Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma

Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma. Methods: In this cross-sectional study, 102 eyes from 102 patients with advanced glaucoma (defined as a 24-2 VF mean deviation (MD) ≤ -12 dB) were included. mGCIPLT, cpRNFLT and ONH parameters (including the rim area, average cup-to-disc (C:D) ratio and vertical C:D ratio) were measured using Cirrus high-definition OCT (HD-OCT), and 24-2 and 10-2 VF sensitivity tests were performed using standard automated perimetry (SAP). Pea rson correlations and linear models were used to analyse relationships between OCT-derived parameters and VF parameters. Results: The mGCIPLT and rim area were significantly positively correlated with the 24-2 VF MD, 24-2 VF pattern standard deviation (PSD), 24-2 VF visual field index (VFI) and 10-2 VF MD, but cpRNFLT was not significantly correlated with VF parameters. Additionally, the average and vertical C:D ratios were significantly negatively correlated with VF parameters. The mGCIPLT and rim area were significantly positively correlated with the 10-2 VF MD (r ranging between 0.542 and 0 .621, P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research