Cutaneous bacteria promote autoimmunity in mice
Nature Reviews Rheumatology, Published online: 18 November 2022; doi:10.1038/s41584-022-00878-1New research demonstrates that unrestrained cutaneous growth of Staphylococcus aureus causes autoimmunity characteristic of systemic lupus erythematosus in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 18, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
Hydroxychloroquine dose: balancing toxicity and SLE flare risk
Nature Reviews Rheumatology, Published online: 10 November 2022; doi:10.1038/s41584-022-00868-3Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 10, 2022 Category: Rheumatology Authors: Tiphaine Lenfant Nathalie Costedoat-Chalumeau Source Type: research
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Nature Reviews Rheumatology, Published online: 09 November 2022; doi:10.1038/s41584-022-00864-7Various types of immune cells are dysregulated in systemic sclerosis and contribute to the initiation and progression of fibrosis. In this Review, the authors summarize various immune cell defects implicated in this disease that are current or potential targets for therapy. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 9, 2022 Category: Rheumatology Authors: Dan Fang Beidi Chen Alain Lescoat Dinesh Khanna Rong Mu Source Type: research
Aberrant regulation of autophagy linked to OA
Nature Reviews Rheumatology, Published online: 04 November 2022; doi:10.1038/s41584-022-00872-7Disruption of a newly identified axis involved in the regulation of autophagy in chondrocytes is implicated in osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 4, 2022 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Single-cell-based platform maps response to candidate DMOADs
Nature Reviews Rheumatology, Published online: 04 November 2022; doi:10.1038/s41584-022-00871-8A new study demonstrates that a single-cell mass cytometry approach can provide a precise snapshot of how candidate drugs affect chondrocyte subpopulations from patients with osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 4, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Age-related mechanisms in the context of rheumatic disease
Nature Reviews Rheumatology, Published online: 03 November 2022; doi:10.1038/s41584-022-00863-8In this Review, the authors describe the involvement of characteristic hallmarks of ageing in rheumatic diseases, suggesting that these chronic conditions can be considered to be diseases of premature or accelerated ageing, in which anti-ageing drugs may have therapeutic benefits. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 3, 2022 Category: Rheumatology Authors: Ghada Alsaleh Felix C. Richter Anna K. Simon Source Type: research
In-joint photocatalytic hydrogen production prevents RA in mice
Nature Reviews Rheumatology, Published online: 03 November 2022; doi:10.1038/s41584-022-00870-9Newly developed nanorods that enable photocatalytic intra-articular release of hydrogen prevent the development of collagen-induced arthritis in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 3, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
CXCL5 effective in mouse model of SLE
Nature Reviews Rheumatology, Published online: 02 November 2022; doi:10.1038/s41584-022-00869-2In a mouse model of lupus, treatment with CXCL5 reduces disease activity and promotes survival. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - November 2, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
Target neutrophils to treat thrombotic APS?
Nature Reviews Rheumatology, Published online: 29 October 2022; doi:10.1038/s41584-022-00866-5New research suggests therapies targeting neutrophil activation pathways could protect against arterial and venous thrombosis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 29, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research
CAR T cells induce drug-free SLE remission
Nature Reviews Rheumatology, Published online: 24 October 2022; doi:10.1038/s41584-022-00865-6Results from a study of CAR T cell therapy in five patients with treatment-refractory systemic lupus erythematosus demonstrate the induction of sustained drug-free disease remission. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 24, 2022 Category: Rheumatology Authors: Robert Phillips Source Type: research
Precision medicine: the precision gap in rheumatic disease
Nature Reviews Rheumatology, Published online: 10 October 2022; doi:10.1038/s41584-022-00845-wIn this Perspective, with specific reference to rheumatoid arthritis, Lin, Cooles and Isaacs identify factors that have contributed to the relatively slow progress towards precision medicine for rheumatic diseases, and suggest strategies for closing this ‘precision gap’. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 10, 2022 Category: Rheumatology Authors: Chung M. A. Lin Faye A. H. Cooles John D. Isaacs Source Type: research
Author Correction: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021
Nature Reviews Rheumatology, Published online: 10 October 2022; doi:10.1038/s41584-022-00861-wAuthor Correction: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021 (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 10, 2022 Category: Rheumatology Authors: Laura C. Coates Enrique R. Soriano Nadia Corp Heidi Bertheussen Kristina Callis Duffin Cristiano B. Campanholo Jeffrey Chau Lihi Eder Daniel G. Fern ández-Ávila Oliver FitzGerald Amit Garg Dafna D. Gladman Niti Goel Philip S. Helliwell M. Elaine Husni D Source Type: research
ETS1 implicated in polarization of tissue-destructive fibroblasts
Nature Reviews Rheumatology, Published online: 10 October 2022; doi:10.1038/s41584-022-00860-xNew research suggests that the transcription factor ETS1 expressed in fibroblasts regulates the tissue-destructive properties of these cells in multiple diseases, and could offer a novel therapeutic strategy. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 10, 2022 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Publisher Correction: The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET
Nature Reviews Rheumatology, Published online: 06 October 2022; doi:10.1038/s41584-022-00862-9Publisher Correction: The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 6, 2022 Category: Rheumatology Authors: Rosaria Talarico Silvia Aguilera Tobias Alexander Zahir Amoura Ana M. Antunes Laurent Arnaud Tadej Avcin Lorenzo Beretta Stefano Bombardieri Gerd R. Burmester Sara Cannizzo Lorenzo Cavagna Benjamin Chaigne Alain Cornet Nathalie Costedoat-Chalumeau Andrea Source Type: research
Keeping immunostimulatory self-RNA under the rADAR
Nature Reviews Rheumatology, Published online: 06 October 2022; doi:10.1038/s41584-022-00859-4Structural modification of RNA by adenosine-to-inosine editing renders self-RNA invisible to RNA sensors of the innate immune system. Lack of RNA editing unleashes inflammatory responses that can lead to autoinflammation. A deeper understanding of the associated signalling pathways might reveal potential targets for drug discovery for autoinflammatory diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 6, 2022 Category: Rheumatology Authors: Christine Wolf Min Ae Lee-Kirsch Source Type: research
