Long-term outcomes of high-dose conbercept treatment for myopic cho-roidal neovascularisation and idiopathic choroidal neovascularisation
Introduction: To report 2-year outcomes of intravitreal injection of high-dose conbercept (1 mg 2+PRN scheme) for subjects with myopic choroidal neovascularization (mCNV) and idiopathic choroidal neovascularization (iCNV) by optical coherence tomography angi-ography (OCTA) follow-up. Methods: A total of 38 subjects (38 eyes) were enrolled in this retrospective study, which were divided into group A (mCNV, 20 subjects, 20 eyes) and group B (iCNV, 18 subjects,18 eyes). All subjects received 1.0 mg of conbercept intravitre-ally at diagnosis and again 35 days later. Additional conbercept injection was administered upon finding...
Source: Ophthalmic Research - February 6, 2023 Category: Opthalmology Source Type: research

Repositioning of in-the-bag Dislocated Intraocular Lenses: A Randomized Clinical Trial Comparing Two Surgical Methods
Conclusion: After IOL fixation surgery, IOL tilt is higher than in normal pseudophakia. A study involving more patients without capsular fibrosis could clarify whether IOL position is better with method B in this subgroup. IAA is low, but myopic shift is common. AS-OCT is useful for IOL tilt assessment after IOL fixation surgery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 3, 2023 Category: Opthalmology Source Type: research

Repositioning of In-the-Bag Dislocated Intraocular Lenses. A Randomized Clinical Trial Comparing Two Surgical Methods
Introduction: To evaluate IOL tilt, IOL-induced astigmatism (IIA), refractive change and impact of capsular fibrosis on IOL position after scleral fixation of dislocated IOL using two methods: Ab Externo Scleral Suture Loop Fixation (Group A) and a modification, Embracing the Continuous Curvilinear Capsulorhexis (Group B). Methods: In this prospective randomized clinical trial conducted at St. Erik Eye Hospital, 117 patients with dislocated IOL were randomized to Group A (n = 61) or B (n = 56). Patients with ordinary pseudophakia (n = 60) served as controls. IOL tilt was measured three-dimensionally with anterior segm...
Source: Ophthalmic Research - February 3, 2023 Category: Opthalmology Source Type: research

Internal limiting membrane peeling or inverted flap technique combined with air tamponade in the treatment of macular holes in high myopia
Purpose :To analyze the anatomical and visual outcomes after internal limiting membrane (ILM) peeling or ILM flap insertion in highly myopic macular holes (HMMHs), and try to compare these two surgical techniques in large HMMHs. Methods:This is a retrospective, consecutive series study of patients with HMMH undergone vitrectomy from September 2016 to January 2021. We observed the outcomes of the HMMHs with ILM peeling and ILM flap insertion, respectively. Binary logistic regression and receiver operating characteristic (ROC) curve were used to analyze the relationship between the minimum linear di ameter (MLD) of macul...
Source: Ophthalmic Research - February 3, 2023 Category: Opthalmology Source Type: research

Macular Choroidal Thickness and Choriocapillaris Vessel Density Alterations in Type 2 Diabetics with High Myopia
Introduction: The purpose of this study was to investigate the change of macular choroidal thickness and choriocapillaris vessel density in type 2 diabetic with high myopia. Methods: This cross-sectional study recruited a total of 182 patients (182 eyes) in the Affiliated Hospital of Chengde Medical University between January 2018 and December 2021, including myopia+diabetes patients (40 eyes), T2D patients without myopia patients (47 eyes), myopia patients (45 eyes) and healthy volunteers (50 eyes). The choroidal thickness and choriocapillaris vessel density of macular were measured in all subjects by optical coherence to...
Source: Ophthalmic Research - February 2, 2023 Category: Opthalmology Source Type: research

Optical Quality Variation Of Different Intraocular Lens Designs In A Model Eye: Lens Placed Correctly And In An Upside-Down Position.
Conclusion: The aberration-free IOL is the best choice when minimal postoperative errors of decentration or tilt are predicted. With IOL flip, the negative SA lens design is the best choice, regarding the root mean square wavefront aberrations. However, in a proper IOL implantation, the IOL designed to partially compensate the corneal SA including asphericity on its posterior surface is the better possible option, even in the presence of decentration or tilt. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 30, 2023 Category: Opthalmology Source Type: research

Morphological characteristics of foveal pit base and its impact on visual acuity in macular pseudoholes
Conclusion: The v-shape, reflecting the stretch in the foveola, had a significant impact on preoperative BCVA. However, the VA was improved after surgery whatever their initial foveal profile. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 30, 2023 Category: Opthalmology Source Type: research

Comparison of Chorioretinal Parameters in Diabetic Retinopathy with or without Pan-retinal Photocoagulation Using Ultrawide-field Swept Source Optical Coherence Tomography Angiography
Purpose To compare structural and vascular parameters in the central and peripheral retina and choroid of eyes diagnosed with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) with or without pan-retinal photocoagulation (PRP) using ultrawide-field wept-source optical coherence tomography angiography (SS-OCTA). Methods All participants underwent SS-OCTA imaging centered on the fovea. Retinal and choroidal thickness, vessel density of the superficial capillary plexus (SCP), deep capillary plexus (DCP), choroidal capillary plexus (CCP), and choroidal Sattler ’s and Haller’s...
Source: Ophthalmic Research - January 27, 2023 Category: Opthalmology Source Type: research

Air Versus Perfluoropropane Gas in Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment: A 3-year Retrospective Study
This study aimed to compare anatomical outcomes of air and perfluoropropane gas (C3F8) tamponade in pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD). Methods: In this retrospective study, data were gathered from 578 patients (578 eyes) with RRD. The follow-up records of all 578 patients that underwent primary vitrectomy for RRD with air or C3F8 were examined and analyzed. Surgical outcomes of the two groups were compared. Results: A total of 342 eyes were treated with air and 236 with C3F8. The mean follow-up period was 37.65 ± 2.33 months. Baseline and preoperative clinical characteris...
Source: Ophthalmic Research - January 23, 2023 Category: Opthalmology Source Type: research

Circular RNA in Retina: a potential biomarker and therapeutic target
Circular RNA (circRNA) is a newly discovered non-coding RNA, which forms a closed ring with more than 200 bases in length. CircRNA is formed by back splicing of precursor RNA, and its expression abundance in body fluid is up to 10 times that of homologous linear transcripts. Recently, novel activities for circRNA in various diseases have emerged, ranging from cancer therapy and neurodegenerative diseases. Here, we reviewed the literature on the biogenesis of circrna and its relationship with retinal diseases in recent years. We first described the mechanism, existing form and main function of circRNA. Next, we also pinpoin...
Source: Ophthalmic Research - January 23, 2023 Category: Opthalmology Source Type: research

Comparative Efficacy of Subthreshold Micropulse Laser Photocoagulation vs. Conventional Laser Photocoagulation for Diabetic Macular Edema: A Meta-analysis
Background Laser photocoagulation is an effective procedure for the treatment of diabetic macular edema (DME). However, the beneficial effects of conventional laser photocoagulation (CLP) are accompanied by the destruction of retinal photoreceptors. Therefore, subthreshold micropulse laser photocoagulation (SMLP) was proposed for DME. Objectives This meta-analysis study was performed to evaluate the efficacy and safety of SMLP compared with CLP for the management of DME. Methods The PubMed, Embase, Web of Science, Cochrane, SinoMed, ClinicalTrials.gov, Wanfang and China National Knowledge Infrastructure (CNKI) databas...
Source: Ophthalmic Research - January 20, 2023 Category: Opthalmology Source Type: research

Comparison of Aurolab Aqueous Drainage Implant with Ahmed Glaucoma Valve for refractory glaucoma: a meta-analysis
Conclusions: The AADI is more effective in both its surgical success rate and reducing IOP and A GM. And the two implants may have comparable incidences of adverse events. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 16, 2023 Category: Opthalmology Source Type: research

Elaborate Evaluation of Farnsworth Dichotomous D-15 Panel Test Can Help Differentiate between Best Vitelliform Macular Dystrophy and Autosomal Recessive Bestrophinopathy
(Source: Ophthalmic Research)
Source: Ophthalmic Research - January 12, 2023 Category: Opthalmology Source Type: research

Elaborate evaluation of Farnsworth Dichotomous D-15 Panel Test can help to differentiate between Best vitelliform macular dystrophy and autosomal recessive bestrophinopathy
Conclusions: Elaborate evaluation of the D-15 Panel Tests might help to establish a differential diagnosis between different bestrophinopathies, as the pattern of the colour vision loss is different between BVMD and ARB. The quantitative parameters of colour vision tests in bestrophinopathies are independent of the visual acuity. (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 12, 2023 Category: Opthalmology Source Type: research

Factors That Can Prolong Ocular Treatment Duration in Age-Related Macular Degeneration
This article reviews the established and novel strategies to prolong drug action, in the vitreal cavity, and thus reduce dosing frequency. Increased ocular residency can be attained by increasing drug size as with large molecules, such as KSI 301; adding polyethylene glycol to pegcetacoplan (APL-2) or avacincaptad pegol to increase molecular size; or binding to other targets that increase molecular size, such as vitreal albumin in the case of BI-X. Faricimab is a bispecific antibody in which the fragment crystallizable portion is engineered to prolong ocular residency and reduce systemic exposure. Conversely, small VEGF bi...
Source: Ophthalmic Research - January 10, 2023 Category: Opthalmology Source Type: research