Analysis of retinal microvasculature features in amblyopic eyes: A meta-analysis
Purpose: This meta-analysis aimed to evaluate retinal vessel density (VD) in amblyopic patients using optical coherence tomography angiography (OCTA). Methods: PubMed, Web of Science, Embase, and Cochrane Library databases were systematically searched for published articles comparing retinal microvasculature characteristics in patients with amblyopia and controls. Continuous variable outcomes were assessed using the mean difference (MD) with a 95% confidence interval. Review Manager Version 5.30 was used for the analysis.
Results: Thirteen qualified articles were pooled in this meta-analysis. Compared with controls, the f...
Source: Ophthalmic Research - August 23, 2022 Category: Opthalmology Source Type: research
Clinical Observation of Macular Vessel Density in Type 2 Diabetics with High Myopia
Introduction: To compare the macular retinal vessel density(VD) of diabetics with high myopia, diabetics without high myopia and healthy controls. Methods: This cross-sectional study recruited type 2 diabetic (T2D) people with no history of ocular treatment in our hospital. Thirty T2D people with high myopia (30 eyes) were included in group A, while 30 T2D people (30 eyes) without myopia were included in group B. Another healthy volunteers (30 eyes) were included in group C. The superficial and deep capillary plexuses VD of macular were measured in all subjects by optical coherence tomography angiography (OCTA). In T2D peo...
Source: Ophthalmic Research - August 22, 2022 Category: Opthalmology Source Type: research
Characteristics of retinal pigment epithelium elevations preceding exudative age-related macular degeneration in Japanese.
Conclusions: There is a non-drusen type of exudative AMD that originates from small RPE elevations as well as SIRE. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 17, 2022 Category: Opthalmology Source Type: research
Status of visual impairment among children with special needs in rural China
Conclusion
VI is common among children at special education schools in rural areas; however, routine screening and effective interventions have not been consistently implemented. Effo rts should be made to address this issue in these already disadvantaged children. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 15, 2022 Category: Opthalmology Source Type: research
Macular toxicity of low-concentration cefuroxime during cataract surgery in vitrectomized eyes
The objective of this study was to determine the toxic effect and clinical characteristics of 1 mg/ml cefuroxime sodium on retinas after phacoemulsification in vitrectomized eyes.
Methods: Cataract patients with vitrectomized eyes were studied retrospectively. Phacoemulsification combined with intraocular lens implantation was performed uneventfully. Best Corrected Visual Acuity （BCVA）, intraocular pressure（IOP）, fundus photography, macular central thickness, and angiography were collected and analyzed. They were studied in patients with macular edema to evaluate macular toxicity.
Results: 92 cases (92 eyes) were ...
Source: Ophthalmic Research - August 15, 2022 Category: Opthalmology Source Type: research
The Efficacy of Atelocollagen to Inhibit Fibrotic Proliferation in Tenon Tissue: in vitro study
Conclusion: Since atelocollagen gel effectively suppresses the proliferation of HTFs in TGFβ1 - ind uced transdifferentiation, it may be a potential therapeutic agent in glaucoma surgery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 11, 2022 Category: Opthalmology Source Type: research
The anterior segment biometrics in high myopia eyes
Conclusion: SC area and TM thickness were significa ntly associated with AST0, while AST0 and SS length were not significantly different between high myopia and control groups. The changes in SC and TM dimensions in high myopia eyes might be caused by factors other than AST0 and SS length. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 4, 2022 Category: Opthalmology Source Type: research
Changes in dimensions and functions of crystalline lens in high myopia using CASIA2 optical coherence tomography
In this study, we aim to evaluate the changes of dimensions and functions of crystalline lens in high myopia and its correlated variables using CASIA2 swept-source optical coherence tomography (SS-OCT).
Methods: One hundred and thirty eligible eyes of myopic patients from 18-40 years old were enrolled and divided into low-to-moderate myopia (LMM) and high myopia (HM) groups according to spherical equivalent (SE). Anterior segment features, including lens thickness (LT), anterior radius of curvatu re (ARC), posterior radius of curvature (PRC), anterior chamber depth (ACD) and lens tilt were obtained by CASIA2. Lens power ...
Source: Ophthalmic Research - August 4, 2022 Category: Opthalmology Source Type: research
Novel advances in the study of IgG4-related disease in the eye and ocular adnexa
Immunoglobin (IgG4)-related disease in the eye and ocular adnexa (IgG4-ROD) is a newly discovered autoimmune disease that histologically exhibits extensive lymphocyte and plasma cell infiltration, occlusive phlebitis and mat or whorled fibrosis. The disease can affect multiple ocular tissues and organs, such as the lacrimal gland, extraocular muscles, orbital fat and trigeminal nerve. The main clinical manifestations are chronic, painless swelling of the orbit or unilateral orbit and proptosis, which may be accompanied by peripheral lymphadenopathy. Usually, visual impairment is not apparent, but in severe cases, it can ca...
Source: Ophthalmic Research - July 15, 2022 Category: Opthalmology Source Type: research
The Link between Anterior Scleral Thickness, Corneal Biomechanical Response, and Ocular Parameters
Conclusions: The relationship between the new biomechanical component and the AST provides the first evidence of the association of AST with the corneal response parameters which should be considered in corneal response interpretation. Tissue thickness varied significantly among meridians supporting the asymmetrical expansion of the ocular globe. The AST was associated with several ocular parameters. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 14, 2022 Category: Opthalmology Source Type: research
The link between anterior scleral thickness, corneal biomechanical response and ocular parameters
Purpose: to assess anterior scleral thickness (AST) across diverse scleral meridians and to evaluate the relationship with corneal biomechanical response and several ocular parameters.
Methods: This prospective non-randomized study comprised 50 eyes of 50 patients (mean age, 29.02 ± 9.48 years). Anterior scleral thickness was measured meridionally at three scleral locations (1, 2, and 3 mm posterior to the scleral spur) using swept-source optical coherence tomography. A multivariate model was created to associate AST with several ocular parameters. Principal component analy sis (PCA) was used to reduce linearly the dimen...
Source: Ophthalmic Research - July 14, 2022 Category: Opthalmology Source Type: research
Association between transcription factor 7-like 2 C/T polymorphism and diabetic retinopathy risk: a meta-analysis
Background: Previous studies have suggested a close association between transcription factor 7-like 2 (TCF7L2) polymorphisms and diabetic retinopathy (DR) susceptibility. However, the published results were inconsistent. This meta-analysis was conducted to review and examine the relationship between TCF7L2 rs7903146 C/T polymorphism and DR risk.
Materials and methods: Online databases were searched and the related studies were identified in this meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power. Moreover, heterogeneity test, sensitivity accum...
Source: Ophthalmic Research - July 8, 2022 Category: Opthalmology Source Type: research
Mechanism of myopic defocus or atropine for myopia control: different or similar ways?
Conclusions: Overlapping differen tially expressed mRNAs of only one-tenth could suggest a different mechanism of myopic defocus and intravitreal injection of atropine controlling myopia. EEF1A2 might play an important role in the choroid during the treatment of myopia. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 7, 2022 Category: Opthalmology Source Type: research
Comparison of Accuracy in Keratometries Measured by Different Camera Devices for Predicting the Intraocular Lens Power in Lens-Dislocated Patients
Conclusions: For most instances, TCRP is the best-recommended source of K value while calculating IOL power for EL patients. However, the total keratometry from IOLMaster preferably fits for long eye patients, who require WK adjustment for Haigis formula. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 4, 2022 Category: Opthalmology Source Type: research
Intravitreal Tissue Plasminogen Activator Injection for the Treatment of Proliferative Vitreoretinopathy in a Rabbit Model
Conclusion: Our results suggest that intravitreally injected tPA may show an inhibitory effect on PVR progression. Further exploration in clinical trials is desired. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 30, 2022 Category: Opthalmology Source Type: research
