Precision medicine in systemic lupus erythematosus
Nature Reviews Rheumatology, Published online: 11 April 2023; doi:10.1038/s41584-023-00948-yClinical heterogeneity in systemic lupus erythematosus (SLE) is a challenge to effective treatment. This Review describes advances in our understanding of genetic and epigenetic variations in SLE and the roles of immune profiling and biomarker identification in the progress towards precision medicine. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 11, 2023 Category: Rheumatology Authors: Serena Fasano Alessandra Milone Giovanni Francesco Nicoletti David A. Isenberg Francesco Ciccia Source Type: research
Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone
Nature Reviews Rheumatology, Published online: 06 April 2023; doi:10.1038/s41584-023-00935-3Long-term treatment with the anti-resorptive drug denosumab results in a continuous gain in bone mineral density, whereas denosumab withdrawal results in a transient overshoot in bone turnover, with rapid bone loss. This Perspective explores the potential mechanisms underlying these effects. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 6, 2023 Category: Rheumatology Authors: Serge Ferrari Bente Langdahl Source Type: research
Mitochondrial fumarate implicated in inflammation
Nature Reviews Rheumatology, Published online: 06 April 2023; doi:10.1038/s41584-023-00963-zNew findings suggest that inhibition of macrophage fumarate hydratase leads to the release of mitochondrial RNA, which in turn mediates type I interferon production. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 6, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Can ACPA protect against RA?
Nature Reviews Rheumatology, Published online: 05 April 2023; doi:10.1038/s41584-023-00962-0Anti-citrullinated protein antibodies precede the development of rheumatoid arthritis, but new results indicate that these antibodies are not necessarily pathogenic, and some might even protect against arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 5, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Gut T cells help mediate fracture healing
Nature Reviews Rheumatology, Published online: 05 April 2023; doi:10.1038/s41584-023-00961-1Following a fracture, γδ T cell expansion in the bone induces the expansion and migration of T helper 17 cells from the gut to the bone to help mediate fracture healing. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 5, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
How does citrullination contribute to RA autoantibody development?
Nature Reviews Rheumatology, Published online: 04 April 2023; doi:10.1038/s41584-023-00959-9The onset of the destructive autoimmune joint disease rheumatoid arthritis (RA) is preceded by the development of autoantibodies to multiple citrullinated proteins. Research has now shown that citrullination modifies antigen processing, resulting in the production of cryptic epitopes, suggesting a new model for RA autoantibody development. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 4, 2023 Category: Rheumatology Authors: Jean Roudier Isabelle Auger Source Type: research
Allele-specific chromatin looping promotes IRF5-dependent autoimmunity
Nature Reviews Rheumatology, Published online: 03 April 2023; doi:10.1038/s41584-023-00956-yA comprehensive analysis has identified chromatin looping as the mechanism that underlies the association of a pleiotropic genetic variant with several autoimmune diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 3, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
BRAVE news: another one bites the dust
Nature Reviews Rheumatology, Published online: 03 April 2023; doi:10.1038/s41584-023-00957-xThe results of the two BRAVE phase III trials of baricitinib in the treatment of systemic lupus erythematosus were inconclusive, meaning that this clinical trial programme has now been terminated. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Mannosylation is a cause and target in lupus nephritis
Nature Reviews Rheumatology, Published online: 03 April 2023; doi:10.1038/s41584-023-00960-2Autoimmunity-associated recognition by IL-17A-expressing γδ T cells of high-mannose glycans expressed on kidney cells in patients with lupus nephritis can be mitigated in a mouse lupus model by dietary supplementation with N-acetylglucosamine. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 3, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Allele-specific chromatin looping promotes IFR5-dependent autoimmunity
Nature Reviews Rheumatology, Published online: 03 April 2023; doi:10.1038/s41584-023-00956-yA comprehensive analysis has identified chromatin looping as the mechanism that underlies the association of a pleiotropic genetic variant with several autoimmune diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 3, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19
Nature Reviews Rheumatology, Published online: 28 March 2023; doi:10.1038/s41584-023-00944-2In this Review, Cutolo et al. provide an overview of the vitamin D endocrine system and explore the biological and clinical effects of vitamin D3 on innate and adaptive immunity in the context of autoimmune rheumatic diseases and COVID-19. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 28, 2023 Category: Rheumatology Authors: Maurizio Cutolo Vanessa Smith Sabrina Paolino Emanuele Gotelli Source Type: research
The 2022 ACR vaccination guideline: a call-to-action
Nature Reviews Rheumatology, Published online: 27 March 2023; doi:10.1038/s41584-023-00954-0Among the limited quality and quantity of evidence on vaccination use in individuals with rheumatic and musculoskeletal diseases, a new guideline, developed with a rigorous methodology, provides useful support to clinicians and patients in making health-related decisions. Most recommendations are conditional, serving as a call to action for further research. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 27, 2023 Category: Rheumatology Authors: In és Colmegna Michael Libman Source Type: research
Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00952-2Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Ana Margarida Pinto Rinie Geenen Tor D. Wager Winfried H äuser Eva Kosek Jacob N. Ablin Kirstine Amris Jaime Branco Dan Buskila Jo ão Castelhano Miguel Castelo-Branco Leslie J. Crofford Mary-Ann Fitzcharles Marina L ópez-Solà Mariana Lu ís Tiago Reis Source Type: research
Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00951-3Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Daniel J. Clauw Ernest H. S. Choy Vitaly Napadow Anushka Soni Kevin F. Boehnke Bruce Naliboff Afton L. Hassett Anne Arewasikporn Andrew Schrepf Chelsea M. Kaplan David Williams Neil Basu Rachel S. Bergmans Richard E. Harris Steven E. Harte Andrea Chadwick Source Type: research
Biologic choice matters in PsA prevention
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00955-zIn a large cohort of patients with psoriasis, treatment with biologic DMARDs targeting the IL-23 pathway was associated with a reduced risk of developing inflammatory arthritis as compared with anti-TNF treatment. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
