Treg cell-inducing nanoparticles show promise for treating OA
Nature Reviews Rheumatology, Published online: 09 January 2023; doi:10.1038/s41584-023-00906-8Lipid nanoparticles loaded with type II collagen and rapamycin can induce antigen-specific regulatory T cell responses and alleviate disease in a mouse model of osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 9, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
mTORC1 implicated in Still’s disease and MAS
Nature Reviews Rheumatology, Published online: 06 January 2023; doi:10.1038/s41584-023-00908-6New evidence from animal models and human studies suggests that mammalian target of rapamycin has a role in the pathophysiology of Still’s disease and macrophage activation syndrome. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 6, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
MIS-C: myths have been debunked, but mysteries remain
Nature Reviews Rheumatology, Published online: 06 January 2023; doi:10.1038/s41584-022-00896-zAlthough elegant work has detailed the clinical presentation, immune response and disease outcome of multisystem inflammatory syndrome in children, many questions remain. Studies in 2022 have explored the nature of the vascular injury, the role of the SARS-CoV-2 spike protein and the association with the current variants of the virus. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 6, 2023 Category: Rheumatology Authors: Jane C. Burns Source Type: research
New refinements aim to optimize articular cartilage tissue engineering
Nature Reviews Rheumatology, Published online: 05 January 2023; doi:10.1038/s41584-022-00889-ySuccessful, long-term treatment of articular cartilage injuries is important for the prevention of osteoarthritis but remains a major challenge. Three studies in 2022 highlight new approaches to improving articular cartilage regeneration. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 5, 2023 Category: Rheumatology Authors: Nicole Sch äfer Susanne Gr ässel Source Type: research
Ferritin-induced NETs lead to cytokine storm in AOSD
Nature Reviews Rheumatology, Published online: 04 January 2023; doi:10.1038/s41584-022-00899-wNew research reveals that ferritin has an essential role in neutrophil extracellular trap (NET)-mediated inflammation, and suggests that NETs or the ferritin receptor MSR1 could be targeted for the treatment of adult-onset Still disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 4, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Bimekizumab safe and effective for psoriatic arthritis
Nature Reviews Rheumatology, Published online: 03 January 2023; doi:10.1038/s41584-022-00903-3Bimekizumab safe and effective for psoriatic arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Long-term anifrolumab safe in SLE
Nature Reviews Rheumatology, Published online: 03 January 2023; doi:10.1038/s41584-022-00902-4Long-term anifrolumab safe in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Cancer and cardiovascular risk with JAK inhibition
Nature Reviews Rheumatology, Published online: 03 January 2023; doi:10.1038/s41584-022-00901-5Cancer and cardiovascular risk with JAK inhibition (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Phenotypic heterogeneity in psoriatic arthritis: towards tissue pathology-based therapy
Nature Reviews Rheumatology, Published online: 03 January 2023; doi:10.1038/s41584-022-00874-5In this Review, the authors discuss how emerging insights into the tissue-specific pathogenetic mechanisms underlying clinical heterogeneity in psoriatic arthritis support the need for tissue-based precision therapy for the disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 3, 2023 Category: Rheumatology Authors: Aurelie Najm Carl S. Goodyear Iain B. McInnes Stefan Siebert Source Type: research
Busting the myth of methotrexate chronic hepatotoxicity
Nature Reviews Rheumatology, Published online: 23 December 2022; doi:10.1038/s41584-022-00883-4Methotrexate is commonly used in the treatment of inflammatory rheumatic diseases. In this Review, the authors discuss the potential hepatotoxicity of methotrexate, with particular consideration of the role of chronic liver disease, and suggest screening and monitoring strategies for patients receiving methotrexate. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 23, 2022 Category: Rheumatology Authors: Vincent Di Martino Delphine Weil Verhoeven Frank Verhoeven Fran çois Aubin J érome Avouac Lucine Vuitton Fr édéric Lioté Thierry Th évenot Daniel Wendling Source Type: research
‘Hyalinization’ for cartilage regeneration
Nature Reviews Rheumatology, Published online: 22 December 2022; doi:10.1038/s41584-022-00898-xA novel strategy for the repair of articular cartilage involves converting fibrocartilage to hyaline cartilage by modifying the cytoskeleton of fibrotic chondrocytes. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 22, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Vascular Behçet syndrome: from pathogenesis to treatment
Nature Reviews Rheumatology, Published online: 21 December 2022; doi:10.1038/s41584-022-00880-7In this Review, the authors discuss vascular involvement in Behçet syndrome and how the unusual pathogenesis involving an impaired immune-inflammatory response influences the treatment approach, which differs from that of other vasculitides. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 21, 2022 Category: Rheumatology Authors: Alessandra Bettiol Fatma Alibaz-Oner Haner Direskeneli Gulen Hatemi David Saadoun Emire Seyahi Domenico Prisco Giacomo Emmi Source Type: research
Hypoxia-modifying hydrogel supports stem cells for joint repair
Nature Reviews Rheumatology, Published online: 21 December 2022; doi:10.1038/s41584-022-00895-0New research shows that combining a hydrogel with nanozymes to modify the hypoxic, inflammatory joint environment in rheumatoid arthritis enables stem cells to promote osseointegration. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 21, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
Gene-expression profiles predict rituximab response in SLE
Nature Reviews Rheumatology, Published online: 21 December 2022; doi:10.1038/s41584-022-00897-yAn analysis of blood gene-expression signatures in patients with systemic lupus erythematosus has identified several patterns of expression, some of which are associated with disease activity and features such as the response to rituximab. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 21, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
New developments in electronic health record analysis
Nature Reviews Rheumatology, Published online: 19 December 2022; doi:10.1038/s41584-022-00894-1Electronic health records (EHRs) contain enormous amounts of real-world data that could inform researchers, doctors and patients about many aspects of rheumatology. However, EHRs are not yet fully utilized, mainly because automatic data extraction is difficult. Several studies in 2022 highlight the feasibility and clinical utility of computer-assisted EHR analysis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 19, 2022 Category: Rheumatology Authors: Jutta G. Richter Christian Thielscher Source Type: research
