IOL formula constants – strategies for optimization and defining standards for presenting data
Conclusions: Different constant optimization concepts yield different results. To test the performance of optimized formula constants a cross-validation strategy is mandatory. We recommend performance curves, where the ratio of cases within absolute prediction error limits is plotted against the mean absolute prediction error. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 1, 2021 Category: Opthalmology Source Type: research
Dysregulation of miR-637 is involved in the development of retinopathy in hypertension patients and serves a regulatory role in retinol endothelial cell proliferation
Conclusion: Our data indicate that miR-637 is a potential non-invasive marker for patients with HR. The action of miR-637 on STAT3 may inhibit the proliferation and migration of retinal endothelial cells, providing a possible target for the treatment of HR. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 1, 2021 Category: Opthalmology Source Type: research
Role of Oxidative Stress and Severity of Diabetic Retinopathy in Type 1 and Type 2 Diabetes
Background: Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR.
Objectives : To evaluate the status of antioxidant enzymes -superoxide dismutase (SOD) and catalase (CAT); with different stages of DR severity in subjects with type 1 and type 2 DM.
Methods: The cross-sectional study enrolled 148 subjects with type 1 DM (n=17); type 2 DM (n=96) and non-diabetes controls (n=35). Subjects with DM were divided into two subgroups based on DR severity (mild-to-severe non-proliferative ...
Source: Ophthalmic Research - January 25, 2021 Category: Opthalmology Source Type: research
Role of Oxidative Stress and Severity of Diabetic Retinopathy in Type 1 & Type 2 Diabetes
Background: Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus (DM). Oxidative stress generated on account of hyperglycemic state may lead to retinal abnormalities including DR.
Objectives : To evaluate the status of antioxidant enzymes -superoxide dismutase (SOD) and catalase (CAT); with different stages of DR severity in subjects with type 1 and type 2 DM.
Methods: The cross-sectional study enrolled 148 subjects with type 1 DM (n=17); type 2 DM (n=96) and non-diabetes controls (n=35). Subjects with DM were divided into two subgroups based on DR severity (mild-to-severe non-proliferative ...
Source: Ophthalmic Research - January 25, 2021 Category: Opthalmology Source Type: research
Predictors for 2-year functional and morphological outcomes of a treat and extend regimen with ranibizumab in patients with diabetic macular edema
Abstract
Purpose: To investigate longer-term functional and morphological outcomes and their predictors in diabetic macular edema (DME) following a treat and extend regimen (TER) without loading dose under ranibizumab.
Methods: Patient data were reviewed and analyzed retrospectively over a period of 24 mo nths after initiation of TER. Best-corrected visual acuity (BCVA), treatment frequency as well as quantitative and qualitative Spectral-domain Optical Coherence Tomography parameters were assessed.
Results: 118 eyes of 87 patients were included. A mean of 9.742.13 injections in the first and 7. 632.29 in the se...
Source: Ophthalmic Research - January 25, 2021 Category: Opthalmology Source Type: research
Ocular pathology and occasionally detectable intraocular SARS-CoV-2 RNA in five fatal COVID-19 cases
Conclusion
As already described in other organs of COVID-19 patients, the ophthalmological examination revealed-microthrombi, i.e. hypercoagulation and vasculopathy most probably due to endothelial damage. A possible viral spread to the endothelial cells via ACE-2 provides one pathophysiological explanation. The expression of ACE-2 receptors in the conjunctiva hints towards its susceptibility to infection. To what extend eyes function are disrupted by SARS-CoV-2 is subject to further studies, especially in the clinic. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 19, 2021 Category: Opthalmology Source Type: research
Current management of Inherited Retinal Degenerations (IRD) patients in Europe. Results of a multinational survey by the European Vision Institute Clinical Research Network EVICR.net
Purpose: An increasing number of gene therapies are developed for Inherited Retinal Degenerations (IRD). To date, one treatment has been approved for clinical use (FDA USA 2017, EMA Europe 2018, MoHAP UAE 2019, SFDA Saudi Arabia 2019, Swiss Medic Switzerland 2020, TGA Australia 2020, BFR Brazil 2020). Whilst such therapies do not provide complete cure, they may halt degeneration or partially restore function. Identification of well-characterized patients is an emerging need. We conducted the first multinational survey to understand the management of IRDs in Europe.
Methods: An electronic survey questionnaire containing 11...
Source: Ophthalmic Research - January 18, 2021 Category: Opthalmology Source Type: research
Retinal vascular fractal dimensions and their association with macrovascular cardiac disease.
Conclusions
This study demonstrates that lower complexity of main venular vessels associates with higher risk of having CABG. The research supports the hypothesis that the retinal vascular structure can be used to assess non-ocular macrovascular disease. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 14, 2021 Category: Opthalmology Source Type: research
Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review
Retinal ganglion cells (RGC) play a crucial role in the visual pathway. As their axons form the optic nerve, apoptosis of these cells causes neurodegenerative vision loss. RGC death could be triggered by increased intraocular pressure, advanced glycation end products, or mitochondrial dysfunction. In this review, we summarize the role of some neuroprotective factors in RGC injury: ciliary neurotrophic factor (CNTF), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glial cell line-derived neurotrophic factor (GDNF), and ...
Source: Ophthalmic Research - January 14, 2021 Category: Opthalmology Source Type: research
Myopic retinal changes screening: comparison of sensitivity and specificity among 15 combinations of ultrawide field scanning laser ophthalmoscopy images
Conclusion: In our study, screening combinations of B+S+I, B+T+S+I and B+S+N+I stand out with high-performing optimal evaluation indices. However, when time is limited, B+S+I may be more applicable in primary screening of MRC. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 4, 2021 Category: Opthalmology Source Type: research
Transient Alteration of Retinal Microvasculature after Refractive Surgery
Conclusion: The transient alteration of the retinal microvasculature after refractive surgery appeared to recover quickly, which may not impact the visual function after FS-LASIK.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 16, 2020 Category: Opthalmology Source Type: research
The predictive value of interleukin-8 in the development of cytomegalovirus retinitis in HIV-negative patients
Conclusion:
In HIV-negative patients with CMVR, IL-8 was closely associated with CMV DNA concentration in the aqueous humor. The real-time aqueous level of IL-8 could be used as one of the evidences of disease recovery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 15, 2020 Category: Opthalmology Source Type: research
Clinical and surgical outcome of a supplementary multifocal intraocular lens implanted with a bag-in-the-lens IOL: 5-year follow up
Conclusion: Patients with a multifocal sIOL in combination with a bag-in-the-lens implantation have a higher incidence of dysphotopsia compared to previously published studies. Dysphotopsia was the main complaint and reason for explantation. We encountered a high incidence of pigmented IOL deposits. The sIOLs can be safely removed even years after implantation. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 15, 2020 Category: Opthalmology Source Type: research
Contents, Vol. 63, 2020
Ophthalmic Res 2020;63:I –VI (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 15, 2020 Category: Opthalmology Source Type: research
Acknowledgement to Reviewers
Ophthalmic Res 2020;63:593 –594 (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 15, 2020 Category: Opthalmology Source Type: research
