Author Correction: New genes, pathways and therapeutic targets in autoinflammatory diseases
Nature Reviews Rheumatology, Published online: 08 January 2024; doi:10.1038/s41584-024-01075-yAuthor Correction: New genes, pathways and therapeutic targets in autoinflammatory diseases (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 8, 2024 Category: Rheumatology Authors: Riccardo Papa Marco Gattorno Source Type: research
Advances in the treatment of polymyalgia rheumatica and giant cell arteritis
Nature Reviews Rheumatology, Published online: 08 January 2024; doi:10.1038/s41584-023-01069-2Research published in 2023 has demonstrated the efficacy of sarilumab for IL-6 blockade in polymyalgia rheumatica and of secukinumab for IL-17 blockade in giant cell arteritis (GCA). Furthermore, preliminary results with human monocyte-derived suppressive cells suggest the potential of cellular therapeutics for the treatment of GCA. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 8, 2024 Category: Rheumatology Authors: Lindsay Lally Robert Spiera Source Type: research
Exploring the latest advances in axial spondyloarthritis management
Nature Reviews Rheumatology, Published online: 08 January 2024; doi:10.1038/s41584-023-01072-7Studies published in 2023 emphasize the long-term efficacy and safety of novel therapeutics for both radiographic and non-radiographic axial spondyloarthritis (axSpA) and provide a consensus definition of ‘early axSpA’ for use in research studies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 8, 2024 Category: Rheumatology Authors: Diego Benavent Victoria Navarro-Comp án Source Type: research
Large language models: rheumatologists’ newest colleagues?
Nature Reviews Rheumatology, Published online: 04 January 2024; doi:10.1038/s41584-023-01070-9In 2023, large language models demonstrated potential for use in rheumatology to accurately suggest diagnoses and provide empathetic patient education. However, the propensity of this technology to generate misleading information continues to pose risks. Balancing innovation with physician guidance is essential. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 4, 2024 Category: Rheumatology Authors: Vincenzo Venerito Latika Gupta Source Type: research
Epidemiology of Sjögren syndrome
Nature Reviews Rheumatology, Published online: 18 December 2023; doi:10.1038/s41584-023-01057-6In this epidemiological Review, the authors summarize the available evidence relating to the prevalence, incidence, risk factors and mortality associated with the autoimmune disorder Sjögren syndrome, with or without the co-occurrence of other connective tissue diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 18, 2023 Category: Rheumatology Authors: Maxime Beydon Sara McCoy Yann Nguyen Takayuki Sumida Xavier Mariette Rapha èle Seror Source Type: research
Emerging therapeutic options for refractory gout
Nature Reviews Rheumatology, Published online: 15 December 2023; doi:10.1038/s41584-023-01066-5For individuals with gout, the treatment options beyond conventional urate-lowering therapies are expanding. Notable advancements in 2023 include developments in uricase therapy, new xanthine oxidase inhibitors, and a class of medications that offer dual benefits for the control of type 2 diabetes mellitus and gout. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 15, 2023 Category: Rheumatology Authors: Kanon Jatuworapruk Worawit Louthrenoo Source Type: research
New genes, pathways and therapeutic targets in autoinflammatory diseases
Nature Reviews Rheumatology, Published online: 14 December 2023; doi:10.1038/s41584-023-01063-8Studies in 2023 have described eight new monogenic autoinflammatory diseases and their accompanying disease-causing mutations, uncovering clinical phenotypes, pathogenic mechanisms and therapeutic targets. Researchers have identified autoinflammatory pathways linked to mitochondrial dysfunction or overactivation of SRC family kinases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 14, 2023 Category: Rheumatology Authors: Riccardo Papa Marco Gattorno Source Type: research
Biological and clinical roles of IL-18 in inflammatory diseases
Nature Reviews Rheumatology, Published online: 11 December 2023; doi:10.1038/s41584-023-01053-wIn this Review, the authors discuss the role of IL-18 in human inflammatory disease. They describe the mechanisms of IL-18 biology, discuss how dysregulation of this biology leads to immunopathology, and note the biological and clinical circumstances in which therapeutic manipulation might alleviate suffering and save lives. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 11, 2023 Category: Rheumatology Authors: Emily Landy Hallie Carol Aaron Ring Scott Canna Source Type: research
Nanohybrid therapy hits multiple arthritis targets
Nature Reviews Rheumatology, Published online: 07 December 2023; doi:10.1038/s41584-023-01064-7A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmunity in a mouse model of arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 7, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Profiling joint tissues at single-cell resolution: advances and insights
Nature Reviews Rheumatology, Published online: 06 December 2023; doi:10.1038/s41584-023-01052-xIn this Review, Pandey and Bhutani describe the use of single-cell ‘omics’ technologies to identify cell subpopulations in joint tissues in health and disease, thereby contributing to the construction of joint cell atlases and the identification of pathogenetic cell subpopulations that are potential therapeutic targets for diseases such as osteoarthritis and rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 6, 2023 Category: Rheumatology Authors: Akshay Pandey Nidhi Bhutani Source Type: research
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Nature Reviews Rheumatology, Published online: 06 December 2023; doi:10.1038/s41584-023-01054-9In this Review, the authors provide an overview of what is known of the clinical features, pathogenesis and treatment of anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis, including emerging biomarkers and clinical subtypes. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 6, 2023 Category: Rheumatology Authors: Xin Lu Qinglin Peng Guochun Wang Source Type: research
Primary care rheumatology: towards sustainable development in health
Nature Reviews Rheumatology, Published online: 05 December 2023; doi:10.1038/s41584-023-01050-zGlobally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and economic loss worldwide. A shortage of rheumatologists warrants education of primary care doctors in primary care rheumatology, public awareness initiatives and advocacy for rheumatic musculoskeletal health. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 5, 2023 Category: Rheumatology Authors: Debashish Danda Source Type: research
Shifting the SLE management paradigm: challenges and implications
Nature Reviews Rheumatology, Published online: 05 December 2023; doi:10.1038/s41584-023-01058-5Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specifically recommending early and aggressive use of new medications, signal that the old paradigm of SLE management is shifting. Although it presents challenges, this shift is welcome — and is likely to have far-reaching implications. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 5, 2023 Category: Rheumatology Authors: Jacob J. E. Koopman Karen H. Costenbader Source Type: research
Multi-omics reveals distinct MPA subtypes
Nature Reviews Rheumatology, Published online: 01 December 2023; doi:10.1038/s41584-023-01061-wUsing multi-omics analyses, researchers have identified two distinct immunological phenotypes of microscopic polyangiitis, which could inform prognosis and personalized treatment. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - December 1, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Single-cell atlas unveils the diversity of RA synovial tissue
Nature Reviews Rheumatology, Published online: 29 November 2023; doi:10.1038/s41584-023-01059-4Researchers have conducted a comprehensive single-cell analysis of synovial tissue in rheumatoid arthritis, providing insights into the heterogeneity of the disease and informing future treatment strategies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 29, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
