Efficacy and Safety of Different Add Power Soft Contact Lenses on Myopia Progression in Children ：A systematic review and meta-analysis
Conclusions: The present meta-analysis showed that high add power SMCLs are more effective and stable to control myopia progression. Besides, the adverse effects and acceptability were not related to the added power. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 28, 2022 Category: Opthalmology Source Type: research
Distribution, Progression, and Associated Factors of Refractive Status of Children in Lhasa, Tibet, after COVID-19 Quarantine
Conclusion: This study found that after the COVID-19 confinement, myopia progressed faster in Lhasa children but was still significantly lower than that of plain cities in China. Compared to short-term confinement, this acceleration was more likely related to the growth and general trend of myopia in children. Collectively, these findings help to explore the differences in ocular growth and development among children of different ethnic groups.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 16, 2022 Category: Opthalmology Source Type: research
Distribution, Progression, and Associated Factors of Refractive status of Children in Lhasa, Tibet after COVID-19 Quarantine
Conclusion
This study found that after the COVID-19 confinement, myopia progressed faster in Lhasa children but was still significantly lo wer than that of plain cities in China. Compared to short-term confinement, this acceleration was more likely related to the growth and general trend of myopia in children. Collectively, these findings help to explore the differences in ocular growth and development among children of different ethni c groups. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 16, 2022 Category: Opthalmology Source Type: research
MiRNA-21- HIF-1 α-VEGF Axis is Associated with Myopic Choroidal Neovascularization in Guinea Pigs
Conclusion: miR-21 correlated with HIF-1α-VEGF signaling pathway may promote CNV formation in high-myopia guinea. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 14, 2022 Category: Opthalmology Source Type: research
Impact of decentration and tilt on spherical, aberration correcting and specific aspherical intraocular lenses; an optical bench analysis.
Conclusion:
Aberration correcting IOLs perform best when perfectly centered. The optical performance of aberration correcting IOLs can be markedly downgraded by misalignment. The examined ZO optic performed well in decentration and tilt. The ZO concept seems to be a good alternative to aspheric lenses, as it achieves to combine benefits of spherical and aspheric intraocular lenses. There is no perfect IOL, but fitting and choosing the right one for the individual case seems to be crucial to take advantage of benefits and minimize disadvantages. This is why k nowledge of optical properties is also mandatory for the surgeon....
Source: Ophthalmic Research - February 10, 2022 Category: Opthalmology Source Type: research
Correlation between serum cystatin C level and retinal blood flow in patients with essential hypertension
This study aimed to detect the blood flow in the optic disc and macula in patients with essential hypertension and to analyze its correlation with serum cystatin C (Cys-C) levels.
Methods: This single center, cross-sectional study included 100 patients with primary hypertension without hypertensive retinopathy, who were divided into an experimental group (50 cases, 50 eyes) with elevated serum Cys-C levels and a control group (50 cases, 50 eyes) with normal serum Cys-C . The optic disc and macular vessel density (VD) and vascular perfusion density (PD) were assessed using optical coherence tomography angiography (OCTA). D...
Source: Ophthalmic Research - February 9, 2022 Category: Opthalmology Source Type: research
Meta-analysis of the genetic association between PTPN22, CTLA-4 variants and risk of uveitis
Background: Though the risk of PTPN22, CTLA-4 genetic variants with uveitis have been developed, the combined results still remain uncertain and controversial. Objectives: To perform a meta-analysis to estimate the precise association of PTPN22 (rs2488457, rs2476601) and CTLA-4 (rs231775, rs5742909, rs4553808, and rs3087243) polymorphisms with uveitis susceptibility. Method: Five electronic databases (PubMed, Embase, Web of Science, CBM, CNKI) were systematically searched for relevant literature up to July 20, 2021. All statistical analysis were evaluated by STATA 12.0 software and R programming language. Results: Our meta...
Source: Ophthalmic Research - February 7, 2022 Category: Opthalmology Source Type: research
Baseline Levels of Retinol Binding Protein 4 and Vitamin A in Healthy Subjects, Stargardt Disease and Geographic Atrophy Patients
Conclusion: Serum RBP4 and SR do not appear to be affected by age in healthy individuals and remain within normal limits in both STGD1 and GA. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 2, 2022 Category: Opthalmology Source Type: research
Changes in ganglion cell layer thickness after treatment with the 0.2 µg/day fluocinolone acetonide implant in vitrectomized and nonvitrectomized eyes with diabetic macular edema
Conclusion: There was no evident retinal neurodegeneration in the 2-year period following treatment with FAc in both groups. GCL thickness may be a useful biomarker for assessing safety and effectiveness in patients with DME. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 27, 2022 Category: Opthalmology Source Type: research
Calculation of equivalent and toric power in AddOn lenses based on a Monte Carlo simulation
Conclusion: Our simulation shows that with a linear model the equivalent and toric AddOn power as well as overall change in magnification, meridional distortion before and after AddOn implantation as well as the reduction in meridional dist ortion can be easily predicted from the biometric data in pseudophakic eyes with moderate refractive error. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 17, 2022 Category: Opthalmology Source Type: research
< b > < i > Borrelia < /i > < /b > Ocular Infection: A Case Report and a Systematic Review of Published Cases
Conclusion: This systematic review, including all reported cases and our case report, supports evidence of ocular infection ofBorrelia species. Furthermore, in case of suspicion of infection and seronegativity, it is justified to look forBorrelia in eye tissue samples. In addition, microscopy without using PCR is not sufficient to confirm the diagnosis of borreliosis on ocular tissue. In the articles studied, there was no unambiguous recommendation of treatment.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 14, 2022 Category: Opthalmology Source Type: research
Advances in the genetics of congenital ptosis
Congenital ptosis, a birth defects presents at birth or by 1 year of age, is characterized by the drooping of the upper eyelid. either in isolation (non-syndromic) or with many different systemic disorders (syndromic). The estimated prevalence of ptosis (congenital acquired) ranges from 0.79 to 1.99 per 10,000 people in different populations, and it is more prevalent in males. The underlying pathogenesis of congenital ptosis are myogenic and neurogenic, related to the development of muscles and nerves. Although most cases are sporadic, there are familial transmission characteristics, including autosomal dominant, recessive...
Source: Ophthalmic Research - December 30, 2021 Category: Opthalmology Source Type: research
MicroRNA-Expression Profiling in Myopia: A Meta-Analysis and Systematic Review
Conclusions: Our meta-analysis recommends several miRNAs may provide some clues of the potential biomarkers in myopia. Further mechanistic studies are warranted to elucidate the biological role of the dysregulated miRNAs in the development of myopia. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 27, 2021 Category: Opthalmology Source Type: research
MicroRNA expression profiling in myopia: a meta-analysis and systematic review
Conclusions. Our meta-analysis recommends several miRNAs may provide some clues of the potential biomarkers in myopia. Further mechanistic studies are warranted to elucidate the biological role of the dysregulated miRNAs in the development of myopia. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 27, 2021 Category: Opthalmology Source Type: research
Intravitreal injection is associated with increased posterior capsule rupture risk during cataract surgery: A meta-analysis
Conclusion: This meta-analysis provides e vidence that previous IVI significantly increases the risk of PCR during future cataract surgery. The risk of PCR should be discussed preoperatively with patients. Further studies are required to validate our findings and explore the underlying mechanisms. (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 23, 2021 Category: Opthalmology Source Type: research
