Morphological changes and potential mechanisms of intraocular pressure reduction after micropulse transscleral cyclophotocoagulation in rabbits
Conclusion: A potential mechanism for IOP reduction in pigmented rabbits is aqueou s humor transport dysfunction due to damage to the nonpigmented epithelial cells of the pars plicata and destruction of basal infoldings. The power of MP-TSCPC was consistent with both morphological changes and IOP reduction. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 30, 2020 Category: Opthalmology Source Type: research
Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma
Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma.
Methods: In this cross-sectional study, 102 eyes from 102 patients with advanced glaucoma (defined as a 24-2 VF mean deviation (MD) ≤ -12 dB) were included. mGCIPLT, cpRNFLT and ONH parameters (including the rim area, average cup-to-disc (C:D) ratio and vertical C:D ratio) were measured using Cirrus high-definition OCT ...
Source: Ophthalmic Research - July 29, 2020 Category: Opthalmology Source Type: research
Growth Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration: A Meta-analysis of Natural History Studies and Implications for Designing Future Trials
Introduction: There is no effective treatment for geographic atrophy (GA). To help design future GA treatment trials, we conducted a meta-analysis for GA growth rate and its variability in natural history studies.
Methods: Literatures were searched up to April 30, 2020. Data were extracted independently by 2 authors and analyzed using random-effects models.
Results: The pooled mean GA growth rate was 1.66 mm2/year (SD=1.27 mm2/year, I2=97.0%, p (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 27, 2020 Category: Opthalmology Source Type: research
The Role of Gut Microbiome in Autoimmune Uveitis
The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review summarizes recent literature regarding the relationship between dysbiosis and the occurrence and development of autoimmune uveitis. Dysbiosis participates in the pathogenesis of autoimmune uveitis largely by four mechanisms: antigenic mimicry, disturbance of intestinal immune homeostasis, destruction of the in...
Source: Ophthalmic Research - July 15, 2020 Category: Opthalmology Source Type: research
Tear 1H NMR-based metabolomics application to the molecular diagnosis of aqueous tear deficiency and Meibomian gland dysfunction
Conclusions: Our key distinctive findings support that DE-MGD induces tear metabolomics profile changes. Metabolites contributing to a higher separation from the CG can presumably be used, in the foreseeable future, as DE-MGD biomarkers for better managing the diagnosis and therapy of this disease. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 15, 2020 Category: Opthalmology Source Type: research
