Innate immune memory in inflammatory arthritis
Nature Reviews Rheumatology, Published online: 06 September 2023; doi:10.1038/s41584-023-01009-0New evidence demonstrates that myelopoiesis in the bone marrow is a critical event in inflammatory arthritis and is maintained by acquired memory in innate immune cells, which perpetuate inflammation and tissue destruction. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 6, 2023 Category: Rheumatology Authors: Maxime M. Jeljeli Iannis E. Adamopoulos Source Type: research
Metal–polyDNA nanoparticles reset the osteoporotic microenvironment
Nature Reviews Rheumatology, Published online: 06 September 2023; doi:10.1038/s41584-023-01027-yNanoparticles consisting of long DNA molecules in association with Ca2+ and PPi4− ions can modulate the pathological osteoporotic microenvironment and promote bone repair. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 6, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
PRESTO estimates PsA risk for patients with psoriasis
Nature Reviews Rheumatology, Published online: 06 September 2023; doi:10.1038/s41584-023-01026-zA new tool, PRESTO, enables estimation of the 1-year and 5-year risks of the development of psoriatic arthritis in patients with psoriasis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 6, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
CD38hiCD8+ T cells characterize ICI-mediated arthritis
Nature Reviews Rheumatology, Published online: 06 September 2023; doi:10.1038/s41584-023-01025-0Although inflammatory arthritis induced by immune-checkpoint inhibitors clinically resembles that of rheumatoid arthritis or psoriatic arthritis, research shows that it differs in its associated T cell response. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 6, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Inflammation across tissues: can shared cell biology help design smarter trials?
Nature Reviews Rheumatology, Published online: 04 September 2023; doi:10.1038/s41584-023-01007-2Similarities in the pathogenesis and treatment of immune-mediated inflammatory diseases suggest that they can be investigated together in basket trials, to reduce the risk of failure of early-phase drug development and to facilitate the study of rare diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 4, 2023 Category: Rheumatology Authors: Tom Hosack Tom Thomas Rahul Ravindran Hans Holm Uhlig Simon Piers Leigh Travis Christopher Dominic Buckley Source Type: research
SGLT2 inhibitors protect podocytes in lupus nephritis
Nature Reviews Rheumatology, Published online: 04 September 2023; doi:10.1038/s41584-023-01024-1New research provides insights into the mechanisms underlying the renal protective effects of sodium glucose cotransporter 2 inhibitors in lupus nephritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 4, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
Nature Reviews Rheumatology, Published online: 04 September 2023; doi:10.1038/s41584-023-01010-7Extracellular vesicles derived from mesenchymal stromal cells provide the therapeutic benefits of the parental cells with advantages relating to immunogenicity and ease of handling. This Review discusses the therapeutic potential of native and modified extracellular vesicles for the treatment of rheumatic diseases, focusing on osteoarthritis and rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 4, 2023 Category: Rheumatology Authors: Giuliana Minani Bertolino Marie Maumus Christian Jorgensen Dani èle Noël Source Type: research
Fibroblast multiplicity in RA: a synovial state of affairs
Nature Reviews Rheumatology, Published online: 21 August 2023; doi:10.1038/s41584-023-01015-2Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting-edge analyses have now defined at least four distinct states of these cells related to their location in the synovium, epigenetic imprinting and the influence of microenvironment mediators. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 21, 2023 Category: Rheumatology Authors: Camilla R. L. Machado Gary S. Firestein Source Type: research
Reply to: Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading?
Nature Reviews Rheumatology, Published online: 21 August 2023; doi:10.1038/s41584-023-01014-3Reply to: Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 21, 2023 Category: Rheumatology Authors: Janet E. Pope Source Type: research
Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading?
Nature Reviews Rheumatology, Published online: 21 August 2023; doi:10.1038/s41584-023-01013-4Is classifying SSc-ILD drugs as either immunosuppressive or anti-fibrotic misleading? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 21, 2023 Category: Rheumatology Authors: Kristofer Andr éasson Viggo Hamberg Jenny Wig én Gunilla Westergren-Thorsson Source Type: research
Remote monitoring in rheumatology: seeing the right patient at the right time
Nature Reviews Rheumatology, Published online: 07 August 2023; doi:10.1038/s41584-023-01008-1The rise in the use of digital health-care technologies such as electronic patient-reported outcome measures enables a transformation of the traditional care model. In light of the increasing demand for rheumatologists, telehealth could enable more efficient usage of scarce face-to-face appointments. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 7, 2023 Category: Rheumatology Authors: Antoni Chan Johannes Knitza Source Type: research
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond
Nature Reviews Rheumatology, Published online: 04 August 2023; doi:10.1038/s41584-023-01002-7The TNF–TNF receptor signalling network has pleiotropic effects that can both promote and protect against immune-mediated diseases. Modulation of this network through the use of TNF receptor-targeting biologic drugs holds promise for treating various diseases, including TNF inhibitor-refractory diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 4, 2023 Category: Rheumatology Authors: Daniela Siegmund Harald Wajant Source Type: research
Urchin-like nanoparticles for miRNA therapy of OA
Nature Reviews Rheumatology, Published online: 03 August 2023; doi:10.1038/s41584-023-01017-0Researchers have developed ‘urchin-like’ ceria nanoparticles with inherent antioxidant properties that efficiently carry therapeutic microRNA, enabling gene therapy following intra-articular injection in a mouse model of osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 3, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Aminoacyl-tRNA synthetases function as alarmins in RA
Nature Reviews Rheumatology, Published online: 03 August 2023; doi:10.1038/s41584-023-01020-5New research indicates that extracellular aminoacyl-tRNA synthetases contribute to the pathogenesis of rheumatoid arthritis by functioning as alarmins, and could be a novel therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 3, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Non-depleting anti-CD19 B cell inhibition
Nature Reviews Rheumatology, Published online: 03 August 2023; doi:10.1038/s41584-023-01018-zAn antibody that targets CD19 on B cells has shown greater inhibitory efficacy than that of anti-CD20 B cell depletion therapy in animal models of autoimmune diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - August 3, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
