Reversal of inflammatory priming prevents arthritic flares
Nature Reviews Rheumatology, Published online: 30 November 2022; doi:10.1038/s41584-022-00881-6Inhibition of epigenetic processes in synovial fibroblasts can reverse inflammatory priming and prevent flares in experimental models of arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 30, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Targeting the DNA damage response attenuates SLE-associated B cell characteristics
Nature Reviews Rheumatology, Published online: 29 November 2022; doi:10.1038/s41584-022-00882-5Inhibition of the DNA damage response kinase ATR prevents B cells from IFNα-mediated acquisition of a systemic lupus erythematosus immunogenic profile. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 29, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

Pre-RA autoantibodies recognize arthritogenic gut bacterium
Nature Reviews Rheumatology, Published online: 29 November 2022; doi:10.1038/s41584-022-00884-3A gut bacterium found in people at risk of rheumatoid arthritis (RA) or with early RA is recognized by circulating autoantibodies, and is arthritogenic when it colonizes germ-free mice, suggesting a causal role in RA development. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 29, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

Understanding synovial cell diversity in post-traumatic OA
Nature Reviews Rheumatology, Published online: 25 November 2022; doi:10.1038/s41584-022-00876-3Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has taken a back seat to that of the cartilage and chondrocytes. The influence of synoviocytes in OA is increasingly recognized, but are synoviocytes equal in their contributions to disease progression? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 25, 2022 Category: Rheumatology Authors: Jason S. Rockel Mohit Kapoor Source Type: research

Glycobiology of rheumatic diseases
Nature Reviews Rheumatology, Published online: 23 November 2022; doi:10.1038/s41584-022-00867-4Glycosylation is a common modification that can affect protein stability and interactions. In this Review, the authors discuss the role of glycosylation in rheumatic diseases, as well as the therapeutic potential of glycosylation-based interventions. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 23, 2022 Category: Rheumatology Authors: Theresa Kissel Ren é E. M. Toes Thomas W. J. Huizinga Manfred Wuhrer Source Type: research

Can molecular dynamics facilitate the design of protein–protein-interaction inhibitors?
Nature Reviews Rheumatology, Published online: 22 November 2022; doi:10.1038/s41584-022-00877-2The design of effective inhibitors of protein–protein interactions is challenging. In a new study, thermal fluctuation of protein structure was simulated to identify small-molecule candidates that inhibit protein–protein interactions. The application of this technique to other protein–protein interactions might facilitate the replacement of biologic agents with orally available small-molecule drugs. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 22, 2022 Category: Rheumatology Authors: Masashi Honma Hiroshi Suzuki Source Type: research

Mapping the immune landscape of MDA5+ dermatomyositis
Nature Reviews Rheumatology, Published online: 18 November 2022; doi:10.1038/s41584-022-00879-0Using a combination of various single-cell and immune profiling approaches, researchers have characterized the unique adaptive immune landscape of anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) dermatomyositis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 18, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Cutaneous bacteria promote autoimmunity in mice
Nature Reviews Rheumatology, Published online: 18 November 2022; doi:10.1038/s41584-022-00878-1New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 18, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

Hydroxychloroquine dose: balancing toxicity and SLE flare risk
Nature Reviews Rheumatology, Published online: 10 November 2022; doi:10.1038/s41584-022-00868-3Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 10, 2022 Category: Rheumatology Authors: Tiphaine Lenfant Nathalie Costedoat-Chalumeau Source Type: research

Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Nature Reviews Rheumatology, Published online: 09 November 2022; doi:10.1038/s41584-022-00864-7Various types of immune cells are dysregulated in systemic sclerosis and contribute to the initiation and progression of fibrosis. In this Review, the authors summarize various immune cell defects implicated in this disease that are current or potential targets for therapy. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 9, 2022 Category: Rheumatology Authors: Dan Fang Beidi Chen Alain Lescoat Dinesh Khanna Rong Mu Source Type: research

Aberrant regulation of autophagy linked to OA
Nature Reviews Rheumatology, Published online: 04 November 2022; doi:10.1038/s41584-022-00872-7Disruption of a newly identified axis involved in the regulation of autophagy in chondrocytes is implicated in osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 4, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Single-cell-based platform maps response to candidate DMOADs
Nature Reviews Rheumatology, Published online: 04 November 2022; doi:10.1038/s41584-022-00871-8A new study demonstrates that a single-cell mass cytometry approach can provide a precise snapshot of how candidate drugs affect chondrocyte subpopulations from patients with osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 4, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Age-related mechanisms in the context of rheumatic disease
Nature Reviews Rheumatology, Published online: 03 November 2022; doi:10.1038/s41584-022-00863-8In this Review, the authors describe the involvement of characteristic hallmarks of ageing in rheumatic diseases, suggesting that these chronic conditions can be considered to be diseases of premature or accelerated ageing, in which anti-ageing drugs may have therapeutic benefits. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 3, 2022 Category: Rheumatology Authors: Ghada Alsaleh Felix C. Richter Anna K. Simon Source Type: research

In-joint photocatalytic hydrogen production prevents RA in mice
Nature Reviews Rheumatology, Published online: 03 November 2022; doi:10.1038/s41584-022-00870-9Newly developed nanorods that enable photocatalytic intra-articular release of hydrogen prevent the development of collagen-induced arthritis in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 3, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research

CXCL5 effective in mouse model of SLE
Nature Reviews Rheumatology, Published online: 02 November 2022; doi:10.1038/s41584-022-00869-2In a mouse model of lupus, treatment with CXCL5 reduces disease activity and promotes survival. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 2, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research