opthalmology Source Type: research
Combined Orthokeratology with Atropine for children with Myopia: A Meta-analysis
Conclusion: Our study suggests that the combination of OK and 0.01% atropine is more effective in slowing axial elongation than OK monotherapy in children with myopia in a relatively short duration of treatment. In addition, the combination therapy has no negative influence on uncorrected distant visual acuity, corneal endothelial cell density, and intraocular pressure. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 10, 2020 Category: Opthalmology Source Type: research
Asthma Promotes Choroidal Neovascularization via the Transforming Growth Factor beta1/Smad Signaling Pathway in a Mouse Model
Conclusion: We provide new evidence that asthma could be a risk factor for CNV development via the TGF-β1/Smad signalling pathway. A TGF-β inhibitor can be applied as a useful, adjunctive therapeutic strategy for preventing CNV formation in asthmatic patients. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 10, 2020 Category: Opthalmology Source Type: research
Quantitative analysis of perfusion characteristics using contrast-enhanced ultrasound in patients with choroidal metastasis
Purpose: To quantitatively analyze the perfusion characteristics of choroidal metastasis using contrast-enhanced ultrasound (CEUS), and compare its perfusion characteristics with these of choroidal hemangioma and choroidal melanoma. Methods: The patients who were clinically diagnosed as choroidal metastasis were recruited as the study group and the patients who were diagnosed as choroidal hemangioma and choroidal melanoma during the same period were included as the comparison group. All patients underwent CEUS examination, and Sonoliver was used to obtain the data on quantitative parameters of the tumor and the adjacent no...
Source: Ophthalmic Research - August 10, 2020 Category: Opthalmology Source Type: research
Interocular Asymmetry of Visual Field Loss, Intraocular Pressure and Corneal Parameters in Primary Open-angle Glaucoma
Objectives: To assess the association between the corneal biomechanical parameters and visual field (VF) loss in patients with asymmetric primary open-angle glaucoma (POAG).
Methods: A total of 89 POAG patients (50 males, 56.2%) with asymmetric VF loss, aged 65.2 ± 13.3 years old, were enrolled in this study. Asymmetric VF loss was defined as an interocular difference of the global index mean deviation (MD)>2dB. Intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters such as maximum amplitude at the apex of highest concavity (Def ampl HC) were measured. The worse eye was defined a...
Source: Ophthalmic Research - August 5, 2020 Category: Opthalmology Source Type: research
Choroidal Thickness Changes After Orthokeratology Lens Wearing in Young Adults with Myopia
Conclusions: In the beginning of orthokeratology treatment, choroidal thickness of the horizontal axis was 248.9 ± 45.7 µm in the temporal regio n, 259.9 ± 55.3 µm in the macular region, and 219.2 ± 46.4 µm in the nasal region. Three months after orthokeratology treatment, thickness values of choroids in the three divided areas increased significantly (P (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 5, 2020 Category: Opthalmology Source Type: research
